benphothiamine has been researched along with Depression in 2 studies
benfotiamine : A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Severe alcoholism can be associated with significant nutritional and vitamin deficiency, especially vitamin B1 (thiamine) which is associated with neurological deficits impacting mood and cognition." | 5.20 | Change in psychiatric symptomatology after benfotiamine treatment in males is related to lifetime alcoholism severity. ( Butler, MG; Manzardo, AM; Pendleton, T; Penick, EC; Poje, A, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gorlova, A | 1 |
| Pavlov, D | 1 |
| Anthony, DC | 1 |
| Ponomarev, ED | 1 |
| Sambon, M | 1 |
| Proshin, A | 1 |
| Shafarevich, I | 1 |
| Babaevskaya, D | 1 |
| Lesсh, KP | 1 |
| Bettendorff, L | 1 |
| Strekalova, T | 1 |
| Manzardo, AM | 1 |
| Pendleton, T | 1 |
| Poje, A | 1 |
| Penick, EC | 1 |
| Butler, MG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effectiveness of Benfotiamine in Reducing Abusive Drinking Among Family History Positive and Negative Alcoholics[NCT00680121] | Phase 4 | 120 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The alcoholism severity scale measures the severity of a person's dependence to alcohol. The scale ranges from a score of 0 (least severe) to 33 (most severe). The higher the score the worse the dependence. (NCT00680121)
Timeframe: 6 Months
| Intervention | scores on a scale (Mean) |
|---|---|
| Control Group | 14.0 |
| Benfotiamine | 10.7 |
Scale measures impulsiveness. It includes 30 items that are scored to yield six first-order factors (attention, motor, self-control, cognitive complexity, perseverance, and cognitive instability impulsiveness) and three second-order factors (attentional, motor, and non-planning impulsiveness). Items are scored on a 4 point scale with 1 point equaling rarely/never up to 4 points equaling almost always/always. Total impulsivity score ranges from 30 (least impulsive) to 120 (most impulsive). The higher the score the higher the level of impulsiveness. (NCT00680121)
Timeframe: 6 Months
| Intervention | scores on a scale (Mean) |
|---|---|
| Control Group | 65.0 |
| Benfotiamine | 65.4 |
measured as standard drinks of alcohol per day (SD/day) (NCT00680121)
Timeframe: Change from Baseline to 6 Months
| Intervention | alcoholic drinks per day (Mean) |
|---|---|
| Control Group | -3.4 |
| Benfotiamine | -3.0 |
The SCL-90 is a brief multidimensional self-report inventory that screens for nine symptoms of psychopathology and provides three global distress indicators. It provides an overview of symptom severity and intensity. The outcome measures psychiatric symptoms using a 30-item scale reported as t-scores relative to a normative population. (NCT00680121)
Timeframe: 6 Months
| Intervention | t-score (Mean) |
|---|---|
| Control Group | 1.02 |
| Benfotiamine | 1.04 |
1 trial available for benphothiamine and Depression
| Article | Year |
|---|---|
Change in psychiatric symptomatology after benfotiamine treatment in males is related to lifetime alcoholism severity.
Topics: Adult; Alcoholism; Depression; Double-Blind Method; Humans; Male; Middle Aged; Psychiatric Status Ra | 2015 |
1 other study available for benphothiamine and Depression
| Article | Year |
|---|---|
Thiamine and benfotiamine counteract ultrasound-induced aggression, normalize AMPA receptor expression and plasticity markers, and reduce oxidative stress in mice.
Topics: Aggression; Animals; Antioxidants; Brain; Depression; Male; Mice, Inbred BALB C; Neuronal Plasticity | 2019 |