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benfluorex and Heart Valve Diseases

benfluorex has been researched along with Heart Valve Diseases in 31 studies

Heart Valve Diseases: Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).

Research Excerpts

ExcerptRelevanceReference
"The authors describe the case of a simultaneous mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy in a 40-year-old woman."7.78Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy. ( Ayme-Dietrich, E; Bischoff, N; Dallemand, R; Gasser, B; Lawson, R; Monassier, L, 2012)
"Benfluorex is a fenfluramine derivative which has been marketed between 1976 and 2009."5.46Fatal postoperative systemic pulmonary hypertension in benfluorex-induced valvular heart disease surgery: A case report. ( Banfi, C; Baufreton, C; Bruneval, P; Ennezat, PV; Fouquet, O; Giraud, R; Rousselet, MC, 2017)
"Adjusted RR for mitral insufficiency and aortic insufficiency admissions were 2."5.36Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus. ( Allemand, H; Fagot, JP; Montastruc, JL; Neumann, A; Païta, M; Ricordeau, P; Simon, D; Tuppin, P; Weill, A, 2010)
"The authors describe the case of a simultaneous mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy in a 40-year-old woman."3.78Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy. ( Ayme-Dietrich, E; Bischoff, N; Dallemand, R; Gasser, B; Lawson, R; Monassier, L, 2012)
" As a derivative of fenfluramine with an appetite suppressant action, benfluorex is preferentially used in overweight patients."3.75Fenfluramine-like cardiovascular side-effects of benfluorex. ( Boutet, K; Carlhant-Kowalski, D; Frachon, I; Gut-Gobert, C; Humbert, M; Jobic, Y; Leroyer, C; Simonneau, G; Sitbon, O, 2009)
" Further studies should be conducted to determine the subsequent course of benfluorex-induced VHD and PAH, and to identify genetic, biological and clinical factors that determine individual susceptibility to developing such adverse effects."2.50Adverse effects of benfluorex on heart valves and pulmonary circulation. ( Andréjak, M; Maréchaux, S; Peltier, M; Szymanski, C; Tribouilloy, C, 2014)
"Benfluorex is a fenfluramine derivative which has been marketed between 1976 and 2009."1.46Fatal postoperative systemic pulmonary hypertension in benfluorex-induced valvular heart disease surgery: A case report. ( Banfi, C; Baufreton, C; Bruneval, P; Ennezat, PV; Fouquet, O; Giraud, R; Rousselet, MC, 2017)
"Benfluorex is a fenfluramine derivative approved for the treatment of metabolic syndrome and type 2 diabetes mellitus."1.37Mitral and aortic valvular disease associated with benfluorex use. ( Castellant, P; Etienne, Y; Fatemi, M; Frachon, I; Jobic, Y; Quintin-Roué, I, 2011)
"Benfluorex is an amphetamine appetite suppressant derived from fenfluramine."1.36Benfluorex: increasing reports of valve disorders. ( , 2010)
"Adjusted RR for mitral insufficiency and aortic insufficiency admissions were 2."1.36Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus. ( Allemand, H; Fagot, JP; Montastruc, JL; Neumann, A; Païta, M; Ricordeau, P; Simon, D; Tuppin, P; Weill, A, 2010)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (9.68)29.6817
2010's28 (90.32)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dyer, O1
Szymanski, C2
Andréjak, M1
Peltier, M1
Maréchaux, S3
Tribouilloy, C3
Rusinaru, D1
Jobic, Y7
Ederhy, S1
Donal, E1
Réant, P1
Arnalsteen, E1
Boulanger, J1
Garban, T1
Ennezat, PV3
Jeu, A1
Plurien, F1
Bruneval, P2
Iung, B1
Le Ven, F2
Alavi, Z1
Etienne, Y4
Didier, R1
Porcher, R1
Baufreton, C1
Rousselet, MC1
Fouquet, O1
Giraud, R1
Banfi, C1
Boutet, K1
Frachon, I3
Gut-Gobert, C1
Leroyer, C2
Carlhant-Kowalski, D1
Sitbon, O1
Simonneau, G1
Humbert, M2
Le Gal, G1
Gueffet, JP2
Piriou, N1
Trochu, JN1
Weill, A1
Païta, M1
Tuppin, P1
Fagot, JP1
Neumann, A1
Simon, D1
Ricordeau, P1
Montastruc, JL1
Allemand, H1
Droogmans, S1
Cosyns, B1
Van Camp, G1
Habib, G2
Eicher, JC1
Blanchard-Lemoine, B1
Rousseau, J1
Hénon, P1
Mullard, A1
Nau, JY2
Fatemi, M1
Castellant, P1
Quintin-Roué, I1
Boudes, A1
Lavoute, C1
Avierinos, JF1
Le Dolley, Y1
Villacampa, C1
Salem, A1
Loundou, AD1
Michel, N1
Renard, S1
Fournier, A1
Zureik, M1
Ayme-Dietrich, E1
Lawson, R1
Gasser, B1
Dallemand, R1
Bischoff, N1
Monassier, L1
Benkimoun, P1
Derumeaux, G1
Ernande, L1
Serusclat, A1
Servan, E1
Bruckert, E1
Rousset, H1
Senn, S1
Van Gaal, L1
Picandet, B1
Gavini, F1
Moulin, P1
Watson, R1
Rafel Ribera, J1
Casañas Muñoz, R1
Anguera Ferrando, N1
Batalla Sahún, N1
Castro Cels, A1
Pujadas Capmany, R1

