bekanamycin and Proteinuria

The aminoglycosides butirosin and bekanamycin (Kanendomycin) were tested for their nephrotoxicity in female albino Wistar rats (n = 110). The antibiotics were administered i.m. over a course of 5 days; dosage interval 12 h, dosage 2,5, 5, 10, 20, 100 and 500 mg/kg per day, respectively. For comparative evaluation of nephrotoxicity the urinary excretion of tubular cells and enzymes (MDH, GOT, LDH) were taken. Additionally, serum urea and urine protein (qualitatively) were determined, and the kidneys were investigated histologically. The experiments revealed that both aminoglycosides had tubulotoxic and glomerulotoxic effects. The lowest doses that induced pathologic cell excretion (tubulotoxic threshold doses) were 5 mg/kg per day for either drug. It may be concluded that nephrotoxicity of butirosin and bekanamycin does not differ within the range of dosages which are used in human therapy. Compared with other established aminoglycosides advantages with respect to nephrotoxicity could not be found.

Topics: Animals; Anti-Bacterial Agents; Butirosin Sulfate; Enzymes; Female; Kanamycin; Kidney; Kidney Diseases; Proteinuria; Rats; Time Factors; Urea