benidipine has been researched along with Hypertension in 81 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (17.28) | 18.2507 |
| 2000's | 39 (48.15) | 29.6817 |
| 2010's | 25 (30.86) | 24.3611 |
| 2020's | 3 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Furui, M; Inagaki, K; Kamei, H; Matsubara, T | 1 |
| Hayashi, K; Makino, H; Matsuzaki, M; Ogihara, T; Ohashi, Y; Rakugi, H; Saruta, T; Shimada, K; Umemoto, S | 1 |
| Abdelsattar, AT; Alamodi, AA; Masoud, AT; Mohammed, OM; Nso, N; Payton, M; Shareef, MA; Sofy, AA | 1 |
| Kario, K; Kawana, M; Matsuzaki, M; Ogihara, T; Ohashi, Y; Rakugi, H; Saruta, T; Shimada, K; Umemoto, S | 1 |
| Chien, CM; Nguyen, PTT; Ryu, JY; Shin, JG; Shon, J; Sunwoo, YE | 1 |
| Baek, SH; Chae, SC; Cho, MC; Choi, DJ; Ha, JW; Ihm, SH; Jeon, HK; Kim, DS; Kim, KH; Kim, KS; Lim, DS | 1 |
| Higaki, J; Ito, S; Kamiya, A; Matsuoka, H; Matsuzaki, M; Ogihara, T; Ohashi, Y; Rakugi, H; Saruta, T; Shimada, K; Shimamoto, K; Suzuki, H; Umemoto, S | 2 |
| Tomino, Y | 1 |
| Higaki, J; Ito, S; Kitagawa, K; Matsumoto, M; Matsuzaki, M; Ogihara, T; Ohashi, Y; Rakugi, H; Saruta, T; Shimada, K; Suzuki, H; Umemoto, S | 1 |
| Ando, K; Fujita, T; Isshiki, M; Kashihara, N; Nakanishi, T; Nangaku, M; Nishizawa, Y; Nitta, K; Rakugi, H; Shimosawa, T; Takahashi, K; Tomita, K; Yokoyama, H | 1 |
| Hirayama, A; Nagao, K; Takahashi, A; Tani, S | 1 |
| Matsuzaki, M; Ogihara, T; Ohashi, Y; Rakugi, H; Saruta, T; Umemoto, S | 2 |
| Hirayama, A; Kanai, T; Kasamaki, Y; Kunimoto, S; Takayama, T; Yajima, Y; Yoda, S | 1 |
| Dai, B; Lv, J; Mei, C; Wang, Y; Xue, C; Yang, B; Yu, S; Zhao, G; Zhou, C | 1 |
| Matsumoto, C; Shiina, K; Tomiyama, H; Yamada, J; Yamashina, A; Yoshida, M | 1 |
| Chen, XC; Fang, NY; Pan, ZH; Wang, CF; Wang, HY; Wu, H; Zhang, H; Zhang, SH; Zhong, Y | 1 |
| Abe, M; Maruyama, N; Maruyama, T; Matsumoto, K; Okada, K | 1 |
| Hoshino, C; Kikuchi, A; Kuriyama, C; Ohta, M; Sato, N; Sugawara, S | 1 |
| Hu, Z; Jiang, B; Li, X; Peng, T; Xia, Q; Yang, X | 1 |
| Dohi, Y; Kimura, G; Miyagawa, K; Nakazawa, A; Sato, K; Sugiura, T; Yamashita, S | 1 |
| Dong, YF; Fukuda, M; Kataoka, K; Kim-Mitsuyama, S; Nakamura, T; Nako, H; Ogawa, H; Yamamoto, E | 1 |
| Futenma, A; Imai, H; Kimura, Y; Maeda, K; Miura, N; Suga, N; Yamada, H | 1 |
| Guo, L; Hu, Z; Jiang, B; Li, XH; Pei, F; Peng, T; Song, J; Xia, Q; Yang, XD | 1 |
| Cheng, XW; Hirashiki, A; Izawa, H; Jin, Z; Kuzuya, M; Murohara, T; Nagata, K; Nishizawa, T; Noda, A; Obata, K; Okumura, K; Sasaki, T; Shi, GP; Takeshita, K | 1 |
| Abe, M; Fujita, T; Maruyama, N; Maruyama, T; Matsumoto, K; Matsumoto, S; Okada, K; Soma, M | 2 |
| Kageyama, S; Saito, I; Saruta, T; Suzuki, H | 2 |
| Fan, W; Qi, W | 1 |
| Abe, K; Eto, T; Higaki, J; Ito, S; Kamiya, A; Kikuchi, K; Matsuoka, H; Matsuzaki, M; Ogihara, T; Ohashi, Y; Rakugi, H; Saruta, T; Shimada, K; Suzuki, H; Suzuki, N; Tei, C; Umemoto, S | 1 |
| Teo, KK | 1 |
| Iwao, H; Kim, S; Nakao, T; Namba, M; Zhan, Y | 1 |
| Iga, A; Ito, S; Kageyama, N; Katoh, K; Kawano, T; Kusunoki, K; Nakaya, Y; Nakayama, T; Nishikado, A; Nomura, M; Okamoto, H; Saito, K; Sawa, Y; Uemura, E | 1 |
| Date, H; Eto, T; Imamura, T; Ishikawa, T; Kita, T; Matsuo, T; Matsuura, Y; Matsuyama, A; Nagoshi, T | 1 |
