benazepril and Drug-Overdose

An epiletic patient, suffering from partial complex seizures and hypertension, ingested approximately 42 g of oxcarbazepine (OXC) and an undefined number of tablets containing an association of benazepril and hydrochlorothiazide along with some glasses of wine. Four hours later he was brought to the emergency room. He was stuporous and gradually became unconscious. Therefore he was intubated and, approximately 6 hours after the overdose, transferred to the intensive care unit, where he underwent a 4-hour hemodialysis. Even if this procedure did not accelerate the elimination of the prodrug nor its active metabolite (monohydrocarbazepine), 3 hours after the end of dialysis the patient was fully recovered.

Topics: Anticonvulsants; Antihypertensive Agents; Benzazepines; Carbamazepine; Critical Care; Diuretics; Drug Overdose; Humans; Hydrochlorothiazide; Male; Middle Aged; Oxcarbazepine; Recovery of Function; Renal Dialysis; Tablets; Time Factors; Wine