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benfluorex and Obesity

benfluorex has been researched along with Obesity in 20 studies

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
"3 ng/mL, means +/- SE), the clinical and metabolic effects of benfluorex (B), a lipid-lowering drug able to improve insulin sensitivity."9.08Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo. ( Camisasca, R; Cassisa, C; Pacchioni, M; Piatti, PM; Pontiroli, AE; Pozza, G, 1996)
"To evaluate the change in lipids and insulin sensitivity in 10 obese type II diabetic patients after treatment with benfluorex or placebo for 2 wk."9.07Effects of benfluorex on insulin resistance and lipid metabolism in obese type II diabetic patients. ( Bianchi, R; Bongers, V; Bravenboer, B; Erkelens, DW, 1993)
"3 ng/mL, means +/- SE), the clinical and metabolic effects of benfluorex (B), a lipid-lowering drug able to improve insulin sensitivity."5.08Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo. ( Camisasca, R; Cassisa, C; Pacchioni, M; Piatti, PM; Pontiroli, AE; Pozza, G, 1996)
"To evaluate the change in lipids and insulin sensitivity in 10 obese type II diabetic patients after treatment with benfluorex or placebo for 2 wk."5.07Effects of benfluorex on insulin resistance and lipid metabolism in obese type II diabetic patients. ( Bianchi, R; Bongers, V; Bravenboer, B; Erkelens, DW, 1993)
" Benfluorex treatment improves insulin sensitivity and has antihyperglycemic and hypolipidemic effects in human beings and in experimental animals."4.78[Mode of action of benfluorex. Recent data]. ( Brindley, DN, 1992)
" Body weight, insulin, and leptin were decreased (p < 0."3.76MR molecular imaging of aortic angiogenesis. ( Cai, K; Caruthers, SD; Huang, W; Lanza, GM; Wickline, SA; Williams, TA; Winter, PM; Zhang, H, 2010)
" Benfluorex has both anorectic and metabolic effects that lower body weight and improve insulin sensitivity in obesity and type 2 diabetes."3.69Antiatherogenic effects of long-term benfluorex treatment in male insulin resistant JCR:LA-cp rats. ( Amy, RM; Brindley, DN; Dolphin, PJ; Graham, SE; Russell, JC; Wood, GO, 1997)
"Rats of the JCR:LA-corpulent strain were treated with benfluorex daily at a dose of 25 mg/kg body weight."3.68Decreased serum lipids, serum insulin and triacylglycerol synthesis in adipose tissue of JCR:LA-corpulent rats treated with benfluorex. ( al-Sieni, AI; Brindley, DN; Hales, P; Russell, JC, 1991)
"Benfluorex + insulin is a valid alternative for obese patients who remain poorly controlled despite insulin or who require high doses of insulin."2.69Added benfluorex in obese insulin-requiring type 2 diabetes. ( Bauduceau, B; Brun, JM; Guillon-Metz, F; Leutenegger, M; Martin, C; Nicolino-Peltier, C; Richard, JL; Vannereau, D, 1998)
"Benfluorex hydrochloride has known lipid- and glucose-lowering effects."2.67Benfluorex decreases insulin resistance and improves lipid profiles in obese type 2 diabetic patients. ( Bianchi, R; Bongers, V; Bravenboer, B; Erkelens, DW, 1993)
"Benfluorex was well tolerated by all patients and no adverse event was reported."2.66Effects of benfluorex in obese patients with metabolic disorders. ( di Martino, G; Federico, P; Jacono, G; Mattera, E, 1989)
"Benfluorex treatment and pair feeding decreased serum triacylglycerol concentrations by about 50%; there was a preferential loss of triacylglycerols containing longer chain fatty acids in the males, whereas this selectivity was not seen in the females."1.29Effects of benfluorex on serum triacylglycerols and insulin sensitivity in the corpulent rat. ( Brindley, DN; Dolphin, PJ; Graham, SE; Russell, JC, 1996)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19902 (10.00)18.7374
1990's11 (55.00)18.2507
2000's0 (0.00)29.6817
2010's7 (35.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tribouilloy, C3
Maréchaux, S2
Jobic, Y2
Jeu, A1
Ederhy, S1
Donal, E1
Réant, P1
Arnalsteen, E1
Boulanger, J1
Garban, T1
Ennezat, PV2
Andréjak, M2
Rusinaru, D2
Malergue, MC1
Bruneval, P1
Czitrom, D1
Henon, P2
Tribouilloy, L1
Leleu, F1
Sevestre, H1
Peltier, M1
Caus, T1
Cai, K1
Caruthers, SD1
Huang, W1
Williams, TA1
Zhang, H1
Wickline, SA1
Lanza, GM1
Winter, PM1
Le Ven, F1
Habib, G1
Gueffet, JP1
Eicher, JC1
Blanchard-Lemoine, B1
Rousseau, J1
Etienne, Y1
Nau, JY2
Bianchi, R2
Bongers, V2
Bravenboer, B2
Erkelens, DW2
Brindley, DN5
Pontiroli, AE1
Pacchioni, M1
Piatti, PM1
Cassisa, C1
Camisasca, R1
Pozza, G1
Russell, JC3
Graham, SE2
Dolphin, PJ2
Amy, RM1
Wood, GO1
Leutenegger, M1
Bauduceau, B1
Brun, JM2
Guillon-Metz, F1
Martin, C1
Nicolino-Peltier, C1
Richard, JL1
Vannereau, D1
Chaine, B1
Morand, JJ1
Folchetti, G1
Hesse, S1
Jean-Pastor, MJ1
Bonerandi, JJ1
Asmal, AC1
Leary, WP1
Deppe, W1
Lockett, CJ1
Hales, P1
al-Sieni, AI1
di Martino, G1
Federico, P1
Mattera, E1
Jacono, G1