Reviews

1 review available for benfluorex and Heart Valve Diseases

ArticleYear
Adverse effects of benfluorex on heart valves and pulmonary circulation.
    Pharmacoepidemiology and drug safety, 2014, Volume: 23, Issue:7

    Topics: Echocardiography; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Hypertension, Pulmonary;

2014

Trials

1 trial available for benfluorex and Heart Valve Diseases

ArticleYear
Echocardiographic evidence for valvular toxicity of benfluorex: a double-blind randomised trial in patients with type 2 diabetes mellitus.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Aged; Diabetes Mellitus, Type 2; Echocardiography; Female; Fenfluramine; Glycated Hemoglobin; Heart

2012

Other Studies

29 other studies available for benfluorex and Heart Valve Diseases

ArticleYear
France to prosecute its drug regulator and Servier in scandal over diabetes drug.
    BMJ (Clinical research ed.), 2017, 09-11, Volume: 358

    Topics: Drug and Narcotic Control; Drug Industry; Fenfluramine; France; Fraud; Heart Valve Diseases; Homicid

2017
Benfluorex and cardiac valve disease: long delay in publication.
    Prescrire international, 2013, Volume: 22, Issue:135

    Topics: Access to Information; Appetite Depressants; Fenfluramine; Heart Valve Diseases; Heart Valves; Human

2013
Exposure to benfluorex: left heart valve disease very common.
    Prescrire international, 2013, Volume: 22, Issue:140

    Topics: Echocardiography; Fenfluramine; France; Heart Valve Diseases; Humans; Hypolipidemic Agents; Safety-B

2013
Identifying drug-related disorders: a probabilistic approach.
    Prescrire international, 2013, Volume: 22, Issue:144

    Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Probability

2013
Benfluorex: left heart valve disease very common.
    Prescrire international, 2014, Volume: 23, Issue:149

    Topics: Appetite Depressants; Echocardiography; Fenfluramine; France; Heart Valve Diseases; Humans

2014
Food and Drug Administration criteria for the diagnosis of drug-induced valvular heart disease in patients previously exposed to benfluorex: a prospective multicentre study.
    European heart journal. Cardiovascular Imaging, 2015, Volume: 16, Issue:2

    Topics: Aged; Appetite Depressants; Case-Control Studies; Echocardiography, Doppler; Female; Fenfluramine; H

2015
Calcifications in benfluorex-induced valve heart disease: a misknown association.
    Cardiology, 2015, Volume: 130, Issue:2

    Topics: Aged; Aortic Valve Insufficiency; Appetite Depressants; Calcinosis; Fenfluramine; Heart Valve Diseas

2015
Drug-Induced- or Rheumatic- Valvular Heart Disease in Patients Exposed to Benfluorex?
    PloS one, 2016, Volume: 11, Issue:8

    Topics: Aged; Appetite Depressants; Female; Fenfluramine; France; Heart Valve Diseases; Humans; Male; Markov

2016
Fatal postoperative systemic pulmonary hypertension in benfluorex-induced valvular heart disease surgery: A case report.
    Medicine, 2017, Volume: 96, Issue:2

    Topics: Appetite Depressants; Fatal Outcome; Female; Fenfluramine; Heart Valve Diseases; Heart Valve Prosthe

2017
Fenfluramine-like cardiovascular side-effects of benfluorex.
    The European respiratory journal, 2009, Volume: 33, Issue:3

    Topics: Appetite Depressants; Cardiovascular Diseases; Diabetes Mellitus; Female; Fenfluramine; Heart Valve

2009
Benfluorex: negative data in France, but still on the market. Neuropsychiatric disorders, pulmonary hypertension and heart valve damage.
    Prescrire international, 2009, Volume: 18, Issue:101

    Topics: Appetite Depressants; Fenfluramine; France; Heart Valve Diseases; Humans; Hypertension, Pulmonary; N

