benfluorex has been researched along with Diabetes Mellitus, Adult-Onset in 27 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "3 ng/mL, means +/- SE), the clinical and metabolic effects of benfluorex (B), a lipid-lowering drug able to improve insulin sensitivity." | 9.08 | Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo. ( Camisasca, R; Cassisa, C; Pacchioni, M; Piatti, PM; Pontiroli, AE; Pozza, G, 1996) |
| "To evaluate the change in lipids and insulin sensitivity in 10 obese type II diabetic patients after treatment with benfluorex or placebo for 2 wk." | 9.07 | Effects of benfluorex on insulin resistance and lipid metabolism in obese type II diabetic patients. ( Bianchi, R; Bongers, V; Bravenboer, B; Erkelens, DW, 1993) |
| "We have examined the effect of chronic (20 days) oral administration of benfluorex (35 mg/kg) in a rat model of NIDDM, induced by injection of STZ 5 days after birth and characterized by frank hyperglycemia, hypoinsulinemia, and hepatic and peripheral insulin resistance." | 7.68 | Benfluorex normalizes hyperglycemia and reverses hepatic insulin resistance in STZ-induced diabetic rats. ( Bailbe, D; Blondel, O; Portha, B; Serradas, P, 1993) |
| "3 ng/mL, means +/- SE), the clinical and metabolic effects of benfluorex (B), a lipid-lowering drug able to improve insulin sensitivity." | 5.08 | Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo. ( Camisasca, R; Cassisa, C; Pacchioni, M; Piatti, PM; Pontiroli, AE; Pozza, G, 1996) |
| "To evaluate the change in lipids and insulin sensitivity in 10 obese type II diabetic patients after treatment with benfluorex or placebo for 2 wk." | 5.07 | Effects of benfluorex on insulin resistance and lipid metabolism in obese type II diabetic patients. ( Bianchi, R; Bongers, V; Bravenboer, B; Erkelens, DW, 1993) |
| " Benfluorex treatment improves insulin sensitivity and has antihyperglycemic and hypolipidemic effects in human beings and in experimental animals." | 4.78 | [Mode of action of benfluorex. Recent data]. ( Brindley, DN, 1992) |
| "We have examined the effect of chronic (20 days) oral administration of benfluorex (35 mg/kg) in a rat model of NIDDM, induced by injection of STZ 5 days after birth and characterized by frank hyperglycemia, hypoinsulinemia, and hepatic and peripheral insulin resistance." | 3.68 | Benfluorex normalizes hyperglycemia and reverses hepatic insulin resistance in STZ-induced diabetic rats. ( Bailbe, D; Blondel, O; Portha, B; Serradas, P, 1993) |
| "Treatment with benfluorex was well tolerated; 39% of these patients reported one or more emergent adverse events (compared to 38% on placebo and 43% on metformin) and only two patients suffered a treatment-related, serious adverse event." | 2.71 | Six-month efficacy of benfluorex vs. placebo or metformin in diet-failed type 2 diabetic patients. ( Del Prato, S; Erkelens, DW; Leutenegger, M, 2003) |
| "Benfluorex + insulin is a valid alternative for obese patients who remain poorly controlled despite insulin or who require high doses of insulin." | 2.69 | Added benfluorex in obese insulin-requiring type 2 diabetes. ( Bauduceau, B; Brun, JM; Guillon-Metz, F; Leutenegger, M; Martin, C; Nicolino-Peltier, C; Richard, JL; Vannereau, D, 1998) |
| "Benfluorex is a hypolipidaemic agent with biguanide-like properties." | 2.67 | Mechanism(s) of the blood glucose lowering action of benfluorex. ( Da Tos, V; De Biasi, L; Del Prato, S; Dorella, M; Marescotti, MC; Riccio, A; Tiengo, A; Vigili de Kreutzenberg, S, 1993) |
| "Benfluorex hydrochloride has known lipid- and glucose-lowering effects." | 2.67 | Benfluorex decreases insulin resistance and improves lipid profiles in obese type 2 diabetic patients. ( Bianchi, R; Bongers, V; Bravenboer, B; Erkelens, DW, 1993) |
