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bendroflumethiazide and Heart Failure

bendroflumethiazide has been researched along with Heart Failure in 21 studies

Bendroflumethiazide: A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)
bendroflumethiazide : A sulfonamide consisting of 7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by a trifluoromethyl group and that at position 3 is substituted by a benzyl group.

Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"The effects of slow-release furosemide and bendroflumethiazide in the ambulatory treatment of mild to moderate congestive heart failure were compared in a controlled multicentre study using a randomized, double-blind procedure."9.05Multicentre comparison between slow-release furosemide and bendroflumethiazide in congestive heart failure. ( Pehrsson, SK, 1985)
"The additive natriuretic and diuretic effects of theophylline ethylenediamine and of bendroflumethiazide have been compared in permutation trial tests in patients with advanced congestive heart failure receiving long-term treatment with the highly potent diuretic, bumetanide."9.04Comparative natriuretic and diuretic efficacy of theophylline ethylenediamine and of bendroflumethiazide during long-term treatment with the potent diuretic bumetanide. Permutation trial tests in patients with congestive heart failure. ( Olesen, KH; Sigurd, B, 1978)
"Bendrofluazide and metolazone were equally effective in establishing a diuresis in patients with severe congestive cardiac failure resistant to loop diuretics."5.07Combination diuretic treatment in severe heart failure: a randomised controlled trial. ( Channer, KS; Lawson-Matthew, P; McLean, KA; Richardson, M, 1994)
"Eight patients with mild heart failure were treated in random order for 1 week with 2 mg bumethanide at 0800 and 1200 (treatment 1) h, 1 mg bumethanide at 0800, 1200, 1800, 2200 (treatment 2) and 5 mg bendroflumethiazide at 0800 and 1800 (treatment 3) h."5.07A comparison of three diuretic regimens in heart failure. ( Andreasen, F; Bech, OM; Bruun, P; Diamant, B; Eriksen, UH; Guul, SJ; Hartling, OJ; Hvidt, S; Kahr, O; Nielsen, LP, 1993)
"The effects of slow-release furosemide and bendroflumethiazide in the ambulatory treatment of mild to moderate congestive heart failure were compared in a controlled multicentre study using a randomized, double-blind procedure."5.05Multicentre comparison between slow-release furosemide and bendroflumethiazide in congestive heart failure. ( Pehrsson, SK, 1985)
"The additive natriuretic and diuretic effects of theophylline ethylenediamine and of bendroflumethiazide have been compared in permutation trial tests in patients with advanced congestive heart failure receiving long-term treatment with the highly potent diuretic, bumetanide."5.04Comparative natriuretic and diuretic efficacy of theophylline ethylenediamine and of bendroflumethiazide during long-term treatment with the potent diuretic bumetanide. Permutation trial tests in patients with congestive heart failure. ( Olesen, KH; Sigurd, B, 1978)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-199017 (80.95)18.7374
1990's3 (14.29)18.2507
2000's1 (4.76)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
CACCAMO, LP1
BRETTELL, HR1
SMITH, JG1
AIKAWA, JK1
CUMMINGS, DE1
GOODMAN, RM1
STEIGMANN, F1
JOHNSTON, LC1
GRIEBLE, HG1
SCHOENBERGER, JA1
FULLER, JB1
Gabriel, R1
Baylor, P1
Channer, KS2
McLean, KA1
Lawson-Matthew, P1
Richardson, M2
Andreasen, F1
Eriksen, UH1
Guul, SJ1
Nielsen, LP1
Bech, OM1
Diamant, B1
Kahr, O1
Bruun, P1
Hartling, OJ1
Hvidt, S1
Uusimaa, P1
Tokola, H1
Ruskoaho, H1
Vuolteenaho, O1
Risteli, J1
Ylitalo, A1
Peuhkurinen, K1
Sigurd, B3
Olesen, KH3
Lawson, DH1
Boddy, K1
Gray, JM1
Mahaffey, M1
Mills, E1
Wennevold, A1
Crook, R1
Jones, JV1
Bain, PG1
Egner, W1
Walker, PR1
Pehrsson, SK1
Dyckner, T1
Wester, PO1
Juul, J2
Somers, K1
Sood, NK1
Brenton, DP1
Nielsen, U1
Stewart, JH1
Edwards, KD1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy and Tolerability of Combination Intravenous Diuretic Therapy Versus Intravenous Loop Diuretic Therapy Alone for the Treatment of Acute Decompensated Heart Failure[NCT05840536]Phase 40 participants (Actual)Interventional2014-05-31Withdrawn
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