2009
Benfluorex and unexplained valvular heart disease: a case-control study.
    PloS one, 2010, Apr-12, Volume: 5, Issue:4

    Topics: Aged; Case-Control Studies; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypolipidemic Agents

2010
Benfluorex: increasing reports of valve disorders.
    Prescrire international, 2010, Volume: 19, Issue:105

    Topics: Appetite Depressants; Fenfluramine; France; Heart Valve Diseases; Humans; Hypertension, Pulmonary; P

2010
Valvular heart disease associated with benfluorex.
    Archives of cardiovascular diseases, 2010, Volume: 103, Issue:5

    Topics: Appetite Depressants; Diuretics; Echocardiography, Doppler, Color; Female; Fenfluramine; Furosemide;

2010
Benfluorex: yet more valve disorders.
    Prescrire international, 2010, Volume: 19, Issue:107

    Topics: Fenfluramine; Heart Valve Diseases; Humans; Hypolipidemic Agents

2010
Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus.
    Pharmacoepidemiology and drug safety, 2010, Volume: 19, Issue:12

    Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Cohort Studies; Databases, Factual; D

2010
Benfluorex: the last chapter of drug-induced valvular heart disease?
    European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 2011, Volume: 12, Issue:4

    Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Appetite Depressants; Europe; Fenfluramine; France;

2011
Valvular heart disease associated with benfluorex therapy: results from the French multicentre registry.
    European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 2011, Volume: 12, Issue:4

    Topics: Appetite Depressants; Body Mass Index; Comorbidity; Dose-Response Relationship, Drug; Echocardiograp

2011
Mediator scandal rocks French medical community.
    Lancet (London, England), 2011, Mar-12, Volume: 377, Issue:9769

    Topics: Appetite Depressants; Drug Industry; Fenfluramine; France; Heart Valve Diseases; Humans; Hypolipidem

2011
[What were the indications for the Mediator in 1979?].
    Revue medicale suisse, 2011, Feb-09, Volume: 7, Issue:281

    Topics: Anxiety; Appetite Depressants; Diabetes Mellitus, Type 2; Fenfluramine; France; Heart Valve Diseases

2011
Benfluorex: how many deaths?
    Prescrire international, 2011, Volume: 20, Issue:113

    Topics: Appetite Depressants; Familial Primary Pulmonary Hypertension; Fenfluramine; France; Heart Valve Dis

2011
Mitral and aortic valvular disease associated with benfluorex use.
    The Journal of heart valve disease, 2011, Volume: 20, Issue:3

    Topics: Aortic Valve; Appetite Depressants; Fatal Outcome; Female; Fenfluramine; Heart Valve Diseases; Human

2011
[The French are wary of their drugs].
    Revue medicale suisse, 2011, May-25, Volume: 7, Issue:296

    Topics: Appetite Depressants; Body Mass Index; Cause of Death; Drugs, Generic; Fenfluramine; France; Heart V

2011
Valvular heart disease associated with benfluorex therapy: high prevalence in patients with unexplained restrictive valvular heart disease.
    European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 2011, Volume: 12, Issue:9

    Topics: Aortic Valve; Appetite Depressants; Echocardiography, Doppler; Female; Fenfluramine; Heart Valve Dis

2011
Estimate of deaths due to valvular insufficiency attributable to the use of benfluorex in France.
    Pharmacoepidemiology and drug safety, 2012, Volume: 21, Issue:4

    Topics: Adult; Aged; Appetite Depressants; Cohort Studies; Databases, Factual; Female; Fenfluramine; France;

2012
Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy.
    Fundamental & clinical pharmacology, 2012, Volume: 26, Issue:2

    Topics: Adult; Aortic Valve; Bioprosthesis; Cicatrix, Hypertrophic; Female; Fenfluramine; Fibrosis; Heart Va

2012
Appetite suppressant was probably responsible for 1300 deaths, study shows.
    BMJ (Clinical research ed.), 2012, Feb-09, Volume: 344

    Topics: Appetite Depressants; Drug Industry; Drug-Related Side Effects and Adverse Reactions; Fenfluramine;

2012
European legislators tighten rules on drug safety.
    BMJ (Clinical research ed.), 2012, Sep-18, Volume: 345

    Topics: Adverse Drug Reaction Reporting Systems; Appetite Depressants; Diabetes Mellitus, Type 2; Europe; Fe

2012
[Valvular heart disease associated with benfluorex].
    Revista espanola de cardiologia, 2003, Volume: 56, Issue:2

    Topics: Appetite Depressants; Female; Fenfluramine; Fibrosis; Heart Valve Diseases; Heart Valve Prosthesis I

2003