| "Benfluorex is a hypolipidemic agent with biguanide-like properties." | 2.67 | [Mechanisms of hypoglycemic action of benfluorex]. ( Da Tos, V; Del Prato, S; Dorella, M; Riccio, A; Vigili de Kreutzenberg, S, 1992) |
| "Benfluorex has been reported to decrease blood glucose in different dismetabolic conditions, particularly in noninsulin-dependent diabetic (NIDD) patients, but the mechanism of this effect is poorly known." | 2.67 | Benfluorex and blood glucose control in non insulin-dependent diabetic patients. ( Boine, L; Cavallo-Perin, P; Cobelli, C; Estivi, P; Galletti, R; Pacini, G; Pagano, G, 1991) |
| "The relief of insulin resistance is one of the two therapeutic targets of the treatment of type 2 diabetes." | 2.40 | [Current status of the treatment of type 2 diabetes mellitus. The revival of insulin-resistance drugs]. ( Andres, E; Blicklé, JF; Brogard, JM; Neyrolles, N, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (66.67) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 5 (18.52) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Göldner, V | 1 |
| Karst, U | 1 |
| Moulin, P | 3 |
| André, M | 2 |
| Alawi, H | 2 |
| Dos Santos, LC | 2 |
| Khalid, AK | 2 |
| Koev, D | 2 |
| Moore, R | 2 |
| Serban, V | 2 |
| Picandet, B | 3 |
| Francillard, M | 2 |
| Benkimoun, P | 1 |
| Nau, JY | 1 |
| Vincent, L | 1 |
| Guardiola, B | 1 |
| Tsouderos, Y | 1 |
| Canet, E | 1 |
| Derumeaux, G | 1 |
| Ernande, L | 1 |
| Serusclat, A | 1 |
| Servan, E | 1 |
| Bruckert, E | 1 |
| Rousset, H | 1 |
| Senn, S | 1 |
| Van Gaal, L | 1 |
| Gavini, F | 1 |
| Watson, R | 1 |
| Del Prato, S | 3 |
| Erkelens, DW | 3 |
| Leutenegger, M | 2 |
| Riccio, A | 2 |
| Vigili de Kreutzenberg, S | 2 |
| Dorella, M | 2 |
| Da Tos, V | 2 |
| De Biasi, L | 1 |
| Marescotti, MC | 1 |
| Tiengo, A | 1 |
| De Feo, P | 1 |
| Lavielle, R | 1 |
| De Gregoris, P | 1 |
| Bolli, GB | 1 |
| Bianchi, R | 2 |
| Bongers, V | 2 |
| Bravenboer, B | 2 |
| Brindley, DN | 2 |
| Portha, B | 2 |
| Serradas, P | 2 |
| Bailbé, D | 2 |
| Blondel, O | 2 |
| Picarel, F | 1 |
| Storlien, LH | 1 |
| Pan, DA | 1 |
| Kusunoki, M | 1 |
| Cooney, GJ | 1 |
| Pontiroli, AE | 1 |
| Pacchioni, M | 1 |
| Piatti, PM | 1 |
| Cassisa, C | 1 |
| Camisasca, R | 1 |
| Pozza, G | 1 |
| Ravel, D | 1 |
| Bauduceau, B | 1 |
| Brun, JM | 2 |
| Guillon-Metz, F | 1 |
| Martin, C | 1 |
| Nicolino-Peltier, C | 1 |
| Richard, JL | 1 |
| Vannereau, D | 1 |
| Drain, P | 1 |
| Brogard, JM | 1 |
| Neyrolles, N | 1 |
| Andres, E | 1 |
| Blicklé, JF | 1 |
| Cavallo-Perin, P | 1 |
| Estivi, P | 1 |
| Boine, L | 1 |
| Galletti, R | 1 |
| Pacini, G | 1 |
| Cobelli, C | 1 |
| Pagano, G | 1 |
6 reviews available for benfluorex and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Mechanisms for the effects of benfluorex on the obese-diabetic-dyslipidemic syndrome.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fenfluramine; Humans; Hyperlipidemias; Hypogl | 1993 |
Effects of benfluorex on in vivo patterns of insulin resistance induced by diets rich in fat or fructose.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Diet, Diabetic; Dietary Carbohydrates; Dietary Fa | 1993 |
[Benfluorex (Mediator) and non-insulin-dependent diabetes].
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Fenfluramine; Humans; Hypolipidemic Agents; Insul | 1997 |
[Benfluorex (Mediator): non-insulin-dependent diabetes and hypertriglyceridemia].
Topics: Diabetes Mellitus, Type 2; Fenfluramine; Humans; Hypertriglyceridemia | 1998 |
[Current status of the treatment of type 2 diabetes mellitus. The revival of insulin-resistance drugs].