9 trials available for bendroflumethiazide and Heart Failure

ArticleYear
Comparison of the chronic effects of bendrofluazide, bumetanide and frusemide on plasma biochemical variables.
    Postgraduate medical journal, 1981, Volume: 57, Issue:664

    Topics: Aged; Analysis of Variance; Bendroflumethiazide; Blood Chemical Analysis; Bumetanide; Clinical Trial

1981
Combination diuretic treatment in severe heart failure: a randomised controlled trial.
    British heart journal, 1994, Volume: 71, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bendroflumethiazide; Body Weight; Creatinine; Diuretics;

1994
A comparison of three diuretic regimens in heart failure.
    European journal of clinical investigation, 1993, Volume: 23, Issue:4

    Topics: Aged; Aged, 80 and over; Bendroflumethiazide; Blood Volume; Bumetanide; Circadian Rhythm; Diuretics;

1993
Comparative natriuretic and diuretic efficacy of theophylline ethylenediamine and of bendroflumethiazide during long-term treatment with the potent diuretic bumetanide. Permutation trial tests in patients with congestive heart failure.
    Acta medica Scandinavica, 1978, Volume: 203, Issue:1-2

    Topics: Bendroflumethiazide; Bumetanide; Clinical Trials as Topic; Diuresis; Diuretics; Drug Evaluation; Dru

1978
The supra-additive natriuretic effect addition of bendroflumethiazide and bumetanide in congestive heart failure. Permutation trial tests in patients in long-term treatment with bumetanide.
    American heart journal, 1975, Volume: 89, Issue:2

    Topics: Adult; Bendroflumethiazide; Benzoates; Butylamines; Chlorides; Clinical Trials as Topic; Coronary Di

1975
Multicentre comparison between slow-release furosemide and bendroflumethiazide in congestive heart failure.
    European journal of clinical pharmacology, 1985, Volume: 28, Issue:3

    Topics: Adult; Aged; Bendroflumethiazide; Clinical Trials as Topic; Delayed-Action Preparations; Female; Fur

1985
[Amiloride. A clinical study of a potassium-retaining diuretic].
    Ugeskrift for laeger, 1969, Oct-16, Volume: 131, Issue:42

    Topics: Adult; Aged; Bendroflumethiazide; Bicarbonates; Clinical Trials as Topic; Diuresis; Diuretics; Femal

1969
The supra-additive natriuretic effect addition of quinethazone or bendroflumethiazide during long-term treatment with furosemide and spironolactone. Permutation trial tests in patients with congestive heart failure.
    Acta medica Scandinavica, 1971, Volume: 190, Issue:3

    Topics: Adult; Bendroflumethiazide; Clinical Trials as Topic; Diuresis; Drug Synergism; Furosemide; Heart Fa

1971
Clinical comparison of frusemide with bendrofluazide, mersalyl, and ethacrynic acid.
    British medical journal, 1965, Nov-27, Volume: 2, Issue:5473

    Topics: Adult; Aged; Bendroflumethiazide; Diuretics; Edema; Ethacrynic Acid; Female; Furosemide; Heart Failu

1965

Other Studies

12 other studies available for bendroflumethiazide and Heart Failure

ArticleYear
Benzydroflumethiazide in the treatment of edematous states: a preliminary trial.
    The West Virginia medical journal, 1962, Volume: 58

