benoxinate has been researched along with Pain, Postoperative in 11 studies
benoxinate: RN given refers to parent cpd; structure
oxybuprocaine : A benzoate ester in which 4-amino-3-butoxybenzoic acid and 2-(diethylamino)ethanol have combined to form the ester bond; an ester-based local anaesthetic (ester "caine") used especially in ophthalmology and otolaryngology.
Pain, Postoperative: Pain during the period after surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The preoperative and postoperative pain scores were compared using nonparametric tests." | 3.11 | Efficacy and Safety of Oxybuprocaine Hydrochloride Gel in Alleviating Pain during Male Urethral Catheterization: A Single-Center Randomized Controlled Study. ( Chen, H; Chen, X; Cui, Y; Dong, Y; Dong, Z; Qu, X; Zhang, L, 2022) |
| "Bupivacaine drops were effective in providing deep topical anesthesia." | 2.71 | Comparative clinical trial of topical anesthetic agents in cataract surgery: lidocaine 2% gel, bupivacaine 0.5% drops, and benoxinate 0.4% drops. ( Macky, TA; Samir, MK; Soliman, MM, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Dong, Z | 1 |
| Qu, X | 1 |
| Zhang, L | 1 |
| Chen, X | 1 |
| Dong, Y | 1 |
| Chen, H | 1 |
| Cui, Y | 1 |
| Yan, C | 1 |
| Liu, Z | 1 |
| Chen, B | 1 |
| Malek, I | 1 |
| Romdhane, O | 1 |
| Sayadi, J | 1 |
| Mekni, M | 1 |
| Fekih, O | 1 |
| Zghal, I | 1 |
| Nacef, L | 1 |
| Muqit, MM | 1 |
| Marcellino, GR | 1 |
| Gray, JC | 1 |
| McLauchlan, R | 1 |
| Henson, DB | 1 |
| Young, LB | 1 |
| Patton, N | 1 |
| Charles, SJ | 1 |
| Turner, GS | 1 |
| Stanga, PE | 1 |
| Mahfouz, AK | 1 |
| Nabawi, KS | 1 |
| Sauder, G | 1 |
| Jonas, JB | 1 |
| Soliman, MM | 1 |
| Macky, TA | 1 |
| Samir, MK | 1 |
| Benatar-Haserfaty, J | 1 |
| Monleón de la Calle, MP | 1 |
| Sanz-López, A | 1 |
| Muriel García, A | 1 |
| Rao, SK | 1 |
| Wong, VW | 1 |
| Cheng, AC | 1 |
| Lam, PT | 1 |
| Lam, DS | 1 |
| Anders, N | 2 |
| Heuermann, T | 2 |
| Rüther, K | 1 |
| Hartmann, C | 2 |
| Rieck, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Observational Prospective Study of Comparing Pain Responses With Pattern Laser Platform and Conventional Laser System During the Panretinal Photocoagulation in Proliferative Diabetic Retinopathy[NCT02645383] | 30 participants (Actual) | Interventional | 2014-05-31 | Completed | |||
| Clinical Comparison of Two Anesthetic Preparations for Intravitreal Injection[NCT01087489] | 53 participants (Actual) | Interventional | 2010-04-30 | Completed | |||
| Comparison Between 2% Lidocaine Gel and 5% Tetracaine Eye Drop as Topical Anesthesia in Phacoemulsification[NCT03143452] | 72 participants (Actual) | Interventional | 2016-12-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Discomfort according to the Eye Sensation Scale: 1-none, 2- mild, 3- moderate, 4- severe, 5- extremely severe~Patient satisfaction scale: 1=very unsatisfied, 2=unsatisfied, 3=neutral, 4=satisfied, 5= extremely satisfied" (NCT01087489)
Timeframe: immediately after injection, 1- hour later, and next day
| Intervention | units on a scale (Mean) | |||||
|---|---|---|---|---|---|---|
| Discomfort during anesthetic preparation | Discomfort during needle penetration | Satisfaction with entire prep and injection | Discomfort 1 h after injection | Discomfort day after injection | Next day satisfaction with injection | |
| 3.5% Ophthalmic Lidocaine Gel | 2.09 | 2.0 | 4.5 | 2.1 | 1.6 | 4.3 |
| 4% Liquid Lidocaine Method | 2.1 | 1.7 | 4.3 | 2.4 | 1.8 | 4.3 |
intraocular pressure (IOP) was measured immediately after the injection, and at 5, 10, and 15 minutes after the injection (until it was 30 mmHg or below). Prior to injection IOP and post-injection IOP were compared to find the IOP change after injection. (NCT01087489)
Timeframe: immediately after injection, at 5, 10, 15 minutes
| Intervention | mmHg (Mean) | |
|---|---|---|
| baseline IOP before injection | IOP change after 0.05 cc injection | |
| 3.5% Ophthalmic Lidocaine Gel | 15.9 | 30.9 |
| 4% Liquid Lidocaine Method | 15.5 | 25.7 |
"Presence of corneal staining after the injection:~Quadrants of fluorescein staining: 0 1 2 3 4~Density of staining: 0- None 1- Mild 2- Moderate 3- Severe 4- corneal abrasion~Size of subconjunctival hemorrhage:~in clock hours" (NCT01087489)
Timeframe: within 10 minutes of the injection
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Corneal fluorescein staining | Density of corneal staining | |
| 3.5% Ophthalmic Lidocaine Gel | 2.3 | 1.3 |
| 4% Liquid Lidocaine Method | 3.0 | 1.9 |
1 review available for benoxinate and Pain, Postoperative
| Article | Year |
|---|---|
Pain responses of Pascal 20 ms multi-spot and 100 ms single-spot panretinal photocoagulation: Manchester Pascal Study, MAPASS report 2.