Topics: Administration, Oral; Chromans; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Exercise; Fenfluramine | 1999 |
[Mode of action of benfluorex. Recent data].
Topics: Animals; Arteriosclerosis; Diabetes Mellitus, Type 2; Drug Interactions; Fatty Acids; Female; Fenflu | 1992 |
13 trials available for benfluorex and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Efficacy of benfluorex in combination with sulfonylurea in type 2 diabetic patients: an 18 to 34-week, open-label, extension period.
Topics: Adolescent; Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Fenf | 2009 |
Echocardiographic evidence for valvular toxicity of benfluorex: a double-blind randomised trial in patients with type 2 diabetes mellitus.
Topics: Aged; Diabetes Mellitus, Type 2; Echocardiography; Female; Fenfluramine; Glycated Hemoglobin; Heart | 2012 |
Six-month efficacy of benfluorex vs. placebo or metformin in diet-failed type 2 diabetic patients.
Topics: Appetite Depressants; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Fasting; Female | 2003 |
Efficacy of benfluorex in combination with sulfonylurea in type 2 diabetic patients: an 18-week, randomized, double-blind study.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Fema | 2006 |
Mechanism(s) of the blood glucose lowering action of benfluorex.
Topics: Appetite Depressants; Blood Glucose; Cholesterol; Diabetes Mellitus, Type 2; Diet, Diabetic; Female; | 1993 |
Anti-hyperglycaemic mechanisms of benfluorex in type II diabetes mellitus.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Fatty Acids, Nonesterified; Fenfluram | 1993 |
Benfluorex decreases insulin resistance and improves lipid profiles in obese type 2 diabetic patients.
Topics: Adult; Blood Glucose; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind Method; | 1993 |
Effects of benfluorex on insulin resistance and lipid metabolism in obese type II diabetic patients.
Topics: Apolipoprotein A-I; Apolipoproteins B; Appetite Depressants; Blood Glucose; C-Peptide; Cholesterol; | 1993 |
Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo.
Topics: 3-Hydroxybutyric Acid; Appetite Depressants; Body Weight; C-Peptide; Diabetes Mellitus; Diabetes Mel | 1996 |
Added benfluorex in obese insulin-requiring type 2 diabetes.
Topics: Adolescent; Adult; Aged; Blood Glucose; Body Weight; C-Peptide; Diabetes Mellitus; Diabetes Mellitus | 1998 |
[Mechanisms of hypoglycemic action of benfluorex].
Topics: Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Female; Fenfluramine; Fructosamine; Glycated He | 1992 |
[Antidiabetic efficacy of benfluorex. Clinical data].
Topics: Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Female; Fenfluramine; Humans; Hypolipidemic A | 1992 |
Benfluorex and blood glucose control in non insulin-dependent diabetic patients.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Fenfluramine; Humans; Hypolip | 1991 |
8 other studies available for benfluorex and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Benfluorex metabolism complemented by electrochemistry-mass spectrometry.
Topics: Diabetes Mellitus, Type 2; Electrochemistry; Fenfluramine; Humans; Norfenfluramine; Tandem Mass Spec | 2023 |
French doctors demand to know why drug stayed on the market for so long.
Topics: Attitude of Health Personnel; Diabetes Mellitus, Type 2; Fenfluramine; France; Humans; Hypoglycemic | 2010 |
[What were the indications for the Mediator in 1979?].
Topics: Anxiety; Appetite Depressants; Diabetes Mellitus, Type 2; Fenfluramine; France; Heart Valve Diseases | 2011 |
Mediator: who's to blame?
Topics: Appetite Depressants; Diabetes Mellitus, Type 2; Drug Industry; Fenfluramine; France; Glycated Hemog | 2011 |
European legislators tighten rules on drug safety.
Topics: Adverse Drug Reaction Reporting Systems; Appetite Depressants; Diabetes Mellitus, Type 2; Europe; Fe | 2012 |
Insulin resistance, hyperinsulinemia and diabetes--contribution of benfluorex. Prague, 11 September 1992. Symposium proceedings.
Topics: Animals; Diabetes Mellitus, Type 2; Fenfluramine; Humans; Hyperinsulinism; Hypoglycemic Agents; Insu | 1993 |
Effect of benfluorex on insulin secretion and insulin action in streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fenfluramine; Gl | 1993 |
Benfluorex normalizes hyperglycemia and reverses hepatic insulin resistance in STZ-induced diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Female; Fenflura | 1993 |