bemethyl and Disease-Models--Animal

It was established that a new 3-hydroxypyridine (3-HP) derivative, 2-ethyl-6-methyl-3-hydroxypyridine L-aspartate (3-HP), in small doses (1 and 5 mg/kg) increased physical performance in treadmill and swimming tests on rats. The new substance showed greater or equal effects compared to the reference actoprotector drugs metaprot and ladasten in much higher doses. The gluconeogenesis inhibitor tryptophan significantly (74 ± 5%, p < 0.01) prevented this stimulatory effect of 3-HPA in the treadmill test on rats. 3-HPA at a higher dose (30 mg/kg) had marked antiamnesic effect on various models of amnesia in mice. It was more effective than reference drugs mexidol (another 3-HP derivative) in a dose of 30 mg/kg and nootropic drug piracetam in a dose of 200 mg/kg, but had equal effect with these drugs in doses of 50 and 800 mg/kg, respectively. 3-HPA (30 mg/kg per day) had neuroprotective effect in rats with brain ischemia and decreased the neurologic deficiency more effectively than mexidol (50 mg/kg per day).

Topics: Adamantane; Amnesia; Animals; Animals, Outbred Strains; Anticonvulsants; Benzimidazoles; Brain Ischemia; Disease Models, Animal; Exercise Test; Gluconeogenesis; Male; Mice; Neuroprotective Agents; Nootropic Agents; Physical Conditioning, Animal; Picolines; Piracetam; Rats; Swimming; Tryptophan

Intraperitoneal injection of bemithyl in a dose of 25 mg/kg for 3 days after craniocerebral injury reduced psychopathological symptoms in rats with different resistance to acute hypoxia, restored the structure of individual behavior, and prevented metabolic disorders in the brain.

Topics: Animals; Antioxidants; Benzimidazoles; Body Weight; Brain; Brain Injuries; Carbon Tetrachloride Poisoning; Craniocerebral Trauma; Disease Models, Animal; Hypoxia; Injections, Intraperitoneal; Male; Metabolic Diseases; Neuroprotective Agents; Piracetam; Rats; Temperature; Time Factors