benfluorex has been researched along with Heart Valve Diseases in 31 studies
Heart Valve Diseases: Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors describe the case of a simultaneous mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy in a 40-year-old woman." | 7.78 | Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy. ( Ayme-Dietrich, E; Bischoff, N; Dallemand, R; Gasser, B; Lawson, R; Monassier, L, 2012) |
| "Benfluorex is a fenfluramine derivative which has been marketed between 1976 and 2009." | 5.46 | Fatal postoperative systemic pulmonary hypertension in benfluorex-induced valvular heart disease surgery: A case report. ( Banfi, C; Baufreton, C; Bruneval, P; Ennezat, PV; Fouquet, O; Giraud, R; Rousselet, MC, 2017) |
| "Adjusted RR for mitral insufficiency and aortic insufficiency admissions were 2." | 5.36 | Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus. ( Allemand, H; Fagot, JP; Montastruc, JL; Neumann, A; Païta, M; Ricordeau, P; Simon, D; Tuppin, P; Weill, A, 2010) |
| "The authors describe the case of a simultaneous mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy in a 40-year-old woman." | 3.78 | Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy. ( Ayme-Dietrich, E; Bischoff, N; Dallemand, R; Gasser, B; Lawson, R; Monassier, L, 2012) |
| " As a derivative of fenfluramine with an appetite suppressant action, benfluorex is preferentially used in overweight patients." | 3.75 | Fenfluramine-like cardiovascular side-effects of benfluorex. ( Boutet, K; Carlhant-Kowalski, D; Frachon, I; Gut-Gobert, C; Humbert, M; Jobic, Y; Leroyer, C; Simonneau, G; Sitbon, O, 2009) |
| " Further studies should be conducted to determine the subsequent course of benfluorex-induced VHD and PAH, and to identify genetic, biological and clinical factors that determine individual susceptibility to developing such adverse effects." | 2.50 | Adverse effects of benfluorex on heart valves and pulmonary circulation. ( Andréjak, M; Maréchaux, S; Peltier, M; Szymanski, C; Tribouilloy, C, 2014) |
| "Benfluorex is a fenfluramine derivative which has been marketed between 1976 and 2009." | 1.46 | Fatal postoperative systemic pulmonary hypertension in benfluorex-induced valvular heart disease surgery: A case report. ( Banfi, C; Baufreton, C; Bruneval, P; Ennezat, PV; Fouquet, O; Giraud, R; Rousselet, MC, 2017) |
| "Benfluorex is a fenfluramine derivative approved for the treatment of metabolic syndrome and type 2 diabetes mellitus." | 1.37 | Mitral and aortic valvular disease associated with benfluorex use. ( Castellant, P; Etienne, Y; Fatemi, M; Frachon, I; Jobic, Y; Quintin-Roué, I, 2011) |
| "Benfluorex is an amphetamine appetite suppressant derived from fenfluramine." | 1.36 | Benfluorex: increasing reports of valve disorders. ( , 2010) |
| "Adjusted RR for mitral insufficiency and aortic insufficiency admissions were 2." | 1.36 | Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus. ( Allemand, H; Fagot, JP; Montastruc, JL; Neumann, A; Païta, M; Ricordeau, P; Simon, D; Tuppin, P; Weill, A, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (9.68) | 29.6817 |
| 2010's | 28 (90.32) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dyer, O | 1 |
| Szymanski, C | 2 |
| Andréjak, M | 1 |
| Peltier, M | 1 |
| Maréchaux, S | 3 |
| Tribouilloy, C | 3 |
| Rusinaru, D | 1 |
| Jobic, Y | 7 |
| Ederhy, S | 1 |
| Donal, E | 1 |
| Réant, P | 1 |
| Arnalsteen, E | 1 |
| Boulanger, J | 1 |
| Garban, T | 1 |
| Ennezat, PV | 3 |
| Jeu, A | 1 |
| Plurien, F | 1 |
| Bruneval, P | 2 |
| Iung, B | 1 |
