bemesetron and Inflammation

bemesetron has been researched along with Inflammation* in 2 studies

Other Studies

2 other study(ies) available for bemesetron and Inflammation

Article	Year
Mechanisms of analgesic action of pulsed radiofrequency on adjuvant-induced pain in the rat: roles of descending adrenergic and serotonergic systems. European journal of pain (London, England), 2009, Volume: 13, Issue:3 Pulsed radiofrequency (PRF) has been reported to be effective in the treatment of several types of pain. The mechanism of action, however, is not well known. In a recent study, the antinociceptive effects of acute thermal pain were shown to be mediated via descending pain inhibitory pathways. In this study we observed an analgesic effect of PRF treatment in an adjuvant induced inflammatory pain model in rats. In this model, sciatic nerves were treated with PRF at 37 degrees and 42 degrees , which inhibited hyperalgesia in the inflammatory groups when compared to RF and sham treatment. This effect was attenuated after intrathecal administration of the alpha2-adrenoceptor antagonist yohimbine, the selective 5-HT3 serotonin receptor antagonist MDL72222, and the non-selective serotonin receptor antagonist methysergide. All three drugs were found to significantly inhibit the analgesic effect of PRF. The results suggest that the analgesic action of PRF involves the enhancement of noradrenergic and serotonergic descending pain inhibitory pathways. Topics: Adrenergic alpha-Antagonists; Analgesia; Animals; Brain Stem; Catecholamines; Catheter Ablation; Disease Models, Animal; Efferent Pathways; Freund's Adjuvant; Inflammation; Male; Neural Inhibition; Nociceptors; Pain; Pain Management; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Serotonin; Serotonin Antagonists; Treatment Outcome; Tropanes; Yohimbine	2009
Antinociceptive effects of intrathecally administered 2-methylserotonin in developing rats. Brain research. Developmental brain research, 1997, Jan-02, Volume: 98, Issue:1 The present study examined developmental patterns of antinociception mediated by the spinal 5-HT3 receptor system in the neonatal rat. Intrathecally administered 2-methylserotonin (25-100 micrograms) first produced antinociception against formalin-induced acute inflammatory pain at 10 days postnatally, with effect only at the peak dose (100 micrograms). Intrathecal 2-methylserotonin produced dose-dependent antinociception at 14 and 28 days of age that was attenuated by i.t. pretreatment with the 5-HT3 receptor antagonist MDL-72222 (10 micrograms). Topics: Animals; Animals, Newborn; Dose-Response Relationship, Drug; Formaldehyde; Inflammation; Injections, Spinal; Male; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spinal Cord; Tropanes	1997

Article

Year

Mechanisms of analgesic action of pulsed radiofrequency on adjuvant-induced pain in the rat: roles of descending adrenergic and serotonergic systems.

European journal of pain (London, England), 2009, Volume: 13, Issue:3

Pulsed radiofrequency (PRF) has been reported to be effective in the treatment of several types of pain. The mechanism of action, however, is not well known. In a recent study, the antinociceptive effects of acute thermal pain were shown to be mediated via descending pain inhibitory pathways. In this study we observed an analgesic effect of PRF treatment in an adjuvant induced inflammatory pain model in rats. In this model, sciatic nerves were treated with PRF at 37 degrees and 42 degrees , which inhibited hyperalgesia in the inflammatory groups when compared to RF and sham treatment. This effect was attenuated after intrathecal administration of the alpha2-adrenoceptor antagonist yohimbine, the selective 5-HT3 serotonin receptor antagonist MDL72222, and the non-selective serotonin receptor antagonist methysergide. All three drugs were found to significantly inhibit the analgesic effect of PRF. The results suggest that the analgesic action of PRF involves the enhancement of noradrenergic and serotonergic descending pain inhibitory pathways.

Topics: Adrenergic alpha-Antagonists; Analgesia; Animals; Brain Stem; Catecholamines; Catheter Ablation; Disease Models, Animal; Efferent Pathways; Freund's Adjuvant; Inflammation; Male; Neural Inhibition; Nociceptors; Pain; Pain Management; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Serotonin; Serotonin Antagonists; Treatment Outcome; Tropanes; Yohimbine

2009

Antinociceptive effects of intrathecally administered 2-methylserotonin in developing rats.

Brain research. Developmental brain research, 1997, Jan-02, Volume: 98, Issue:1

The present study examined developmental patterns of antinociception mediated by the spinal 5-HT3 receptor system in the neonatal rat. Intrathecally administered 2-methylserotonin (25-100 micrograms) first produced antinociception against formalin-induced acute inflammatory pain at 10 days postnatally, with effect only at the peak dose (100 micrograms). Intrathecal 2-methylserotonin produced dose-dependent antinociception at 14 and 28 days of age that was attenuated by i.t. pretreatment with the 5-HT3 receptor antagonist MDL-72222 (10 micrograms).

Topics: Animals; Animals, Newborn; Dose-Response Relationship, Drug; Formaldehyde; Inflammation; Injections, Spinal; Male; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spinal Cord; Tropanes

1997