bemethyl and Hypoxia

It was assessed the efficacy of drugs belonging to the class of actoprotectors and antihypoxants, which are prescribed for short-term adaptation of the human organism moving from middle altitude (1670 m) to high altitude (3750 m). Volunteers stayed at the middle altitude for 15 days before moving to the high altitude. Prior to climbing, upon arrival at high altitude, and on the 3rd day, the state of the CNS, cardiovascular system, red and white blood growth, and some indices of the energy exchange metabolism were assessed. Drugs or placebo were administered in tablets after the first testing (one hour before moving to high altitude), upon arrival at altitude (next day, after breakfast), and on the third day (one hour before last testing). It is established that a combination of metaprote and ladasten (in doses of 0.125 and 0.1 g, respectively) favors acceleration of the short-term adaptation, which is manifested by the improved tolerance of physical activity at high altitude and the acceleration of white and red blood growth. In case of the combined administration of both actoprotectors, the adaptive reactions of tolerance and blood system were more pronounced in comparison to the administration of hypoxen (0.5 g) alone. A distinguishing feature of the reaction of the human organism upon taking the combination of actoprotectors was that adaptation of the energy supply system (judging from metabolites studied) already took place in the first hours of staying at high altitudes, while the adaptation upon taking 0.5 g hypoxen was observed on the 3rd day and the adaptive reactions in placebo group were still developing on the 3rd day.

Topics: Acclimatization; Adamantane; Adult; Altitude; Antioxidants; Benzimidazoles; Blood Cell Count; Blood Pressure; Cardiovascular System; Central Nervous System; Drug Administration Schedule; Energy Metabolism; Heart Rate; Humans; Hypoxia; Male; Phenyl Ethers; Stroke Volume

In experiments on nonlinear male mice the ability of new derivatives of nitrogen-containing heterocyclic compounds to increase the physical working capacity in conditions of hyperthermia, hypothermia and acute normobaric hypoxia and hypercapnia has been investigated. It is established, that pyridine derivative IBHF-11 has more expressed positive action in the said conditions. It provided increase of the working capacity of animals at all kinds of extreme influence, and the value of positive action was comparable, and in conditions of acute normobaric hypoxia and hypercapnia exceeded those at the reference products bemitil and bromantan.

Topics: Amantadine; Animals; Antioxidants; Benzimidazoles; Drug Evaluation, Preclinical; Fever; Hypercapnia; Hypothermia; Hypoxia; Male; Mice; Physical Endurance

The rats were adapted to hypoxic hypoxia by intermittent training in a flow pressure chamber for 3 days. The course of bemithyl treatment (25 mg/kg intraperitoneally, 3 days) started immediately after the 1st day of training. Bemithyl potentiated the adaptive metabolic changes in rat brain induced by repeated hypoxic hypoxia, increased the individual resistance to hypoxia, and produced a long-lasting effect.

Topics: Altitude; Animals; Antioxidants; Benzimidazoles; Brain; Free Radicals; Glutathione; Hypoxia; Lipid Peroxidation; Male; Physical Conditioning, Animal; Rats; Respiratory Mechanics; Time Factors

Monotherapy of consequences of craniocerebral trauma with pyrazidol (1 mg/kg) produced an anxiolytic effect in animals highly resistant to hypoxia and activating effect on low resistant animals. Treatment with bemitil in a dose of 25 mg/kg produced a cerebroprotective effect and normalized individual behavioral characteristics, parameters of energy metabolism, and state of the antioxidant system in the brain of highly and low resistant rats. The effect of bemitil was most pronounced in highly resistant animals. During combined treatment, pyrazidol and bemitil had an additive effect in animals of both groups. They normalized behavioral reactions and prevented the development of metabolic disturbances in the brain.

Topics: Animals; Animals, Outbred Strains; Antioxidants; Behavior, Animal; Benzimidazoles; Carbazoles; Craniocerebral Trauma; Drug Synergism; Drug Therapy, Combination; Energy Metabolism; Hypoxia; Lipid Peroxidation; Male; Neuroprotective Agents; Rats

Intraperitoneal injection of bemithyl in a dose of 25 mg/kg for 3 days after craniocerebral injury reduced psychopathological symptoms in rats with different resistance to acute hypoxia, restored the structure of individual behavior, and prevented metabolic disorders in the brain.

Topics: Animals; Antioxidants; Benzimidazoles; Body Weight; Brain; Brain Injuries; Carbon Tetrachloride Poisoning; Craniocerebral Trauma; Disease Models, Animal; Hypoxia; Injections, Intraperitoneal; Male; Metabolic Diseases; Neuroprotective Agents; Piracetam; Rats; Temperature; Time Factors

The method of the study of medical agent influence and biological active substances on duration of small laboratory animals swimming has been worked out excluding the air. For this purpose the animals were placed into altitude chamber, filled with water by 1/3 (one-third) of its volume being in antiorthostatic position on dipping into water. It has been established that at the altitude of 4000 (four thousand) meters high the rat swimming duration became shorter in comparison with their work under normal pressure in 2.5-4 times. Bemitil stimulating work in hypobaric hypoxia depresses it sharply. Bemitil stimulating influence on the rat efficiency did not appear with rising. Antioxidant substance ionol increased efficiency in normal conditions and in hypoxia AKS-85 adaptogenic compound increased swimming in the height duration to a greater degree, mildronat substance for efficiency restoration produced actoprotective influence.

Topics: Amphetamine; Animals; Antioxidants; Atmosphere Exposure Chambers; Atmospheric Pressure; Benzimidazoles; Butylated Hydroxytoluene; Cardiovascular Agents; Hypoxia; Methylhydrazines; Mice; Physical Endurance; Posture; Swimming

The authors discovered antihypoxic properties of the bemitil (pretreatment injections 50 mg/kg intraperitoneally) in the experiments on rats with the circulatory or hypoxic hypoxia. There was limitation of pO decrease and diene conjugates and Schiff bases production increase with the drug in the circulatory hypoxia conditions. Bemitil restricted malondialdehyde accumulation in the rat brain homogenate under the activation of free radicals processes. In the mitochondrial suspension incubation similar effect of the medicine was accompanied with limitation of organelle degradation. Bemitil showed no antiradical activity.

Topics: Animals; Antioxidants; Asphyxia; Benzimidazoles; Brain; Drug Evaluation, Preclinical; Electroencephalography; Female; Hypoxia; Lipid Peroxidation; Male; Oxygen Consumption; Rats; Rats, Inbred Strains