| Ina, Y; Ohno, T; Sato, H; Sonoda, R; Suzuki, K; Yao, K | 1 |
| Dohi, Y; Kojima, M; Sato, K; Taniguchi, M; Ueda, R | 1 |
| Hibino, T; Kato, K; Matsubara, T; Suzuki, O; Tani, S; Yokoi, K; Yoneyama, A; Yoshida, T | 1 |
| Inoue, S; Tomino, Y | 1 |
| Chen, MZ; Guo, JX; Jin, WY; Li, HY; Sun, W; Zhang, YZ | 1 |
| Iwasaka, T; Nishikawa, M; Nomura, S; Omoto, S; Shouzu, A | 1 |
| Maeda, K; Nakamura, M; Watanabe, T; Yasunari, K; Yoshikawa, J | 1 |
| Aoki, M; Hashiya, N; Makino, H; Miwa, K; Morishita, R; Ogihara, T; Shimizu, H; Yamasaki, K | 1 |
| Baba, T; Hashimoto, S; Katoh, T; Midorikawa, S; Sanada, H; Watanabe, T; Yatabe, J; Yatabe, MS | 1 |
| Miki, H; Nagashima, K; Yao, K | 1 |
| Eto, T; Kita, T; Kitamura, K; Suzuki, Y | 1 |
| Kanai, S; Miyashita, Y; Oyama, T; Sasaki, H; Shirai, K; Yamamura, S | 1 |
| Kamiya, A; Matsuzaki, M; Ogihara, T; Umemoto, S | 1 |
| Hayashi, K; Iigaya, K; Kumagai, H; Onami, T; Takimoto, C | 1 |
| Ikeda, J; Matsubara, M; Yao, K | 1 |
| Fujita, H; Harasawa, S; Ichiyama, I; Kanmatsuse, K; Kushiro, T; Oiwa, K; Otsuka, Y; Saito, F; Takahashi, A; Takahashi, N; Uchiyama, T | 1 |
| Hioki, C; Kawada, T; Kotani, K; Sakane, N; Yoshida, T | 1 |
| Miyaguchi, S; Ota, S; Seino, H; Suzuki, S; Yabe, R; Yamazaki, T | 1 |
| Hayashi, N; Ito, N; Katsuya, T; Ogihara, T; Ohishi, M; Rakugi, H; Shiota, A; Takagi, T; Tatara, Y; Terai, M | 1 |
| Akizuki, O; Ikeda, J; Matsubara, M; Saeki, K; Sasaki, K; Yao, K | 1 |
| Tsuda, K | 1 |
| Karasawa, A; Kusaka, H; Nomura, H | 1 |
| Hara, K; Ito, S; Kanmasse, K; Kawamura, H; Komatsu, K; Maki, M; Mitsubayashi, H; Suzuki, K; Tsukamoto, K; Usui, W | 1 |
| Dohi, Y; Kojima, M; Sato, K | 1 |
| Hara, T; Karasawa, A; Nito, M; Ohta, Y; Sato, H; Yamada, K | 1 |
| Shimamoto, H; Shimamoto, Y | 2 |
| Fukui, M; Shou, I; Takahashi, Y; Tomino, Y; Wang, LN | 1 |
| Kobayashi, H; Kobayashi, S | 1 |
| Hiwada, K; Kohara, K; Muneta, S | 1 |
| Inoue, H; Kagitani, S; Kinuno, H; Takata, M; Tomita, S; Tomoda, F; Yasumoto, K | 1 |
| Karasawa, A; Kobayashi, S; Kosaka, N; Nito, M; Nomura, H; Sonoda, R; Tanaka, H; Yamaguchi, K | 1 |
| Harano, Y; Hasegawa, M; Kanazawa, A; Suzuki, M | 1 |
| Hoshide, S; Ikeda, U; Kario, K; Mitsuhashi, T; Shimada, K | 1 |
| Imai, K; Ina, Y; Kobayashi, S; Nagashima, K; Ohmori, K; Santa, T; Takezawa, K; Tsunoda, M | 1 |
| Dohi, Y; Nakazawa, A; Sato, K; Sugiyama, M; Takase, H; Ueda, R | 1 |
| Akioka, H; Miyazaki, M; Nakajima, O | 1 |
| Bagati, A; Gala, D; Kalke, S; Nair, KG; Shah, BV; Sood, OP | 1 |
| Akashi, T; Harada, M; Hosoya, T; Ikeda, K; Nakagawa, O; Nakao, K; Tojo, K; Tokudome, G | 1 |
| Kakinoki, S; Kitabatake, A; Nomura, A; Takechi, S | 1 |
| Kobayashi, N; Kobayashi, T; Matsuoka, H; Mori, Y; Nakano, S; Tsubokou, Y | 1 |
| Fujishima, M; Ibayashi, S; Kitayama, J; Kitazono, T; Ooboshi, H; Takada, J | 1 |
| Fatema, K; Hirono, O; Kaneko, K; Kubota, I; Nitobe, J; Shiga, R; Takeishi, Y | 1 |
| Iwao, H; Kawano, H; Kim, S; Zhan, Y | 1 |
| Abe, K; Kanazawa, M; Kohzuki, M; Kudo, K; Omata, K; Sato, M; Takeuchi, K; Tsunoda, K; Yasujima, M; Yoshida, K | 1 |
5 review(s) available for benidipine and Hypertension
| Article | Year |
|---|---|
Amlodipine Compared with Benidipine in the Management of Hypertension: A Systematic Review and Meta-Analysis.