| Le Ven, F | 2 |
| Alavi, Z | 1 |
| Etienne, Y | 4 |
| Didier, R | 1 |
| Porcher, R | 1 |
| Baufreton, C | 1 |
| Rousselet, MC | 1 |
| Fouquet, O | 1 |
| Giraud, R | 1 |
| Banfi, C | 1 |
| Boutet, K | 1 |
| Frachon, I | 3 |
| Gut-Gobert, C | 1 |
| Leroyer, C | 2 |
| Carlhant-Kowalski, D | 1 |
| Sitbon, O | 1 |
| Simonneau, G | 1 |
| Humbert, M | 2 |
| Le Gal, G | 1 |
| Gueffet, JP | 2 |
| Piriou, N | 1 |
| Trochu, JN | 1 |
| Weill, A | 1 |
| Païta, M | 1 |
| Tuppin, P | 1 |
| Fagot, JP | 1 |
| Neumann, A | 1 |
| Simon, D | 1 |
| Ricordeau, P | 1 |
| Montastruc, JL | 1 |
| Allemand, H | 1 |
| Droogmans, S | 1 |
| Cosyns, B | 1 |
| Van Camp, G | 1 |
| Habib, G | 2 |
| Eicher, JC | 1 |
| Blanchard-Lemoine, B | 1 |
| Rousseau, J | 1 |
| Hénon, P | 1 |
| Mullard, A | 1 |
| Nau, JY | 2 |
| Fatemi, M | 1 |
| Castellant, P | 1 |
| Quintin-Roué, I | 1 |
| Boudes, A | 1 |
| Lavoute, C | 1 |
| Avierinos, JF | 1 |
| Le Dolley, Y | 1 |
| Villacampa, C | 1 |
| Salem, A | 1 |
| Loundou, AD | 1 |
| Michel, N | 1 |
| Renard, S | 1 |
| Fournier, A | 1 |
| Zureik, M | 1 |
| Ayme-Dietrich, E | 1 |
| Lawson, R | 1 |
| Gasser, B | 1 |
| Dallemand, R | 1 |
| Bischoff, N | 1 |
| Monassier, L | 1 |
| Benkimoun, P | 1 |
| Derumeaux, G | 1 |
| Ernande, L | 1 |
| Serusclat, A | 1 |
| Servan, E | 1 |
| Bruckert, E | 1 |
| Rousset, H | 1 |
| Senn, S | 1 |
| Van Gaal, L | 1 |
| Picandet, B | 1 |
| Gavini, F | 1 |
| Moulin, P | 1 |
| Watson, R | 1 |
| Rafel Ribera, J | 1 |
| Casañas Muñoz, R | 1 |
| Anguera Ferrando, N | 1 |
| Batalla Sahún, N | 1 |
| Castro Cels, A | 1 |
| Pujadas Capmany, R | 1 |
1 review available for benfluorex and Heart Valve Diseases
| Article | Year |
|---|---|
Adverse effects of benfluorex on heart valves and pulmonary circulation.
Topics: Echocardiography; Fenfluramine; Heart Valve Diseases; Heart Valves; Humans; Hypertension, Pulmonary; | 2014 |
1 trial available for benfluorex and Heart Valve Diseases
| Article | Year |
|---|---|
Echocardiographic evidence for valvular toxicity of benfluorex: a double-blind randomised trial in patients with type 2 diabetes mellitus.
Topics: Aged; Diabetes Mellitus, Type 2; Echocardiography; Female; Fenfluramine; Glycated Hemoglobin; Heart | 2012 |
29 other studies available for benfluorex and Heart Valve Diseases
| Article | Year |
|---|---|
France to prosecute its drug regulator and Servier in scandal over diabetes drug.
Topics: Drug and Narcotic Control; Drug Industry; Fenfluramine; France; Fraud; Heart Valve Diseases; Homicid | 2017 |
Benfluorex and cardiac valve disease: long delay in publication.
Topics: Access to Information; Appetite Depressants; Fenfluramine; Heart Valve Diseases; Heart Valves; Human | 2013 |
Exposure to benfluorex: left heart valve disease very common.
Topics: Echocardiography; Fenfluramine; France; Heart Valve Diseases; Humans; Hypolipidemic Agents; Safety-B | 2013 |
Identifying drug-related disorders: a probabilistic approach.
Topics: Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Probability | 2013 |
Benfluorex: left heart valve disease very common.
Topics: Appetite Depressants; Echocardiography; Fenfluramine; France; Heart Valve Diseases; Humans | 2014 |
Food and Drug Administration criteria for the diagnosis of drug-induced valvular heart disease in patients previously exposed to benfluorex: a prospective multicentre study.
Topics: Aged; Appetite Depressants; Case-Control Studies; Echocardiography, Doppler; Female; Fenfluramine; H | 2015 |
Calcifications in benfluorex-induced valve heart disease: a misknown association.
