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benfluorex and Diabetes Mellitus

benfluorex has been researched along with Diabetes Mellitus in 10 studies

Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.

Research Excerpts

ExcerptRelevanceReference
"3 ng/mL, means +/- SE), the clinical and metabolic effects of benfluorex (B), a lipid-lowering drug able to improve insulin sensitivity."9.08Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo. ( Camisasca, R; Cassisa, C; Pacchioni, M; Piatti, PM; Pontiroli, AE; Pozza, G, 1996)
"To evaluate the change in lipids and insulin sensitivity in 10 obese type II diabetic patients after treatment with benfluorex or placebo for 2 wk."9.07Effects of benfluorex on insulin resistance and lipid metabolism in obese type II diabetic patients. ( Bianchi, R; Bongers, V; Bravenboer, B; Erkelens, DW, 1993)
"Benfluorex was withdrawn from European markets in June 2010 after reports of an association with heart valve lesions."5.38Increased risk of left heart valve regurgitation associated with benfluorex use in patients with diabetes mellitus: a multicenter study. ( Arnalsteen, E; Boulanger, J; Donal, E; Ederhy, S; Ennezat, PV; Garban, T; Jeu, A; Jobic, Y; Maréchaux, S; Réant, P; Rusinaru, D; Tribouilloy, C, 2012)
"Adjusted RR for mitral insufficiency and aortic insufficiency admissions were 2."5.36Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus. ( Allemand, H; Fagot, JP; Montastruc, JL; Neumann, A; Païta, M; Ricordeau, P; Simon, D; Tuppin, P; Weill, A, 2010)
"3 ng/mL, means +/- SE), the clinical and metabolic effects of benfluorex (B), a lipid-lowering drug able to improve insulin sensitivity."5.08Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo. ( Camisasca, R; Cassisa, C; Pacchioni, M; Piatti, PM; Pontiroli, AE; Pozza, G, 1996)
"To evaluate the change in lipids and insulin sensitivity in 10 obese type II diabetic patients after treatment with benfluorex or placebo for 2 wk."5.07Effects of benfluorex on insulin resistance and lipid metabolism in obese type II diabetic patients. ( Bianchi, R; Bongers, V; Bravenboer, B; Erkelens, DW, 1993)
" As a derivative of fenfluramine with an appetite suppressant action, benfluorex is preferentially used in overweight patients."3.75Fenfluramine-like cardiovascular side-effects of benfluorex. ( Boutet, K; Carlhant-Kowalski, D; Frachon, I; Gut-Gobert, C; Humbert, M; Jobic, Y; Leroyer, C; Simonneau, G; Sitbon, O, 2009)
"Benfluorex + insulin is a valid alternative for obese patients who remain poorly controlled despite insulin or who require high doses of insulin."2.69Added benfluorex in obese insulin-requiring type 2 diabetes. ( Bauduceau, B; Brun, JM; Guillon-Metz, F; Leutenegger, M; Martin, C; Nicolino-Peltier, C; Richard, JL; Vannereau, D, 1998)
"Benfluorex hydrochloride has known lipid- and glucose-lowering effects."2.67Benfluorex decreases insulin resistance and improves lipid profiles in obese type 2 diabetic patients. ( Bianchi, R; Bongers, V; Bravenboer, B; Erkelens, DW, 1993)
"Benfluorex was withdrawn from European markets in June 2010 after reports of an association with heart valve lesions."1.38Increased risk of left heart valve regurgitation associated with benfluorex use in patients with diabetes mellitus: a multicenter study. ( Arnalsteen, E; Boulanger, J; Donal, E; Ederhy, S; Ennezat, PV; Garban, T; Jeu, A; Jobic, Y; Maréchaux, S; Réant, P; Rusinaru, D; Tribouilloy, C, 2012)
"Adjusted RR for mitral insufficiency and aortic insufficiency admissions were 2."1.36Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus. ( Allemand, H; Fagot, JP; Montastruc, JL; Neumann, A; Païta, M; Ricordeau, P; Simon, D; Tuppin, P; Weill, A, 2010)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (50.00)18.2507
2000's1 (10.00)29.6817
2010's4 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tribouilloy, C3
Maréchaux, S2
Jobic, Y3
Jeu, A2
Ederhy, S2
Donal, E2
Réant, P2
Arnalsteen, E2
Boulanger, J2
Garban, T2
Ennezat, PV2
Andréjak, M2
Rusinaru, D3
Boutet, K1
Frachon, I1
Gut-Gobert, C1
Leroyer, C1
Carlhant-Kowalski, D1
Sitbon, O1
Simonneau, G1
Humbert, M1
Henon, P1
Tribouilloy, L1
Leleu, F1
Sevestre, H1
Peltier, M1
Caus, T1
Weill, A1
Païta, M1
Tuppin, P1
Fagot, JP1
Neumann, A1
Simon, D1
Ricordeau, P1
Montastruc, JL1
Allemand, H1
Bianchi, R2
Bongers, V2
Bravenboer, B2
Erkelens, DW2
Brindley, DN1
Pontiroli, AE1
Pacchioni, M1
Piatti, PM1
Cassisa, C1
Camisasca, R1
Pozza, G1
Leutenegger, M1
Bauduceau, B1
Brun, JM1
Guillon-Metz, F1
Martin, C1
Nicolino-Peltier, C1
Richard, JL1
Vannereau, D1