Topics: Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Female; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Male; Middle Aged; Renal Insufficiency, Chronic; Risk Factors; Treatment Outcome; Vasodilator Agents | 2020 |
Renoprotective effects of the L-/T-type calcium channel blocker benidipine in patients with hypertension.
Topics: Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Humans; Hypertension; Kidney; Kidney Diseases | 2013 |
Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel, long-acting calcium channel blocker.
Topics: Angina Pectoris; Animals; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Calcium Channels, T-Type; Clinical Trials as Topic; Diabetic Nephropathies; Dihydropyridines; Drug Evaluation, Preclinical; Endothelial Cells; Heart; Humans; Hypertension; Kidney; Renal Circulation; Vasodilator Agents | 2006 |
[COPE trial].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Calcium Channel Blockers; Cardiovascular Diseases; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Japan; Male; Middle Aged; Randomized Controlled Trials as Topic; Sodium Chloride Symporter Inhibitors; Stroke | 2006 |
[Novel actions of calcium channel blockers].
Topics: Amlodipine; Animals; Azetidinecarboxylic Acid; Calcium Channel Blockers; Depression; Dihydropyridines; Evidence-Based Medicine; Heart Rate; Humans; Hypertension; Kidney Diseases; Proteinuria; Sympathetic Nervous System | 2006 |
41 trial(s) available for benidipine and Hypertension
| Article | Year |
|---|---|
Effects of Calcium-Channel Blocker Benidipine-Based Combination Therapy on Cardiac Events　- Subanalysis of the COPE Trial.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Drug Therapy, Combination; Female; Heart Diseases; Humans; Hypertension; Male; Middle Aged; Thiazides; Treatment Outcome | 2018 |
Effect of rifampin on enantioselective disposition and anti-hypertensive effect of benidipine.
Topics: Adult; Antihypertensive Agents; Area Under Curve; Biological Availability; Cross-Over Studies; Cytochrome P-450 CYP3A; Dihydropyridines; Dose-Response Relationship, Drug; Drug Interactions; Healthy Volunteers; Humans; Hypertension; Male; Rifampin; Stereoisomerism; Young Adult | 2019 |
Benidipine has effects similar to losartan on the central blood pressure and arterial stiffness in mild to moderate essential hypertension.
Topics: Adolescent; Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Essential Hypertension; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Vascular Stiffness | 2013 |
Combination therapy for hypertension in patients with CKD: a subanalysis of the Combination Therapy of Hypertension to Prevent Cardiovascular Events trial.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Renal Insufficiency, Chronic; Sodium Chloride Symporter Inhibitors; Treatment Outcome | 2013 |
Comparison of the antialbuminuric effects of benidipine and hydrochlorothiazide in Renin-Angiotensin System (RAS) inhibitor-treated hypertensive patients with albuminuria: the COSMO-CKD (COmbination Strategy on Renal Function of Benidipine or Diuretics Tr
Topics: Adult; Aged; Albuminuria; Amlodipine; Blood Pressure; Dihydropyridines; Female; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Renal Insufficiency, Chronic; Renin-Angiotensin System | 2014 |
Effects of the T/L-type calcium channel blocker benidipine on albuminuria and plasma aldosterone concentration. A pilot study involving switching from L-type calcium channel blockers to benidipine.
Topics: Aged; Albuminuria; Aldosterone; Blood Pressure; Calcium Channel Blockers; Creatinine; Dihydropyridines; Female; Glomerular Filtration Rate; Humans; Hypertension; Male; Middle Aged; Pilot Projects; Prospective Studies; Renin | 2014 |
Effects of calcium channel blocker-based combinations on intra-individual blood pressure variability: post hoc analysis of the COPE trial.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Diuretics; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Female; Heart Diseases; Humans; Hypertension; Male; Middle Aged; Prospective Studies; Risk Factors; Stroke; Thiazides | 2016 |
Improvements in Augmentation Index and Urinary Albumin Excretion With Benidipine in Hypertensive Patients With Chronic Kidney Disease.