Topics: Administration, Topical; Anesthetics, Local; Diabetic Retinopathy; Female; Humans; Light Coagulation | 2010 |
8 trials available for benoxinate and Pain, Postoperative
| Article | Year |
|---|---|
Efficacy and Safety of Oxybuprocaine Hydrochloride Gel in Alleviating Pain during Male Urethral Catheterization: A Single-Center Randomized Controlled Study.
Topics: Adult; Anesthetics, Local; Humans; Lubricants; Male; Mineral Oil; Pain Measurement; Pain, Postoperat | 2022 |
[Cataract surgery with topical anesthesia in adults under 30 years of age: Preliminary study].
Topics: Administration, Topical; Adult; Anesthesia, Local; Cataract Extraction; Female; Humans; Male; Pain M | 2016 |
Pain responses of Pascal 20 ms multi-spot and 100 ms single-spot panretinal photocoagulation: Manchester Pascal Study, MAPASS report 2.
Topics: Administration, Topical; Anesthetics, Local; Diabetic Retinopathy; Female; Humans; Light Coagulation | 2010 |
Preemptive analgesia in rhegmatogenous retinal detachment surgery: is it effective?
Topics: Adolescent; Adult; Analgesia; Anesthesia, General; Anesthesia, Local; Anesthetics, Inhalation; Anest | 2002 |
Topical versus peribulbar anaesthesia for cataract surgery.
Topics: Administration, Topical; Aged; Anesthesia, Local; Anesthetics, Local; Capsulorhexis; Female; Humans; | 2003 |
Comparative clinical trial of topical anesthetic agents in cataract surgery: lidocaine 2% gel, bupivacaine 0.5% drops, and benoxinate 0.4% drops.
Topics: Aged; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Capsulorhexis; Female; Gels; Humans; Lidoc | 2004 |
Comparative clinical trial of topical anesthetic agents in cataract surgery: lidocaine 2% gel, bupivacaine 0.5% drops, and benoxinate 0.4% drops.
Topics: Aged; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Capsulorhexis; Female; Gels; Humans; Lidoc | 2004 |
Comparative clinical trial of topical anesthetic agents in cataract surgery: lidocaine 2% gel, bupivacaine 0.5% drops, and benoxinate 0.4% drops.
Topics: Aged; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Capsulorhexis; Female; Gels; Humans; Lidoc | 2004 |
Comparative clinical trial of topical anesthetic agents in cataract surgery: lidocaine 2% gel, bupivacaine 0.5% drops, and benoxinate 0.4% drops.
Topics: Aged; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Capsulorhexis; Female; Gels; Humans; Lidoc | 2004 |
Clinical and electrophysiologic results after intracameral lidocaine 1% anesthesia: a prospective randomized study.
Topics: Aged; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Electroretinography; Humans; Len | 1999 |
[Peribulbar anesthesia versus topical anesthesia in cataract surgery: comparison of the postoperative course].
Topics: Anesthesia, Local; Anesthetics, Local; Cataract Extraction; Humans; Lidocaine; Pain, Postoperative; | 2000 |
3 other studies available for benoxinate and Pain, Postoperative
| Article | Year |
|---|---|
Comparison of oxybuprocaine and lidocaine topical anesthesia for pain control in radiofrequency ablation treatment of great saphenous vein insufficiency.
Topics: Anesthesia, Local; Humans; Lidocaine; Pain, Postoperative; Radiofrequency Ablation; Saphenous Vein | 2023 |
[Outpatient external dacryocystorhinostomy under regional anesthesia and sedation].
Topics: Aged; Ambulatory Surgical Procedures; Analgesia; Blood Loss, Surgical; Bupivacaine; Dacryocystorhino | 2007 |
Topical anesthesia-induced keratopathy after laser-assisted subepithelial keratectomy.
Topics: Adult; Anesthesia, Local; Anesthetics, Local; Corneal Diseases; Female; Humans; Keratectomy, Subepit | 2007 |