benphothiamine has been researched along with Diabetes Mellitus, Type 1 in 8 studies
benfotiamine : A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Male participants with and without type 1 diabetes were studied in the General Clinical Research Centre of the Albert Einstein College of Medicine." | 2.73 | Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes. ( Brownlee, M; Du, X; Edelstein, D, 2008) |
| "165 patients with symmetrical, distal diabetic polyneuropathy were randomised to one of three treatment groups entering the wash-out phase and 133/124 patients were analysed in the ITT/PP analysis: Benfotiamine 600 mg per day (n=47/43), benfotiamine 300 mg per day (n=45/42) or placebo (n=41/39)." | 2.73 | Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. ( Achenbach, U; Bretzel, RG; Federlin, K; Gaus, W; Stracke, H, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Du, X | 1 |
| Edelstein, D | 1 |
| Brownlee, M | 1 |
| Fraser, DA | 1 |
| Diep, LM | 1 |
| Hovden, IA | 1 |
| Nilsen, KB | 1 |
| Sveen, KA | 1 |
| Seljeflot, I | 1 |
| Hanssen, KF | 1 |
| Katare, R | 1 |
| Oikawa, A | 1 |
| Cesselli, D | 1 |
| Beltrami, AP | 1 |
| Avolio, E | 1 |
| Muthukrishnan, D | 1 |
| Munasinghe, PE | 1 |
| Angelini, G | 1 |
| Emanueli, C | 1 |
| Madeddu, P | 1 |
| Engelen, L | 1 |
| Stehouwer, CD | 1 |
| Schalkwijk, CG | 1 |
| Haupt, E | 1 |
| Ledermann, H | 1 |
| Köpcke, W | 1 |
| Jermendy, G | 1 |
| Stracke, H | 1 |
| Gaus, W | 1 |
| Achenbach, U | 1 |
| Federlin, K | 1 |
| Bretzel, RG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of the Glucosamine Pathway and Reactive Oxygen Species in the Pathogenesis of Diabetic Complications[NCT00703989] | 21 participants (Actual) | Interventional | 2005-02-28 | Completed | |||
| Can Oral Benfotiamine Supplementation Influence Progression of Microvascular Complications in Patients With Type 1 Diabetes?[NCT00117026] | Phase 1/Phase 2 | 67 participants (Actual) | Interventional | 2005-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for benphothiamine and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Current therapeutic interventions in the glycation pathway: evidence from clinical studies.
Topics: Animals; Atherosclerosis; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathie | 2013 |
4 trials available for benphothiamine and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes.
Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Cytochrome P-450 Enzyme System; Diabe | 2008 |
The effects of long-term oral benfotiamine supplementation on peripheral nerve function and inflammatory markers in patients with type 1 diabetes: a 24-month, double-blind, randomized, placebo-controlled trial.
Topics: Adolescent; Adult; Biomarkers; Diabetes Mellitus, Type 1; Double-Blind Method; Drug Administration S | 2012 |
Benfotiamine in the treatment of diabetic polyneuropathy--a three-week randomized, controlled pilot study (BEDIP study).
Topics: Adjuvants, Immunologic; Adolescent; Adult; Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type | 2005 |
Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study.
Topics: Adjuvants, Immunologic; Adult; Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic | 2008 |
3 other studies available for benphothiamine and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes.
Topics: Animals; Antigens, CD; Antigens, Ly; Apoptosis; Biomarkers; Blood Glucose; Cell Proliferation; Cell | 2013 |
[Oral benfotiamine therapy. Thus you protect the nerves of diabetic patients].
Topics: Administration, Oral; Controlled Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Melli | 2004 |
Evaluating thiamine deficiency in patients with diabetes.
Topics: Case-Control Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Male; Mi | 2006 |