Topics: Aged; Albuminuria; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Hypertension; Male; Prospective Studies; Renal Insufficiency, Chronic | 2016 |
Effects of calcium channel blocker benidipine-based combination therapy on target blood pressure control and cardiovascular outcome: a sub-analysis of the COPE trial.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Calcium Channel Blockers; Dihydropyridines; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Sodium Chloride Symporter Inhibitors; Treatment Outcome | 2017 |
Comparison of efficacy and safety between benidipine and hydrochlorothiazide in fosinopril-treated hypertensive patients with chronic kidney disease: protocol for a randomised controlled trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; China; Dihydropyridines; Diuretics; Double-Blind Method; Drug Therapy, Combination; Female; Fosinopril; Glomerular Filtration Rate; Humans; Hydrochlorothiazide; Hypertension; Kidney; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Proteinuria; Renal Insufficiency, Chronic; Research Design; Treatment Outcome; Young Adult | 2017 |
Effects of azelnidipine on the autonomic functions and its influence on arterial stiffness and endothelial functions.
Topics: Aged; Arteries; Autonomic Pathways; Azetidinecarboxylic Acid; Brachial Artery; Calcium Channel Blockers; Cross-Over Studies; Dihydropyridines; Double-Blind Method; Endothelium, Vascular; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Pulse; Vasodilation | 2008 |
Efficacy and safety of benidipine therapy of essential hypertension in elderly Chinese patients.
Topics: Aged; Albuminuria; Antihypertensive Agents; Arteries; Blood Pressure; China; Dihydropyridines; Female; Humans; Hypertension; Male | 2008 |
Comparison of the antiproteinuric effects of the calcium channel blockers benidipine and amlodipine administered in combination with angiotensin receptor blockers to hypertensive patients with stage 3-5 chronic kidney disease.
Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Calcium Channel Blockers; Dihydropyridines; Disease Progression; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Prospective Studies; Protective Agents; Proteinuria | 2009 |
A comparative study of the renoprotective effects of benidipine and valsartan in primary hypertensive patients with proteinuria.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Female; Glomerular Filtration Rate; Humans; Hypertension; Kidney Diseases; Male; Middle Aged; Proteinuria; Renal Circulation; Tetrazoles; Valine; Valsartan | 2009 |
Renoprotective effect of calcium channel blockers in combination with an angiotensin receptor blocker in elderly patients with hypertension. A randomized crossover trial between benidipine and amlodipine.
Topics: Aged; Aged, 80 and over; Albuminuria; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Imidazoles; Male; Renal Insufficiency, Chronic; Tetrazoles | 2010 |
[Renal protective effects of benidipine and valsartan in primary hypertension patients with proteinuria].
Topics: Adult; Aged; Angiotensin Receptor Antagonists; Calcium Channel Blockers; Dihydropyridines; Female; Glomerular Filtration Rate; Humans; Hypertension; Male; Middle Aged; Proteinuria; Tetrazoles; Valine; Valsartan | 2010 |
Comparison between the antiproteinuric effects of the calcium channel blockers benidipine and cilnidipine in combination with angiotensin receptor blockers in hypertensive patients with chronic kidney disease.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Creatinine; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Kidney; Kidney Failure, Chronic; Male; Proteinuria; Receptors, Angiotensin; Renal Insufficiency, Chronic | 2010 |
Benidipine reduces albuminuria and plasma aldosterone in mild-to-moderate stage chronic kidney disease with albuminuria.
Topics: Aged; Albuminuria; Aldosterone; Amlodipine; Angiotensin Receptor Antagonists; Blood Pressure; Calcium Channel Blockers; Chronic Disease; Diabetic Nephropathies; Dihydropyridines; Female; Glomerular Filtration Rate; Glomerulonephritis; Humans; Hypertension; Male; Middle Aged; Nephrosclerosis; Potassium; Severity of Illness Index; Sodium | 2011 |
Antihypertensive efficacy and safety of benidipine and its effects on cardiac structure and function in elderly Chinese patients with mild to moderate hypertension: an open-label, long-term study.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; China; Dihydropyridines; Echocardiography; Female; Heart; Heart Function Tests; Heart Rate; Humans; Hypertension; Hypertrophy, Left Ventricular; Kidney Function Tests; Male; Middle Aged; Myocardium; Patient Compliance; Prospective Studies | 2011 |
Prevention of cardiovascular events with calcium channel blocker-based combination therapies in patients with hypertension: a randomized controlled trial.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Calcium Channel Blockers; Dihydropyridines; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hypertension; Incidence; Japan; Kaplan-Meier Estimate; Male; Middle Aged; Outcome Assessment, Health Care; Prospective Studies; Risk Factors; Single-Blind Method; Sodium Chloride Symporter Inhibitors; Stroke; Treatment Outcome | 2011 |
Treatment of hypertension in patients 85 years of age or older: a J-BRAVE substudy.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cardiovascular Diseases; Dihydropyridines; Female; Humans; Hypertension; Japan; Male; Prospective Studies | 2011 |
Combination therapy for hypertension in the elderly: a sub-analysis of the Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) Trial.
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers; Cardiovascular Diseases; Dihydropyridines; Drug Therapy, Combination; Female; Humans; Hypertension; Incidence; Male; Middle Aged; Sodium Chloride Symporter Inhibitors; Treatment Outcome | 2012 |
Effects of benidipine hydrochloride on autonomic nervous activity in hypertensive patients with high- and low-salt diets.
