bemesetron and Seizures

bemesetron has been researched along with Seizures* in 2 studies

Other Studies

2 other study(ies) available for bemesetron and Seizures

Article	Year
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH Bioorganic & medicinal chemistry, 2017, 01-15, Volume: 25, Issue:2 A series of twenty two (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship	2017
The 5-HT3 antagonist MDL-72222 exacerbates ethanol withdrawal seizures in mice. Alcoholism, clinical and experimental research, 1994, Volume: 18, Issue:2 Ethanol-dependent mice were treated with the 5-HT3 antagonist MDL 72222 after withdrawal from ethanol. Treatment with unit doses (0, 5.6, 10, and 17.0 mg/kg) of MDL 72222 at 0, 4, and 7 hr after withdrawal dose-dependently exacerbated the severity of ethanol withdrawal seizures. Treatment with a single dose (17 mg/kg) of MDL 72222 at 5 hr after withdrawal also exacerbated the severity of ethanol withdrawal seizures. Ethanol naive mice treated with MDL 72222 (56 mg/kg) did not display any seizures. Treatment with another 5-HT3 antagonist, ICS 205-930 (23 and 46 mg/kg), or the 5-HT2 receptor antagonist ketanserin, did not affect ethanol withdrawal seizures. The findings suggest MDL 72222 selectively enhances sensitivity to withdrawal seizures following chronic ethanol exposure. Topics: Alcohol Withdrawal Delirium; Animals; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentials; Ketanserin; Male; Mice; Mice, Inbred C57BL; Postural Balance; Receptors, Serotonin; Seizures; Serotonin Antagonists; Stimulation, Chemical; Tropanes	1994

Article

Year

Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH

Bioorganic & medicinal chemistry, 2017, 01-15, Volume: 25, Issue:2

A series of twenty two (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH

Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship

2017

The 5-HT3 antagonist MDL-72222 exacerbates ethanol withdrawal seizures in mice.

Alcoholism, clinical and experimental research, 1994, Volume: 18, Issue:2

Ethanol-dependent mice were treated with the 5-HT3 antagonist MDL 72222 after withdrawal from ethanol. Treatment with unit doses (0, 5.6, 10, and 17.0 mg/kg) of MDL 72222 at 0, 4, and 7 hr after withdrawal dose-dependently exacerbated the severity of ethanol withdrawal seizures. Treatment with a single dose (17 mg/kg) of MDL 72222 at 5 hr after withdrawal also exacerbated the severity of ethanol withdrawal seizures. Ethanol naive mice treated with MDL 72222 (56 mg/kg) did not display any seizures. Treatment with another 5-HT3 antagonist, ICS 205-930 (23 and 46 mg/kg), or the 5-HT2 receptor antagonist ketanserin, did not affect ethanol withdrawal seizures. The findings suggest MDL 72222 selectively enhances sensitivity to withdrawal seizures following chronic ethanol exposure.

Topics: Alcohol Withdrawal Delirium; Animals; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentials; Ketanserin; Male; Mice; Mice, Inbred C57BL; Postural Balance; Receptors, Serotonin; Seizures; Serotonin Antagonists; Stimulation, Chemical; Tropanes

1994