benphothiamine has been researched along with Diabetic Retinopathy in 6 studies
benfotiamine : A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation.
Diabetic Retinopathy: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We aimed at investigating whether pulsed exposure to different glucose concentrations influences apoptosis in human retinal pericytes (HRP) versus bovine retinal pericytes (BRP), with consequences on the onset of diabetic retinopathy, and the possible protective role of thiamine." | 3.75 | Different apoptotic responses of human and bovine pericytes to fluctuating glucose levels and protective role of thiamine. ( Beltramo, E; Berrone, E; Porta, M; Tarallo, S, 2009) |
| "Hyperglycemia is a causal factor in the development of the vascular complications of diabetes." | 1.33 | Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose. ( Ape, AU; Beltramo, E; Berrone, E; Porta, M; Solimine, C, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beltramo, E | 4 |
| Berrone, E | 4 |
| Tarallo, S | 3 |
| Porta, M | 4 |
| Nizheradze, K | 1 |
| Hammes, HP | 1 |
| Du, X | 1 |
| Edelstein, D | 1 |
| Taguchi, T | 1 |
| Matsumura, T | 1 |
| Ju, Q | 1 |
| Lin, J | 1 |
| Bierhaus, A | 1 |
| Nawroth, P | 1 |
| Hannak, D | 1 |
| Neumaier, M | 1 |
| Bergfeld, R | 1 |
| Giardino, I | 1 |
| Brownlee, M | 1 |
| Solimine, C | 1 |
| Ape, AU | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-Blind Clinical Trial of Benfotiamine Treatment in Diabetic Nephropathy[NCT00565318] | Phase 4 | 86 participants (Anticipated) | Interventional | 2007-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for benphothiamine and Diabetic Retinopathy
| Article | Year |
|---|---|
Different apoptotic responses of human and bovine pericytes to fluctuating glucose levels and protective role of thiamine.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Cattle; Cell Line; Cells, Cultured; Di | 2009 |
Thiamine and benfotiamine prevent apoptosis induced by high glucose-conditioned extracellular matrix in human retinal pericytes.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Adhesion; Cell Proliferation; Cells, Cultured; Cytopr | 2009 |
Human pericyte-endothelial cell interactions in co-culture models mimicking the diabetic retinal microvascular environment.
Topics: Apoptosis; Cell Communication; Cell Proliferation; Cells, Cultured; Coculture Techniques; Diabetic R | 2012 |
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.
Topics: Animals; Cattle; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelium | 2003 |
[Diabetes mellitus. Retinal lesions should not exist!].
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme Activation; Glycated Hemoglob | 2004 |
Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose.
Topics: Aldehyde Reductase; Animals; Cattle; Cell Culture Techniques; Chelating Agents; Diabetic Retinopathy | 2006 |