Topics: Aged; Autonomic Nervous System; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm; Diet, Sodium-Restricted; Dihydropyridines; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Sodium, Dietary | 2003 |
Antihypertensive effects of long-acting calcium channel blockers on hemodialysis days--a randomized crossover trial between benidipine and nifedipine CR.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Cross-Over Studies; Delayed-Action Preparations; Dihydropyridines; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Nifedipine; Renal Dialysis | 2004 |
Antioxidative effects of benidipine hydrochloride in patients with hypertension independent of antihypertensive effects. Relationship between blood pressure and oxidative stress.
Topics: Aged; Antioxidants; Blood Pressure; Calcium Channel Blockers; Diabetes Complications; Diabetes Mellitus; Dihydropyridines; Female; Humans; Hypertension; Male; Myocardial Ischemia; Oxidative Stress; Risk Factors; Thiobarbituric Acid Reactive Substances | 2004 |
Effects of calcium antagonists in hypertensive patients with renal dysfunction: a prospective, randomized, parallel trial comparing benidipine and nifedipine.
Topics: Calcium Channel Blockers; Dihydropyridines; Disease Progression; Female; Humans; Hypertension; Hypertension, Renovascular; Male; Middle Aged; Nifedipine; Prospective Studies | 2004 |
Benidipine, a long-acting calcium channel blocker, inhibits oxidative stress in polymorphonuclear cells in patients with essential hypertension.
Topics: Aged; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Female; Flow Cytometry; Humans; Hypertension; Male; Middle Aged; Neutrophils; Oxidative Stress; Reactive Oxygen Species; Vasodilator Agents | 2005 |
Elevation of serum soluble E- and P-selectin in patients with hypertension is reversed by benidipine, a long-acting calcium channel blocker.
Topics: Blotting, Western; Calcium Channel Blockers; Case-Control Studies; Cell Adhesion Molecules; Dihydropyridines; E-Selectin; Female; Humans; Hypertension; Male; Middle Aged; P-Selectin | 2005 |
Long-term anti-hypertensive therapy with benidipine improves arterial stiffness over blood pressure lowering.
Topics: Adult; Antihypertensive Agents; Arteries; Blood Pressure; Calcium Channel Blockers; Diabetes Complications; Dihydropyridines; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nicardipine; Pulse; Regression Analysis | 2005 |
Effect of combination therapy of benidipine hydrochloride and candesartan cilexetil on serum lipid metabolism and blood pressure in elderly hypertensive patients with type 2 diabetes mellitus.
Topics: Aged; Aged, 80 and over; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Diabetes Mellitus, Type 2; Diastole; Dihydropyridines; Drug Therapy, Combination; Female; Heparin; Humans; Hypertension; Lipid Metabolism; Lipids; Lipoprotein Lipase; Male; Systole; Tetrazoles | 2006 |
Renoprotective effect and cost-effectiveness of using benidipine, a calcium channel blocker, to lower the dose of angiotensin receptor blocker in hypertensive patients with albuminuria.
Topics: Aged; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Calcium Channel Blockers; Cost-Benefit Analysis; Dihydropyridines; Dose-Response Relationship, Drug; Female; Humans; Hypertension; Kidney; Male; Middle Aged | 2007 |
Renal-protective effect of T-and L-type calcium channel blockers in hypertensive patients: an Amlodipine-to-Benidipine Changeover (ABC) study.
Topics: Aged; Amlodipine; Calcium Channel Blockers; Dihydropyridines; Female; Guideline Adherence; Humans; Hypertension; Kidney; Kidney Function Tests; Male; Middle Aged; Proteinuria; Pulse; Renin-Angiotensin System | 2007 |
Electron paramagnetic resonance investigation on modulatory effect of benidipine on membrane fluidity of erythrocytes in essential hypertension.
Topics: Administration, Oral; Aged; Antihypertensive Agents; Arginine; Blood Pressure; Blood Viscosity; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Erythrocyte Membrane; Female; Humans; Hypertension; Male; Membrane Fluidity; Middle Aged; Nitric Oxide; Treatment Outcome | 2008 |
Benidipine counteracts sodium-induced alterations in systemic and regional hemodynamics.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Dihydropyridines; Female; Hemodynamics; Humans; Hypertension; Male; Nifedipine; Regional Blood Flow; Single-Blind Method; Sodium, Dietary | 1997 |
Salt enhances responsiveness of terminal aortic vascular bed to sympathetic activity.
Topics: Aged; Aorta; Arginine Vasopressin; Calcium Channel Blockers; Diet, Sodium-Restricted; Dihydropyridines; Female; Hemodynamics; Humans; Hypertension; Male; Mesenteric Arteries; Norepinephrine; Prazosin; Renal Artery; Sodium Chloride, Dietary; Sympathetic Nervous System; Sympatholytics; Vascular Resistance | 1997 |
Effects of benidipine hydrochloride on 24-hour blood pressure and blood pressure response to mental stress in elderly patients with essential hypertension.
