bemesetron has been researched along with Hyperventilation* in 1 studies
1 other study(ies) available for bemesetron and Hyperventilation
| Article | Year |
|---|---|
Mediation of serotonin-induced hyperventilation via 5-HT3-receptor in European eel Anguilla anguilla.
The effects of serotonin (5-hydroxytryptamine) on ventilation were investigated by continuous measurements of intrabuccal pressure in unrestrained eel. Intravenous administration of 5-hydroxytryptamine (30 micrograms.kg-1) caused a large increase in ventilatory frequency (+ 100%) and amplitude (+ 140%). The 5-hydroxytryptamine-induced hyperventilation was blocked by the 5-HT3-receptor antagonists metoclopramide (1.0 mg.kg-1) or MDL72222 (1.0 mg.kg-1), and was insensitive to the 5-HT1/2-receptor antagonist methysergide (3.0 mg.kg-1) and to the 5-HT4-receptor antagonist DAU 6285 CL (3.0 mg.kg-1). The hyperventilatory response to 5-hydroxytryptamine could be mimicked by the 5-HT3 receptor agonist 1-phenylbiguanide (300 micrograms.kg-1). These results strongly implicate the 5-HT3-receptor as the mediator of the 5-hydroxytryptamine-induced hyperventilation in eel. Topics: Anguilla; Animals; Benzimidazoles; Biguanides; Bridged Bicyclo Compounds, Heterocyclic; Hyperventilation; Injections, Intravenous; Methysergide; Metoclopramide; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Respiration; Serotonin; Serotonin Antagonists; Tropanes | 1996 |