Page last updated: 2024-09-05

bd 1047 and Disease Models, Animal

bd 1047 has been researched along with Disease Models, Animal in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.26)18.2507
2000's7 (36.84)29.6817
2010's10 (52.63)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV1
Kadnikov, IA; Seredenin, SB; Voronin, MV; Voronkov, DN1
Roh, DH; Yoon, SY1
Beitz, AJ; Choi, HS; Choi, SR; Han, HJ; Kang, SY; Kim, HW; Kwon, SG; Lee, JH; Moon, JY; Oh, SB; Roh, DH; Yoon, SY1
Kang, SY; Kim, HC; Kim, HW; Roh, DH; Yoon, SY1
Jeong, YC; Kwon, YB; Son, JS1
Han, Y; Hu, X; Liu, Y; Song, C; Wang, C; Zhu, S1
Beitz, AJ; Choi, HS; Choi, SR; Kang, SY; Kwon, SG; Lee, JH; Moon, JY; Roh, DH; Yoon, SY1
Beitz, AJ; Choi, HS; Choi, SR; Han, HJ; Kwon, SG; Lee, JH; Roh, DH; Yoon, SY1
Beitz, AJ; Choi, HS; Choi, SR; Han, HJ; Kang, SY; Kwon, SG; Lee, JH; Moon, JY; Roh, DH; Yoon, SY2
Beitz, AJ; Han, HJ; Kim, HW; Kim, KW; Kwon, YB; Lee, JH; Roh, DH; Seo, HS; Yoon, SY2
Antonini, V; Arena, E; Coradazzi, M; Leanza, G; Marrazzo, A; Prezzavento, O; Ronsisvalle, S1
Baldwin, GC; Choi, R; Roth, MD; Tashkin, DP; Whittaker, KM1
Egashira, N; Fujiwara, M; Harada, S; Iwasaki, K; Matsushita, M; Mishima, K; Nishimura, R; Okuno, R; Orito, K1
Coop, A; Mack, AL; Matsumoto, RR; Wang, J1
Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I1
Bowen, WD; De Costa, BR; Matsumoto, RR; Tom, MA; Truong, DD; Vo, VN1

Other Studies

19 other study(ies) available for bd 1047 and Disease Models, Animal

ArticleYear
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

2020
Chaperone Sigma1R mediates the neuroprotective action of afobazole in the 6-OHDA model of Parkinson's disease.
    Scientific reports, 2019, 11-19, Volume: 9, Issue:1

    Topics: Animals; Benzimidazoles; Corpus Striatum; Disease Models, Animal; Dopamine; Ethylenediamines; Male; Mice; Mice, Inbred ICR; Morpholines; Neurons; Neuroprotection; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Receptors, sigma; Rotarod Performance Test; Sigma-1 Receptor; Substantia Nigra

2019
Sigma-1 receptor antagonist, BD1047 reduces nociceptive responses and phosphorylation of p38 MAPK in mice orofacial formalin model.
    Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:1

    Topics: Analgesics; Animals; Disease Models, Animal; Ethylenediamines; Facial Pain; Formaldehyde; Lip; Male; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-fos; Receptors, sigma; Sigma-1 Receptor; Signal Transduction

2014
Spinal sigma-1 receptor activation increases the production of D-serine in astrocytes which contributes to the development of mechanical allodynia in a mouse model of neuropathic pain.
    Pharmacological research, 2015, Volume: 100

    Topics: Animals; Astrocytes; Disease Models, Animal; Ethylenediamines; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Neuralgia; Posterior Horn Cells; Racemases and Epimerases; Receptors, sigma; Serine; Sigma-1 Receptor; Spinal Cord

2015
Clonidine Reduces Nociceptive Responses in Mouse Orofacial Formalin Model: Potentiation by Sigma-1 Receptor Antagonist BD1047 without Impaired Motor Coordination.
    Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:9

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics; Animals; Blood Pressure; Clonidine; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Ethylenediamines; Facial Pain; Formaldehyde; Male; Mice, Inbred C57BL; Pain Measurement; Psychomotor Performance; Receptors, sigma; Rotarod Performance Test; Sigma-1 Receptor

2015
The spinal antinociceptive mechanism determined by systemic administration of BD1047 in zymosan-induced hyperalgesia in rats.
    Brain research bulletin, 2015, Volume: 119, Issue:Pt A

    Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ethylenediamines; Hyperalgesia; Male; Microglia; Pain; Posterior Horn Cells; Rats, Sprague-Dawley; Receptors, sigma; Spinal Cord; Zymosan

2015
Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation.
    Mediators of inflammation, 2015, Volume: 2015

    Topics: Animals; Bone Neoplasms; Disease Models, Animal; Ethylenediamines; Extracellular Signal-Regulated MAP Kinases; Female; Hyperalgesia; Microglia; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor; Spinal Cord

2015
Peripheral neurosteroids enhance P2X receptor-induced mechanical allodynia via a sigma-1 receptor-mediated mechanism.
    Brain research bulletin, 2016, Volume: 121

    Topics: Adenosine Triphosphate; Animals; Dehydroepiandrosterone Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Ethylenediamines; Hyperalgesia; Male; Pain Measurement; Pregnenolone; Purinergic P2X Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X; Receptors, sigma; Time Factors

2016
Astrocyte sigma-1 receptors modulate connexin 43 expression leading to the induction of below-level mechanical allodynia in spinal cord injured mice.
    Neuropharmacology, 2016, Volume: 111