Topics: Administration, Oral; Aged; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm; Dihydropyridines; Female; Heart Rate; Humans; Hypertension; Male; Mental Processes; Middle Aged; Regression Analysis; Stress, Physiological | 1999 |
Improvement of insulin resistance in essential hypertension by long-acting Ca antagonist benidipine.
Topics: Apolipoproteins; Arteriosclerosis; Blood Glucose; Blood Platelets; Blood Pressure; Calcium; Calcium Channel Blockers; Catecholamines; Dihydropyridines; Female; Glucose Tolerance Test; Humans; Hypertension; Insulin; Insulin Resistance; Intracellular Fluid; Male; Middle Aged; Treatment Outcome | 1999 |
Long-term effect of antihypertensive therapy with calcium antagonist or angiotensin converting enzyme inhibitor on serum nitrite/nitrate levels in human essential hypertension.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Endothelium, Vascular; Female; Humans; Hypertension; Indoles; Kidney Function Tests; Lipids; Male; Middle Aged; Nitrates; Nitrites | 2000 |
Effect of the calcium antagonist benidipine hydrochloride on 24-h ambulatory blood pressure in patients with mild to moderate hypertension in a double-blind study against placebo.
Topics: Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Pulse | 2000 |
Clinical trial of benidipine in mild to moderate hypertension.
Topics: Adult; Aged; Blood Pressure Determination; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; Reference Values; Severity of Illness Index; Treatment Outcome | 1999 |
Effects of short- and long-acting calcium channel blockers on the relationship between blood pressure and physical activity.
Topics: Adult; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Circadian Rhythm; Cross-Over Studies; Dihydropyridines; Exercise; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Systole | 2001 |
35 other study(ies) available for benidipine and Hypertension
| Article | Year |
|---|---|
Gingival enlargement improvement following medication change from amlodipine to benidipine and periodontal therapy.
Topics: Amlodipine; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Female; Gingival Hyperplasia; Gingival Overgrowth; Humans; Hypertension | 2022 |
Effects of an Antihypertensive Combination in Japanese Hypertensive Outpatients Based on the Long-acting Calcium Channel Blocker Benidipine on Vascular and Renal Events: A Sub-analysis of the COPE Trial
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Drug Therapy, Combination; Humans; Hypertension; Japan; Outpatients | 2020 |
Effects of a benidipine-based combination therapy on the risk of stroke according to stroke subtype: the COPE trial.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Atrial Fibrillation; Atrial Flutter; Blood Pressure; Brain Ischemia; Dihydropyridines; Diuretics; Drug Therapy, Combination; Female; Follow-Up Studies; Heart Rate; Humans; Hypertension; Intracranial Hemorrhages; Kaplan-Meier Estimate; Male; Middle Aged; Risk Factors; Stroke; Survival Analysis; Vasodilator Agents | 2013 |
Effects of benidipine, a long-acting T-type calcium channel blocker, on home blood pressure and renal function in patients with essential hypertension: a retrospective, 'real-world' comparison with amlodipine.
Topics: Adult; Aged; Albuminuria; Amlodipine; Blood Pressure; Calcium Channel Blockers; Calcium Channels, T-Type; Dihydropyridines; Female; Glomerular Filtration Rate; Humans; Hypertension; Male; Middle Aged; Retrospective Studies | 2009 |
Benidipine, a dihydropyridine L-type/T-type calcium channel blocker, affords additive benefits for prevention of cardiorenal injury in hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Enzyme-Linked Immunosorbent Assay; Heart; Heart Rate; Hypertension; Kidney; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2010 |
Effects of combination therapy with angiotensin II type I receptor blockers and calcium channel blockers on renal function in hypertensive patients/a retrospective, "real-world" comparative study.
Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Calcium Channel Blockers; Creatinine; Dihydropyridines; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Humans; Hypertension; Kaplan-Meier Estimate; Kidney; Kidney Diseases; Kidney Function Tests; Male; Middle Aged; Nifedipine; Proportional Hazards Models; Retrospective Studies; Survival Analysis; Treatment Outcome | 2010 |
Ca(2+) channel blocker benidipine promotes coronary angiogenesis and reduces both left-ventricular diastolic stiffness and mortality in hypertensive rats.
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Coronary Circulation; Diastole; Dihydropyridines; Heart Failure; Heart Ventricles; Hypertension; Male; Neovascularization, Physiologic; Nitrendipine; Rats; Rats, Inbred Dahl | 2010 |
Effect of antihypertensive treatment on cardiovascular events in elderly hypertensive patients: Japan's Benidipine Research on Antihypertensive Effects in the Elderly (J-BRAVE).
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cardiovascular Diseases; Dihydropyridines; Female; Humans; Hypertension; Japan; Male; Prospective Studies; Risk Factors | 2011 |
Is there an optimal combination of antihypertensives for preventing cardiovascular events?
Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Calcium Channel Blockers; Dihydropyridines; Female; Humans; Hypertension; Male; Sodium Chloride Symporter Inhibitors; Stroke | 2011 |
Combination treatment with a calcium channel blocker and an angiotensin blocker in a rat systolic heart failure model with hypertension.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Blood Pressure; Calcium Channel Blockers; Cilazapril; Dihydropyridines; Drug Therapy, Combination; Heart Failure; Hypertension; Kidney; Natriuretic Peptide, Brain; Organ Size; Rats; Receptor, Angiotensin, Type 1; RNA, Messenger; Survival Rate; Systole; Transforming Growth Factor beta | 2002 |
Hyperkalemia induced by the calcium channel blocker, benidipine.
Topics: Aged; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Hyperkalemia; Hypertension; Risk Assessment; Severity of Illness Index | 2003 |
Effects of benidipine and candesartan on kidney and vascular function in hypertensive Dahl rats.
Topics: Albuminuria; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Drug Therapy, Combination; Hypertension; Kidney; Male; Mesenteric Artery, Superior; Rats; Rats, Inbred Dahl; Tetrazoles; Vasodilation; Vasodilator Agents | 2003 |
[Effect of benidipine on plasma level of calcitonin gene-related peptide in essential hypertension].
Topics: Adult; Aged; Calcitonin Gene-Related Peptide; Calcium Channel Blockers; Dihydropyridines; Female; Humans; Hypertension; Male; Middle Aged | 2004 |
Benidipine improves oxidized LDL-dependent monocyte and endothelial dysfunction in hypertensive patients with type 2 diabetes mellitus.
Topics: Aged; Autoantibodies; Biomarkers; Diabetes Mellitus, Type 2; Dihydropyridines; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Hypertension; Lipoproteins, LDL; Male; Middle Aged; Monocytes; Oxidation-Reduction; Retrospective Studies; Time Factors; Vasodilator Agents | 2005 |
A calcium-channel blocker, benidipine, improves forearm reactive hyperemia in patients with essential hypertension.
Topics: Aged; Blood Flow Velocity; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Endothelium, Vascular; Forearm; Hepatocyte Growth Factor; Humans; Hyperemia; Hypertension; Middle Aged; Nitroglycerin; Time Factors; Vasodilator Agents | 2005 |
Effects of benidipine, a long-lasting dihydropyridine-Ca2+ channel blocker, on cerebral blood flow autoregulation in spontaneously hypertensive rats.
Topics: Administration, Oral; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Blood Flow Velocity; Blood Gas Analysis; Blood Pressure; Calcium Channel Blockers; Carbon Dioxide; Cerebral Cortex; Dihydropyridines; Hypertension; Male; Oxygen; Rats; Rats, Inbred SHR; Rats, Wistar; Species Specificity; Tetrazoles; Ultrasonography, Doppler, Pulsed; Vascular Resistance | 2006 |
Up-regulation of muscle uncoupling protein 3 gene expression by calcium channel blocker, benidipine hydrochloride in rats.
Topics: Adipose Tissue, Brown; Animals; Blood Pressure; Body Weight; Calcium Channel Blockers; Dihydropyridines; Gene Expression; Hydrochloric Acid; Hypertension; Ion Channels; Male; Mitochondrial Proteins; Muscle, Skeletal; Rats; Rats, Inbred SHR; Rats, Wistar; Thermogenesis; Uncoupling Protein 1; Uncoupling Protein 3; Up-Regulation | 2007 |
Effect of benidipine hydrochloride, a long-acting T-type calcium channel blocker, on blood pressure and renal function in hypertensive patients with diabetes mellitus. Analysis after switching from cilnidipine to benidipine.
Topics: Aged; Blood Pressure; Calcium Channel Blockers; Calcium Channels, T-Type; Diabetes Complications; Dihydropyridines; Female; Humans; Hypertension; Kidney; Kidney Function Tests; Male; Proteinuria; Retrospective Studies | 2007 |
Benidipine, an anti-hypertensive drug, inhibits reactive oxygen species production in polymorphonuclear leukocytes and oxidative stress in salt-loaded stroke-prone spontaneously hypertensive rats.
Topics: Animals; Antioxidants; Calcium; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; HL-60 Cells; Humans; Hypertension; Male; NADP; Neutrophils; Oxidative Stress; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Sodium Chloride, Dietary; Stroke | 2008 |
Effects of benidipine on renal function in anesthetized spontaneously hypertensive rats.
Topics: Anesthesia; Animals; Calcium Channel Blockers; Dihydropyridines; Electrolytes; Glomerular Filtration Rate; Hypertension; Kidney; Kidney Function Tests; Kidney Tubules; Lithium; Male; Rats; Rats, Inbred SHR; Renal Plasma Flow; Urodynamics | 1994 |
[Effect of calcium antagonist (benidipine) and alpha 1 blocker (urapidil) on renal hemodynamic responses to two acute environmental stresses in spontaneously hypertensive rats (SHR)].