Reviews

2 reviews available for benfluorex and Obesity

ArticleYear
Mechanisms for the effects of benfluorex on the obese-diabetic-dyslipidemic syndrome.
    Diabetes/metabolism reviews, 1993, Volume: 9 Suppl 1

    Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fenfluramine; Humans; Hyperlipidemias; Hypogl

1993
[Mode of action of benfluorex. Recent data].
    Presse medicale (Paris, France : 1983), 1992, Sep-09, Volume: 21, Issue:28

    Topics: Animals; Arteriosclerosis; Diabetes Mellitus, Type 2; Drug Interactions; Fatty Acids; Female; Fenflu

1992

Trials

6 trials available for benfluorex and Obesity

ArticleYear
Benfluorex decreases insulin resistance and improves lipid profiles in obese type 2 diabetic patients.
    Diabetes/metabolism reviews, 1993, Volume: 9 Suppl 1

    Topics: Adult; Blood Glucose; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind Method;

1993
Effects of benfluorex on insulin resistance and lipid metabolism in obese type II diabetic patients.
    Diabetes care, 1993, Volume: 16, Issue:4

    Topics: Apolipoprotein A-I; Apolipoproteins B; Appetite Depressants; Blood Glucose; C-Peptide; Cholesterol;

1993
Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo.
    The Journal of clinical endocrinology and metabolism, 1996, Volume: 81, Issue:10

    Topics: 3-Hydroxybutyric Acid; Appetite Depressants; Body Weight; C-Peptide; Diabetes Mellitus; Diabetes Mel

1996
Added benfluorex in obese insulin-requiring type 2 diabetes.
    Diabetes & metabolism, 1998, Volume: 24, Issue:1

    Topics: Adolescent; Adult; Aged; Blood Glucose; Body Weight; C-Peptide; Diabetes Mellitus; Diabetes Mellitus

1998
[Antidiabetic efficacy of benfluorex. Clinical data].
    Presse medicale (Paris, France : 1983), 1992, Sep-09, Volume: 21, Issue:28

    Topics: Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Female; Fenfluramine; Humans; Hypolipidemic A

