benphothiamine has been researched along with Cognitive Dysfunction in 1 studies
benfotiamine : A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation.
Cognitive Dysfunction: Diminished or impaired mental and/or intellectual function.
Excerpt | Relevance | Reference |
---|---|---|
"The primary clinical outcome was the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog)." | 2.94 | Benfotiamine and Cognitive Decline in Alzheimer's Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial. ( Bettendorff, L; Chen, H; Chen, Z; Cirio, R; Flowers, SA; Fonzetti, P; Franchino-Elder, J; Gerber, LM; Gibson, GE; Grandville, T; Habeck, C; Hirsch, JA; Jordan, B; Luchsinger, JA; Schupf, N; Stern, Y; Xu, H, 2020) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 1 (100.00) | 2.80 |
Authors | Studies |
---|---|
Gibson, GE | 1 |
Luchsinger, JA | 1 |
Cirio, R | 1 |
Chen, H | 1 |
Franchino-Elder, J | 1 |
Hirsch, JA | 1 |
Bettendorff, L | 1 |
Chen, Z | 1 |
Flowers, SA | 1 |
Gerber, LM | 1 |
Grandville, T | 1 |
Schupf, N | 1 |
Xu, H | 1 |
Stern, Y | 1 |
Habeck, C | 1 |
Jordan, B | 1 |
Fonzetti, P | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Benfotiamine in Alzheimer's Disease: A Pilot Study[NCT02292238] | Phase 2 | 71 participants (Actual) | Interventional | 2015-02-15 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"The Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) is a brief neuropsychological assessment used to assess the severity of cognitive symptoms of dementia. It is one of the most widely used cognitive scales in clinical trials and is considered to be the gold standard for assessing antidementia treatments. The ADAS-Cog range from 0 to 70, where higher scores indicate greater cognitive dysfunction." (NCT02292238)
Timeframe: Baseline, 1 year
Intervention | score on a scale (Mean) |
---|---|
Benfotiamine | 1.39 |
Placebo | 3.26 |
Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) is a caregiver-based Activities of Daily Living (ADL) scale composed of 23 items developed for use in dementia clinical studies. It was designed to assess the patient's performance of both basic and instrumental activities of daily living such as those necessary for personal care, communicating and interacting with other people, maintaining a household, conducting hobbies and interests, as well as making judgments and decisions. The range for the total ADCS-ADL score is 0 to 78. Higher scores equate with higher functioning. (NCT02292238)
Timeframe: Baseline, 1 year
Intervention | score on a scale (Mean) |
---|---|
Benfotiamine | -1.931 |
Placebo | -3.16129 |
The AAL (Automatic Anatomical Labeling) atlas provides the taxonomy for 116 regions of interest, 90 of which capture non-cerebellar cortical regions. Signal averages from 9 cerebellar regions from each hemisphere were further averaged into one composite cerebellar region for each hemisphere, 'Cerebellum_L' and 'Cerebellum_R', which were comprised of the respective laterality averages of the regions: 'Cerebellum_Crus1 ' 'Cerebellum_Crus2 'Cerebellum_3' 'Cerebellum_4_5' 'Cerebellum_6' 'Cerebellum_7b' 'Cerebellum_8' 'Cerebellum_9' 'Cerebellum_10 '. Subsequently, these two composite regions are further combined with the bilateral paracentral lobules to provide one final composite for reference scaling. Concretely, the values from 'Cerebellum_L', 'Cerebellum_R', 'Paracentral_Lobule_L', and 'Paracentra_Lobule_R' were averaged. This final composite will serve as the denominator for the scaling operation of any ROI value prior to group-level analysis. (NCT02292238)
Timeframe: Baseline, 1 year
Intervention | ratio (Mean) |
---|---|
Benfotiamine | -0.02 |
Placebo | -0.01 |
The SRT is a standard diagnostic tool in the assessment of verbal memory. The Buschke SRT immediate total scores are compared between treated (benfotiamine) and control (placebo) groups. The immediate total score is the sum of correct responses over the 6 learning trials with scores ranging from 0 to 72. A score of 0 means severe impairment in memory. A score of 72 means there is no impairment in memory. For the purpose of determining effect over several trials between groups, the fractional change from the baseline of each group is compared. (NCT02292238)
Timeframe: Baseline, 1 year
Intervention | score on a scale (Mean) |
---|---|
Benfotiamine | 0.86 |
Placebo | -1.12 |
The CDR was developed primarily for use in persons with dementia of the Alzheimer type (the equivalent of probable Alzheimer's Disease) and can also be used to stage dementia in other illnesses as well. The scores for the multiple items are summarized in one score. The CDR examines 6 categories of cognitive functioning domains. Each domain is scored on a scale ranging from 0 to 3 (including 0.5). A CDR-SB was generated as the sum of the values in each of the 6 domains. The CDR-SB sum scores range from 0 to 18, with higher scores indicating greater cognitive impairment and a 1 point worsening is considered a clinically significant symptom change. (NCT02292238)
Timeframe: Baseline, 1 year
Intervention | score on a scale (Mean) |
---|---|
Benfotiamine | 0.05 |
Placebo | 0.22 |
The NPI assesses a wide range of behaviors encountered in dementia patients to provide a means of distinguishing frequency and severity of behavioral changes. Ten behavioral and two neuro-vegetative domains are evaluated through an interview with the caregiver. The total score ranges from 0 to 144. Higher scores suggest greater psychiatric impairment. (NCT02292238)
Timeframe: Baseline, 1 year
Intervention | score on a scale (Mean) |
---|---|
Benfotiamine | 6.69 |
Placebo | 9.23 |
1 trial available for benphothiamine and Cognitive Dysfunction
Article | Year |
---|---|
Benfotiamine and Cognitive Decline in Alzheimer's Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Apolipoprotein E4; Brain; Cognitive D | 2020 |