    Topics: Animals; Astrocytes; Connexin 43; Disease Models, Animal; Ethylenediamines; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Neuralgia; Receptors, sigma; Sigma-1 Receptor; Spinal Cord Dorsal Horn; Spinal Cord Injuries

2016
Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain.
    The journal of pain, 2017, Volume: 18, Issue:4

    Topics: Animals; D-Amino-Acid Oxidase; Disease Models, Animal; Enzyme Inhibitors; Ethylenediamines; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Morpholines; N-Methylaspartate; Nerve Tissue Proteins; Neuralgia; Phosphorylation; Physical Stimulation; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Serine; Sigma-1 Receptor; Spinal Cord

2017
Intrathecal administration of sigma-1 receptor agonists facilitates nociception: involvement of a protein kinase C-dependent pathway.
    Journal of neuroscience research, 2008, Volume: 86, Issue:16

    Topics: Animals; Antitussive Agents; Calcium Signaling; Cyclopentanes; Disease Models, Animal; Enzyme Inhibitors; Ethylenediamines; Inflammation Mediators; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morpholines; Nociceptors; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells; Protein Kinase C; Proto-Oncogene Proteins c-fos; Receptors, sigma; Sigma-1 Receptor; Signal Transduction; Spinal Cord

2008
Anti-amnesic properties of (+/-)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats.
    Journal of neurochemistry, 2009, Volume: 109, Issue:3

    Topics: Acetylcholine; Animals; Antibodies, Monoclonal; Atropine; Behavior, Animal; Cognition Disorders; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylenediamines; Female; Maze Learning; Memory, Short-Term; Motor Activity; Muscarinic Antagonists; Nootropic Agents; Piperidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, sigma; Ribosome Inactivating Proteins, Type 1; Saporins

2009
Sigma-1 receptor-mediated increase in spinal p38 MAPK phosphorylation leads to the induction of mechanical allodynia in mice and neuropathic rats.
    Experimental neurology, 2013, Volume: 247

    Topics: Analysis of Variance; Animals; Disease Models, Animal; Enzyme Inhibitors; Ethylenediamines; Hyperalgesia; Imidazoles; Male; Mice; Mice, Inbred ICR; Morpholines; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sciatica; Sigma-1 Receptor; Spinal Cord

2013
Cocaine and sigma-1 receptors modulate HIV infection, chemokine receptors, and the HPA axis in the huPBL-SCID model.
    Journal of leukocyte biology, 2005, Volume: 78, Issue:6

    Topics: Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Ethylenediamines; Female; HIV; HIV Infections; Humans; Hypothalamo-Hypophyseal System; Immune Tolerance; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Mice, SCID; Pituitary-Adrenal System; Receptors, CCR5; Receptors, Chemokine; Receptors, CXCR4; Receptors, sigma; Sigma-1 Receptor; Transplantation, Heterologous; Viral Load

2005
Involvement of the sigma1 receptor in inhibiting activity of fluvoxamine on marble-burying behavior: comparison with paroxetine.
    European journal of pharmacology, 2007, Jun-01, Volume: 563, Issue:1-3

    Topics: Animals; Behavior, Animal; Brain; Butyrates; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylenediamines; Fluvoxamine; Male; Mice; Mice, Inbred ICR; Morpholines; Obsessive-Compulsive Disorder; Paroxetine; Phenazocine; Piperazines; Psychotropic Drugs; Receptors, sigma; Selective Serotonin Reuptake Inhibitors; Sigma-1 Receptor; Tropanes

2007
Novel sigma (sigma) receptor agonists produce antidepressant-like effects in mice.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2007, Volume: 17, Issue:11

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Ethylenediamines; Freezing Reaction, Cataleptic; Male; Mice; Motor Activity; Piperidines; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma; Swimming

2007
Sigma 1 receptor-mediated increase in hippocampal extracellular dopamine contributes to the mechanism of the anticonvulsant action of neuropeptide Y.
    The European journal of neuroscience, 2007, Volume: 26, Issue:11

    Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Epilepsy; Ethylenediamines; Hippocampus; Male; Microdialysis; Neuropeptide Y; Pilocarpine; Rats; Rats, Wistar; Receptors, sigma; Remoxipride; Severity of Illness Index; Sigma-1 Receptor; Time Factors

2007
Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice.
    British journal of pharmacology, 2008, Volume: 154, Issue:5

    Topics: Animals; Behavior, Animal; Blotting, Western; Cyclic AMP-Dependent Protein Kinases; Cyclopentanes; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylenediamines; Immunohistochemistry; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morpholines; N-Methylaspartate; Pain; Pain Measurement; Phosphorylation; Posterior Horn Cells; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Serine; Sigma-1 Receptor; Signal Processing, Computer-Assisted; Signal Transduction; Spinal Cord; Time Factors

2008
Characterization of two novel sigma receptor ligands: antidystonic effects in rats suggest sigma receptor antagonism.
    European journal of pharmacology, 1995, Jul-14, Volume: 280, Issue:3

    Topics: Animals; Anticonvulsants; Behavior, Animal; Binding, Competitive; Brain; Disease Models, Animal; Dystonia; Ethylenediamines; Guanidines; Ligands; Male; Piperazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma; Structure-Activity Relationship

1995