1992
Effects of benfluorex in obese patients with metabolic disorders.
    The British journal of clinical practice, 1989, Volume: 43, Issue:6

    Topics: Blood Glucose; Female; Fenfluramine; Hormones; Humans; Hypolipidemic Agents; Lipids; Male; Metabolic

1989

Other Studies

12 other studies available for benfluorex and Obesity

ArticleYear
Frequency of drug-induced valvular heart disease in patients previously exposd to benfluorex: a multicentre prospective study.
    European heart journal, 2013, Volume: 34, Issue:46

    Topics: Analysis of Variance; Aortic Valve Insufficiency; Appetite Depressants; Case-Control Studies; Diabet

2013
Fatal dynamic mitral regurgitation as a presentation of benfluorex-Induced valvular heart toxicity.
    International journal of cardiology, 2015, Apr-01, Volume: 184

    Topics: Aged; Appetite Depressants; Autopsy; Echocardiography; Fatal Outcome; Fenfluramine; Heart Valve Pros

2015
Restrictive organic mitral regurgitation associated with benfluorex therapy.
    European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 2010, Volume: 11, Issue:7

    Topics: Aged; Appetite Depressants; Body Mass Index; Cardiomyopathy, Restrictive; Diabetes Mellitus; Drug Th

2010
MR molecular imaging of aortic angiogenesis.
    JACC. Cardiovascular imaging, 2010, Volume: 3, Issue:8

    Topics: Animals; Aorta; Appetite Depressants; Atherosclerosis; Body Weight; Cholesterol; Disease Models, Ani

2010
Valvular heart disease associated with benfluorex therapy: results from the French multicentre registry.
    European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 2011, Volume: 12, Issue:4

    Topics: Appetite Depressants; Body Mass Index; Comorbidity; Dose-Response Relationship, Drug; Echocardiograp

2011
[What were the indications for the Mediator in 1979?].
    Revue medicale suisse, 2011, Feb-09, Volume: 7, Issue:281

    Topics: Anxiety; Appetite Depressants; Diabetes Mellitus, Type 2; Fenfluramine; France; Heart Valve Diseases

2011
[The French are wary of their drugs].
    Revue medicale suisse, 2011, May-25, Volume: 7, Issue:296

    Topics: Appetite Depressants; Body Mass Index; Cause of Death; Drugs, Generic; Fenfluramine; France; Heart V

2011
Effects of benfluorex on serum triacylglycerols and insulin sensitivity in the corpulent rat.
    Canadian journal of physiology and pharmacology, 1996, Volume: 74, Issue:8

    Topics: Animals; Body Weight; Disease Models, Animal; Eating; Female; Fenfluramine; Hypolipidemic Agents; In

1996
Antiatherogenic effects of long-term benfluorex treatment in male insulin resistant JCR:LA-cp rats.
    Atherosclerosis, 1997, Jul-25, Volume: 132, Issue:2

    Topics: Animals; Arteriosclerosis; Fenfluramine; Hypolipidemic Agents; Insulin Resistance; Male; Obesity; Ra

1997
[Urticaria and anaphylactic shock from benfluorex. Two case reports].
    Annales de dermatologie et de venereologie, 1998, Volume: 125, Issue:3

    Topics: Adverse Drug Reaction Reporting Systems; Anaphylaxis; Appetite Depressants; Female; Fenfluramine; Fr

1998
The effects of benfluramate on carbohydrate metabolism in obesity.
    Research communications in chemical pathology and pharmacology, 1977, Volume: 18, Issue:1

    Topics: Adult; Blood Glucose; Body Weight; Carbohydrate Metabolism; Female; Fenfluramine; Humans; Kinetics;

1977
Decreased serum lipids, serum insulin and triacylglycerol synthesis in adipose tissue of JCR:LA-corpulent rats treated with benfluorex.
    Biochimica et biophysica acta, 1991, Aug-20, Volume: 1085, Issue:1

    Topics: Adipose Tissue; Animals; Body Weight; Feeding Behavior; Female; Fenfluramine; Glucose; Hormones; Hyp

1991