Reviews

1 review available for benfluorex and Diabetes Mellitus

ArticleYear
Mechanisms for the effects of benfluorex on the obese-diabetic-dyslipidemic syndrome.
    Diabetes/metabolism reviews, 1993, Volume: 9 Suppl 1

    Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fenfluramine; Humans; Hyperlipidemias; Hypogl

1993

Trials

4 trials available for benfluorex and Diabetes Mellitus

ArticleYear
Benfluorex decreases insulin resistance and improves lipid profiles in obese type 2 diabetic patients.
    Diabetes/metabolism reviews, 1993, Volume: 9 Suppl 1

    Topics: Adult; Blood Glucose; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind Method;

1993
Effects of benfluorex on insulin resistance and lipid metabolism in obese type II diabetic patients.
    Diabetes care, 1993, Volume: 16, Issue:4

    Topics: Apolipoprotein A-I; Apolipoproteins B; Appetite Depressants; Blood Glucose; C-Peptide; Cholesterol;

1993
Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo.
    The Journal of clinical endocrinology and metabolism, 1996, Volume: 81, Issue:10

    Topics: 3-Hydroxybutyric Acid; Appetite Depressants; Body Weight; C-Peptide; Diabetes Mellitus; Diabetes Mel

1996
Added benfluorex in obese insulin-requiring type 2 diabetes.
    Diabetes & metabolism, 1998, Volume: 24, Issue:1

    Topics: Adolescent; Adult; Aged; Blood Glucose; Body Weight; C-Peptide; Diabetes Mellitus; Diabetes Mellitus

1998

Other Studies

5 other studies available for benfluorex and Diabetes Mellitus

ArticleYear
Frequency of drug-induced valvular heart disease in patients previously exposd to benfluorex: a multicentre prospective study.
    European heart journal, 2013, Volume: 34, Issue:46

    Topics: Analysis of Variance; Aortic Valve Insufficiency; Appetite Depressants; Case-Control Studies; Diabet

2013
Fenfluramine-like cardiovascular side-effects of benfluorex.
    The European respiratory journal, 2009, Volume: 33, Issue:3

    Topics: Appetite Depressants; Cardiovascular Diseases; Diabetes Mellitus; Female; Fenfluramine; Heart Valve

2009
Restrictive organic mitral regurgitation associated with benfluorex therapy.
    European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 2010, Volume: 11, Issue:7

    Topics: Aged; Appetite Depressants; Body Mass Index; Cardiomyopathy, Restrictive; Diabetes Mellitus; Drug Th

2010
Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus.
    Pharmacoepidemiology and drug safety, 2010, Volume: 19, Issue:12

    Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Cohort Studies; Databases, Factual; D

2010
Increased risk of left heart valve regurgitation associated with benfluorex use in patients with diabetes mellitus: a multicenter study.
    Circulation, 2012, Dec-11, Volume: 126, Issue:24

    Topics: Aged; Aortic Valve Insufficiency; Appetite Depressants; Diabetes Mellitus; Echocardiography; Europe;

2012