    Topics: Bendroflumethiazide; Edema; Heart Failure; Humans; Steroids

1962
S35-LABELED BENDROFLUMETHIAZIDE IN HUMAN BEINGS: CLINICAL STUDIES.
    Archives of internal medicine, 1964, Volume: 113

    Topics: Adolescent; Bendroflumethiazide; Chlorothiazide; Geriatrics; Heart Failure; Humans; Hydrochlorothiaz

1964
BENDROFLUMETHIAZIDE IN THE TREATMENT OF CARDIAC EDEMA AND HYPERTENSION.
    Journal of the American Geriatrics Society, 1964, Volume: 12

    Topics: Ascorbic Acid; Bendroflumethiazide; Diuretics; Edema, Cardiac; Electrolytes; Feeding and Eating Diso

1964
TREATMENT OF ARTERIAL HYPERTENSIVE DISEASE WITH DIURETICS. III. CHLORTHALIDONE ALONE AND IN COMBINATION WITH SPIRONOLACTONE.
    The American journal of the medical sciences, 1964, Volume: 247

    Topics: Bendroflumethiazide; Cardiomegaly; Chlorides; Chlorthalidone; Coronary Disease; Creatine; Creatinine

1964
Vasoactive peptides and procollagen propeptides in patients with hypertension in relation to cardiac hypertrophy and diastolic heart failure: design of the study and patient characteristics.
    Journal of human hypertension, 2001, Volume: 15 Suppl 1

    Topics: Amlodipine; Antihypertensive Agents; Atenolol; Atrial Natriuretic Factor; Bendroflumethiazide; Cardi

2001
Potassium supplements in patients receiving long-term diuretics for oedema.
    The Quarterly journal of medicine, 1976, Volume: 45, Issue:179

    Topics: Bendroflumethiazide; Body Composition; Bumetanide; Diuretics; Edema, Cardiac; Female; Furosemide; He

1976
Thiazides with loop diuretics for severe congestive heart failure.
    Lancet (London, England), 1990, Apr-14, Volume: 335, Issue:8694

    Topics: Aged; Bendroflumethiazide; Diuresis; Drug Administration Schedule; Drug Therapy, Combination; Female

1990
Thiazide-induced dilutional hyponatraemia masquerading as subarachnoid haemorrhage.
    Lancet (London, England), 1986, Sep-13, Volume: 2, Issue:8507

    Topics: Aged; Amiloride; Bendroflumethiazide; Diagnosis, Differential; Drug Combinations; Female; Heart Fail

1986
Renal excretion of electrolytes in patients on long-term diuretic therapy for arterial hypertension and/or congestive heart failure.
    Acta medica Scandinavica, 1985, Volume: 218, Issue:5

    Topics: Aged; Bendroflumethiazide; Diuretics; Electrolytes; Extracellular Space; Female; Furosemide; Heart F

1985
Therapeutic conferences. Heart failure--I.
    British medical journal, 1971, Mar-20, Volume: 1, Issue:5750

    Topics: Aged; Bendroflumethiazide; Diet; Digoxin; Diuretics; Female; Furosemide; Heart; Heart Failure; Human

1971
A clinical evaluation of debrisoquine sulphate.
    The British journal of clinical practice, 1968, Volume: 22, Issue:9

    Topics: Adult; Aged; Amidines; Antihypertensive Agents; Bendroflumethiazide; Digitalis Glycosides; Female; H

1968
[MK 870. A comparison of the saluretic action of MK 870, bendroflumethiazide and bendroflumethiazide + MK 870].
    Ugeskrift for laeger, 1968, Apr-18, Volume: 130, Issue:16

    Topics: Adult; Aged; Bendroflumethiazide; Chlorides; Diuretics; Electrolytes; Female; Heart Failure; Humans;

1968