benextramine has been researched along with Muscle Contraction in 14 studies
benextramine: RN given refers to parent cpd
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The competitive alpha1-adrenoceptor antagonists produced dextral shifts of the dose-response curves to NA in longitudinal and circular muscle." | 1.31 | Discrimination by SZL49 between contractions evoked by noradrenaline in longitudinal and circular muscle of human vas deferens. ( Amobi, NI; Guillebaud, J; Kaisary, AV; Smith, IC; Turner, E, 2002) |
| " Furthermore, NPY was without effect on the dose-response curve to ATP in resting conditions." | 1.29 | Failure of the putative neuropeptide Y antagonists, benextramine and PYX-2, to inhibit Y2 receptors in rat isolated prostatic vas deferens. ( Corsi, M; Palea, S; Ratti, E; Rimland, JM; Trist, DG, 1995) |
| "Benextramine was equipotent against the imidazoline, clonidine and the thiazoloazepine B-HT920, however, higher concentrations of benextramine were required for an equivalent non-competitive antagonism of the beta-phenethylamine, alpha-methylnoradrenaline." | 1.27 | The action and interaction of beta-phenethylamines and imidazolines on prejunctional alpha 2-adrenoceptors of guinea-pig ileum in the presence of the non-competitive antagonist benextramine. ( Mottram, DR; Thakar, Y, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (64.29) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Quaglia, W | 2 |
| Brasili, L | 5 |
| Cristalli, G | 1 |
| Giardinà, D | 2 |
| Picchio, MT | 1 |
| Melchiorre, C | 6 |
| Angeli, P | 3 |
| Brancia, E | 2 |
| Benfey, BG | 1 |
| Belleau, B | 1 |
| Coates, J | 1 |
| Weetman, DF | 1 |
| Gallucci, P | 1 |
| Mottram, DR | 1 |
| Thakar, Y | 1 |
| Amobi, NI | 2 |
| Smith, IC | 2 |
| O'Rourke, M | 1 |
| Kearns, S | 1 |
| Docherty, JR | 1 |
| Palea, S | 1 |
| Corsi, M | 1 |
| Rimland, JM | 1 |
| Trist, DG | 1 |
| Ratti, E | 1 |
| Van der Graaf, PH | 1 |
| Stam, WB | 1 |
| Saxena, PR | 1 |
| Guillebaud, J | 1 |
| Kaisary, AV | 1 |
| Turner, E | 1 |
| Cassinelli, A | 1 |
| Bond, RA | 1 |
| Charlton, KG | 1 |
| Clarke, DE | 1 |
14 other studies available for benextramine and Muscle Contraction
| Article | Year |
|---|---|
Structure-activity relationships among benextramine-related tetraamine disulfides. Chain length effect on alpha-adrenoreceptor blocking activity.
Topics: Adenosine Diphosphate; Adrenergic alpha-Antagonists; Animals; Chemical Phenomena; Chemistry; Cystami | 1988 |
Structure-activity relationships among benextramine-related tetraamine disulfides at peripheral alpha-adrenoreceptors.
Topics: Animals; Atrial Function; Biological Assay; Carbachol; Chemical Phenomena; Chemistry; Cystamine; Dis | 1985 |
Potentiation and inhibition of nicotinic effects on striated muscle by the tetramine disulfide benextramine.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Anura; Carbachol; Cystamine; Drug Synergism; I | 1980 |
Demonstration of alpha 1s-adrenoceptors after exposure of the rat anococcygeus to benextramine.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Cystamine; In Vitro Techniques; Male; Muscle Contr | 1983 |
The irreversible alpha-blocker benextramine interacts with two different thiol groups.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Calcium; Cystamine; In Vitro Techniques; Male; | 1983 |
N,N''-(dithio-2,1-ethanediyl)bis[N'-(pyrrol-2-ylmethyl)-1, 6,- hexanediamine] (pyrextramine), a new irreversible alpha 1-adrenoreceptor blocking agent of the tetramine disulfide class.
Topics: Adrenergic alpha-Antagonists; Animals; Cystamine; In Vitro Techniques; Jejunum; Male; Muscle Contrac | 1984 |
The action and interaction of beta-phenethylamines and imidazolines on prejunctional alpha 2-adrenoceptors of guinea-pig ileum in the presence of the non-competitive antagonist benextramine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Clonidine; Cystamine; El | 1984 |
Differential inhibition in the human vas deferens by phenoxybenzamine: a possible mechanism for its contraceptive action.
Topics: Adrenergic alpha-Antagonists; Calcium; Clonidine; Contraceptive Agents, Male; Cystamine; Humans; In | 1995 |
Investigation of the actions of chloroethylclonidine in rat aorta.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Aorta; Clonidine; Cystamine; Dioxanes; | 1995 |
Failure of the putative neuropeptide Y antagonists, benextramine and PYX-2, to inhibit Y2 receptors in rat isolated prostatic vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Cystamine; In Vitro Techniques; Male; | 1995 |
Benextramine acts as an irreversible noncompetitive antagonist of U46619-mediated contraction of the rat small mesenteric artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-Antagonists; An | 1996 |
Discrimination by SZL49 between contractions evoked by noradrenaline in longitudinal and circular muscle of human vas deferens.
Topics: Adrenergic alpha-Antagonists; Cystamine; Dibenzylchlorethamine; Humans; In Vitro Techniques; Male; M | 2002 |
Thiol group may be involved in the irreversible blockade of presynaptic alpha 2-adrenoreceptors by pyrextramine and benextramine in the isolated guinea pig ileum.
Topics: Adrenergic alpha-Antagonists; Animals; Cystamine; Electric Stimulation; Guinea Pigs; Ileum; In Vitro | 1986 |
Evidence for a receptor mediated action of norepinephrine distinct from alpha- and beta-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; C | 1986 |