bay-k-8644 has been researched along with Subarachnoid Hemorrhage in 2 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Arteries that develop vasospasm after subarachnoid hemorrhage (SAH) may have altered contractility and compliance." | 1.33 | Calcium sensitivity of vasospastic basilar artery after experimental subarachnoid hemorrhage. ( Larkin, L; Macdonald, RL; Nikitina, E; Takahashi, M; Xie, A; Young, J; Zhang, ZD, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duan, HZ | 1 |
| Wu, CW | 1 |
| Shen, SL | 1 |
| Zhang, JY | 1 |
| Li, L | 1 |
| Macdonald, RL | 1 |
| Zhang, ZD | 1 |
| Takahashi, M | 1 |
| Nikitina, E | 1 |
| Young, J | 1 |
| Xie, A | 1 |
| Larkin, L | 1 |
2 other studies available for bay-k-8644 and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
Neuroprotective Effects of Early Brain Injury after Subarachnoid Hemorrhage in Rats by Calcium Channel Mediating Hydrogen Sulfide.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2021 |
Calcium sensitivity of vasospastic basilar artery after experimental subarachnoid hemorrhage.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2006 |