Topics: Aged; Aortic Valve Insufficiency; Appetite Depressants; Calcinosis; Fenfluramine; Heart Valve Diseas | 2015 |
Drug-Induced- or Rheumatic- Valvular Heart Disease in Patients Exposed to Benfluorex?
Topics: Aged; Appetite Depressants; Female; Fenfluramine; France; Heart Valve Diseases; Humans; Male; Markov | 2016 |
Fatal postoperative systemic pulmonary hypertension in benfluorex-induced valvular heart disease surgery: A case report.
Topics: Appetite Depressants; Fatal Outcome; Female; Fenfluramine; Heart Valve Diseases; Heart Valve Prosthe | 2017 |
Fenfluramine-like cardiovascular side-effects of benfluorex.
Topics: Appetite Depressants; Cardiovascular Diseases; Diabetes Mellitus; Female; Fenfluramine; Heart Valve | 2009 |
Benfluorex: negative data in France, but still on the market. Neuropsychiatric disorders, pulmonary hypertension and heart valve damage.
Topics: Appetite Depressants; Fenfluramine; France; Heart Valve Diseases; Humans; Hypertension, Pulmonary; N | 2009 |
Benfluorex and unexplained valvular heart disease: a case-control study.
Topics: Aged; Case-Control Studies; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypolipidemic Agents | 2010 |
Benfluorex: increasing reports of valve disorders.
Topics: Appetite Depressants; Fenfluramine; France; Heart Valve Diseases; Humans; Hypertension, Pulmonary; P | 2010 |
Valvular heart disease associated with benfluorex.
Topics: Appetite Depressants; Diuretics; Echocardiography, Doppler, Color; Female; Fenfluramine; Furosemide; | 2010 |
Benfluorex: yet more valve disorders.
Topics: Fenfluramine; Heart Valve Diseases; Humans; Hypolipidemic Agents | 2010 |
Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus.
Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Cohort Studies; Databases, Factual; D | 2010 |
Benfluorex: the last chapter of drug-induced valvular heart disease?
Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Appetite Depressants; Europe; Fenfluramine; France; | 2011 |
Valvular heart disease associated with benfluorex therapy: results from the French multicentre registry.
Topics: Appetite Depressants; Body Mass Index; Comorbidity; Dose-Response Relationship, Drug; Echocardiograp | 2011 |
Mediator scandal rocks French medical community.
Topics: Appetite Depressants; Drug Industry; Fenfluramine; France; Heart Valve Diseases; Humans; Hypolipidem | 2011 |
[What were the indications for the Mediator in 1979?].
Topics: Anxiety; Appetite Depressants; Diabetes Mellitus, Type 2; Fenfluramine; France; Heart Valve Diseases | 2011 |
Benfluorex: how many deaths?
Topics: Appetite Depressants; Familial Primary Pulmonary Hypertension; Fenfluramine; France; Heart Valve Dis | 2011 |
Mitral and aortic valvular disease associated with benfluorex use.
Topics: Aortic Valve; Appetite Depressants; Fatal Outcome; Female; Fenfluramine; Heart Valve Diseases; Human | 2011 |
[The French are wary of their drugs].
Topics: Appetite Depressants; Body Mass Index; Cause of Death; Drugs, Generic; Fenfluramine; France; Heart V | 2011 |
Valvular heart disease associated with benfluorex therapy: high prevalence in patients with unexplained restrictive valvular heart disease.
Topics: Aortic Valve; Appetite Depressants; Echocardiography, Doppler; Female; Fenfluramine; Heart Valve Dis | 2011 |
Estimate of deaths due to valvular insufficiency attributable to the use of benfluorex in France.
Topics: Adult; Aged; Appetite Depressants; Cohort Studies; Databases, Factual; Female; Fenfluramine; France; | 2012 |
Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy.
Topics: Adult; Aortic Valve; Bioprosthesis; Cicatrix, Hypertrophic; Female; Fenfluramine; Fibrosis; Heart Va | 2012 |
Appetite suppressant was probably responsible for 1300 deaths, study shows.
Topics: Appetite Depressants; Drug Industry; Drug-Related Side Effects and Adverse Reactions; Fenfluramine; | 2012 |
European legislators tighten rules on drug safety.
Topics: Adverse Drug Reaction Reporting Systems; Appetite Depressants; Diabetes Mellitus, Type 2; Europe; Fe | 2012 |
[Valvular heart disease associated with benfluorex].
Topics: Appetite Depressants; Female; Fenfluramine; Fibrosis; Heart Valve Diseases; Heart Valve Prosthesis I | 2003 |