Topics: Acute Disease; Adrenergic alpha-Antagonists; Animals; Calcium Channel Blockers; Dihydropyridines; Female; Hypertension; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Stress, Physiological; Vascular Resistance | 1994 |
Benidipine improves endothelial function in renal resistance arteries of hypertensive rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Endothelium, Vascular; Heart Rate; Hypertension; In Vitro Techniques; Male; Muscle Relaxation; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Artery; Time Factors; Todralazine; Vascular Resistance | 1996 |
Suppressive effects of benidipine on the development of hypertension and renal lesions in salt-loaded stroke-prone spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cerebrovascular Disorders; Dihydropyridines; Hypertension; Kidney; Male; Organ Size; Rats; Rats, Inbred SHR | 1995 |
Effects of benidipine hydrochloride on antioxidant enzyme activity in stroke-prone spontaneous hypertensive rats (SHR-SP).
Topics: Animals; Antioxidants; Blood Pressure; Calcium Channel Blockers; Catalase; Cerebrovascular Disorders; Creatine; Dihydropyridines; Drug Therapy, Combination; Glutathione Peroxidase; Hydralazine; Hydrochlorothiazide; Hypertension; Kidney; Male; Organ Size; Oxidoreductases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reserpine; Superoxide Dismutase | 1997 |
Relationship between plasma concentration and antihypertensive effect of the dihydropyridine calcium antagonist, benidipine, in rats.
Topics: Administration, Oral; Animals; Area Under Curve; Calcium Channel Blockers; Dihydropyridines; Half-Life; Hypertension; Injections, Intravenous; Male; Molecular Structure; Rats; Rats, Inbred SHR; Rats, Wistar; Species Specificity; Splanchnic Circulation | 1997 |
Effects of a novel calcium antagonist, benidipine hydrochloride, on platelet responsiveness to mental stress in patients with essential hypertension.
Topics: Adult; Aged; beta-Thromboglobulin; Blood Platelets; Calcium Channel Blockers; Dihydropyridines; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Stress, Psychological | 1999 |
[Effects of benidipine hydrochloride (Coniel) on blood pressure, heart rate and plasma norepinephrine concentration in spontaneously hypertensive rats].
Topics: Amlodipine; Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Heart Rate; Hypertension; Male; Nifedipine; Norepinephrine; Rats; Rats, Inbred SHR | 1999 |
Is there any difference between intermediate-acting and long-acting calcium antagonists in diurnal blood pressure and autonomic nervous activity in hypertensive coronary artery disease patients?
Topics: Autonomic Nervous System; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Circadian Rhythm; Coronary Disease; Delayed-Action Preparations; Dihydropyridines; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine; Treatment Outcome | 2000 |
New approach for measurement of sympathetic nervous abnormality in conscious, spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Dihydropyridines; Heart Rate; Hypertension; Male; Norepinephrine; Propranolol; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sympathetic Nervous System | 2000 |
Possible involvement of endothelin-1 in cardioprotective effects of benidipine.
Topics: Animals; Animals, Newborn; Calcium Channel Blockers; Cardiomegaly; Cells, Cultured; Dihydropyridines; Endothelin-1; Hypertension; Leucine; Muscle Fibers, Skeletal; Myocardium; Nifedipine; Rats; Rats, Wistar; Thymidine; Tritium | 2000 |
Benidipine inhibits expression of ET-1 and TGF-beta1 in Dahl salt-sensitive hypertensive rats.
Topics: Animals; Blood Pressure; Blotting, Western; Calcium Channel Blockers; Dihydropyridines; Endothelin-1; Endothelins; Gene Expression; Heart Ventricles; Hypertension; Male; Myocardium; Organ Size; Protein Precursors; Rats; Rats, Inbred Dahl; Receptor, Endothelin A; Receptors, Endothelin; RNA, Messenger; Sodium Chloride, Dietary; Transforming Growth Factor beta; Transforming Growth Factor beta1; Ventricular Remodeling | 2001 |
Long-term effects of benidipine on cerebral vasoreactivity in hypertensive rats.
Topics: Acetylcholine; Amides; Animals; Basilar Artery; Body Weight; Calcium Channel Blockers; Cerebral Arteries; Dihydropyridines; Dose-Response Relationship, Drug; Hypertension; Male; Muscle Relaxants, Central; Nitric Oxide Donors; Nitroprusside; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Vasodilation; Vasodilator Agents | 2002 |
Long-term effects of benidipine hydrochloride on severe left ventricular hypertrophy and collagen metabolism in patients with essential hypertension.
Topics: Administration, Oral; Aged; Calcium Channel Blockers; Collagen; Dihydropyridines; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Matrix Metalloproteinase 1; Middle Aged; Tissue Inhibitor of Metalloproteinase-1 | 2002 |
Enhancement of glomerular platelet-derived growth factor beta-receptor tyrosine phosphorylation in hypertensive rats and its inhibition by calcium channel blocker.
Topics: Albuminuria; Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Genetic Predisposition to Disease; Hypertension; Kidney Glomerulus; Male; Phosphorylation; Proteinuria; Rats; Rats, Inbred Dahl; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Platelet-Derived Growth Factor beta; Stroke; Tyrosine | 2002 |
Calcium channel blockers reverse the sustained elevation of blood pressure induced by chronic infusion of endothelin in conscious rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Endothelins; Hypertension; Male; Nifedipine; Peptides; Rats; Rats, Inbred Strains; Sodium | 1990 |