bay-k-8644 has been researched along with Pregnancy in 36 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The hypothesis that Ca2+ channel function is altered during pregnancy was tested by comparing responses to potassium chloride (KCl) and phenylephrine in aortic rings of virgin and term-pregnant rats under the influence of nifedipine and Bay K 8644." | 3.69 | Effects of nifedipine and Bay K 8644 on myotropic responses in aortic rings of pregnant rats. ( Brochu, M; Roy, B; Sicotte, B; St-Louis, J, 1995) |
| "Fetal membranes from women in preterm labor had the least amount of measured endogenous calcium channel inhibitor activity." | 1.31 | Abnormality of calcium channel inhibitor released from fetal membranes in preterm labor. ( Carroll, EM; Collins, PL; Gianopoulos, JG, 2001) |
| "Nifedipine and CGP 28392 treatment of nonpregnant and pregnant animals, respectively, did not modify the response of aortic rings to KCl." | 1.31 | Calcium channels contribute to the decrease in blood pressure of pregnant rats. ( Brochu, M; Cadorette, C; Poterek, M; Simaan, M; St-Louis, J, 2002) |
| " BAY K 8644 produced a larger increase in sensitivity in adrenal capsule preparations from pregnant than from nonpregnant rats, leading to superposition of the two dose-response curves to K+." | 1.30 | Effects of dihydropyridines on aldosterone secretion in adrenal capsule preparations from pregnant rats. ( Brochu, M; Jodoin, S; Picard, S; St-Louis, J, 1997) |
| "When uterine muscle was exposed to full-thickness fetal membranes (amnion-chorion with attached decidua) or to the intact fetal components (chorion-amnion) or to chorion alone, the Bay K 8644 dose-response curve was significantly shifted to the right." | 1.29 | Human fetal membranes inhibit calcium L-channel activated uterine contractions. ( Collins, PL; Idriss, E; Kulp, TM; Moore, JJ, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (13.89) | 18.7374 |
| 1990's | 15 (41.67) | 18.2507 |
| 2000's | 12 (33.33) | 29.6817 |
| 2010's | 3 (8.33) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Alotaibi, MF | 1 |
| Banciu, A | 1 |
| Banciu, DD | 1 |
| Mustaciosu, CC | 1 |
| Radu, M | 1 |
| Cretoiu, D | 1 |
| Xiao, J | 1 |
| Cretoiu, SM | 1 |
| Suciu, N | 1 |
| Radu, BM | 1 |
| Fernández-Morales, JC | 1 |
| Cortés-Gil, L | 1 |
| García, AG | 1 |
| de Diego, AM | 1 |
| Paillusson, S | 1 |
| Tasselli, M | 1 |
| Lebouvier, T | 1 |
| Mahé, MM | 1 |
| Chevalier, J | 1 |
| Biraud, M | 1 |
| Cario-Toumaniantz, C | 1 |
| Neunlist, M | 1 |
| Derkinderen, P | 1 |
| Kim, YH | 1 |
| Chung, S | 1 |
| Lee, YH | 1 |
| Kim, EC | 1 |
| Ahn, DS | 1 |
| Murphy, JG | 1 |
| Herrington, JN | 1 |
| Granger, JP | 1 |
| Khalil, RA | 1 |
| Monir-Bishty, E | 1 |
| Pierce, SJ | 1 |
| Kupittayanant, S | 1 |
| Shmygol, A | 1 |
| Wray, S | 2 |
| Blake, BL | 1 |
| Muehlmann, AM | 1 |
| Egami, K | 1 |
| Breese, GR | 1 |
| Devine, DP | 1 |
| Jinnah, HA | 1 |
| Salemme, S | 1 |
| Rebolledo, A | 1 |
| Speroni, F | 1 |
| Petruccelli, S | 1 |
| Milesi, V | 1 |
| Lei, G | 1 |
| Xia, Y | 1 |
| Johnson, KM | 1 |
| Bellemann, P | 1 |
| Roy, B | 1 |
| Sicotte, B | 1 |
| Brochu, M | 4 |
| St-Louis, J | 4 |
| Thibault, O | 1 |
| Porter, NM | 1 |
| Landfield, PW | 1 |
| Barrús, MT | 2 |
| Reviriego, J | 2 |
| Marín, J | 2 |
| Petit, A | 1 |
| Gallo-Payet, N | 1 |
| Vaillancourt, C | 1 |
| Bellabarba, D | 1 |
| Lehoux, JG | 1 |
| Bélisle, S | 1 |
| Liu, YA | 1 |
| Ostlund, E | 1 |
| Fried, G | 1 |
| Collins, PL | 3 |
| Moore, JJ | 2 |
| Idriss, E | 1 |
| Kulp, TM | 1 |
| Picard, S | 2 |
| Jodoin, S | 1 |
| Jones, GV | 1 |
| Taylor, KR | 1 |
| Morgan, G | 1 |
| Wooding, FB | 1 |
| Care, AD | 1 |
| Nonaka, A | 1 |
| Kashimoto, S | 1 |
| Imamura, M | 1 |
| Furuya, A | 1 |
| Kumazawa, T | 1 |
| Taggart, MJ | 1 |
| Sheader, EA | 1 |
| Walker, SD | 1 |
| Naderali, EK | 1 |
| Moore, S | 1 |
| Brosenitsch, TA | 1 |
| Salgado-Commissariat, D | 1 |
| Kunze, DL | 1 |
| Katz, DM | 1 |
| Barger, SW | 1 |
| Chen, L | 1 |
| El-Sherif, N | 1 |
| Boutjdir, M | 1 |
| Simaan, M | 2 |
| Lundgren, DW | 1 |
| Choobineh, E | 1 |
| Chang, SM | 1 |
| Chang, AS | 1 |
| Carroll, EM | 1 |
| Gianopoulos, JG | 1 |
| Cadorette, C | 1 |
| Poterek, M | 1 |
| Venuto, R | 1 |
| Brown, G | 1 |
| Schoenl, M | 1 |
| Losonczy, G | 1 |
| Houlihan, DD | 1 |
| Dennedy, MC | 1 |
| Morrison, JJ | 1 |
| Calixto, JB | 1 |
| Rae, GA | 1 |
| Creba, JA | 1 |
| Karobath, M | 1 |
| Ebeigbe, AB | 1 |
| Ezimokhai, M | 1 |
| Aloamaka, CP | 1 |
| MacLennan, SJ | 1 |
| McGrath, JC | 1 |
| Whittle, MJ | 1 |
| Poli, E | 1 |
| Rusagara, JN | 1 |
| Coruzzi, G | 1 |
| Bertaccini, G | 1 |
36 other studies available for bay-k-8644 and Pregnancy
| Article | Year |
|---|---|
Pimpinella anisum extract attenuates spontaneous and agonist-induced uterine contraction in term-pregnant rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2020 |
Beta-Estradiol Regulates Voltage-Gated Calcium Channels and Estrogen Receptors in Telocytes from Human Myometrium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2018 |
Differences in the quantal release of catecholamines in chromaffin cells of rat embryos and their mothers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2009 |
α-Synuclein expression is induced by depolarization and cyclic AMP in enteric neurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2010 |
Increase of L-type Ca2+ current by protease-activated receptor 2 activation contributes to augmentation of spontaneous uterine contractility in pregnant rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2012 |
Enhanced [Ca2+]i in renal arterial smooth muscle cells of pregnant rats with reduced uterine perfusion pressure.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2003 |
The effects of metabolic inhibition on intracellular calcium and contractility of human myometrium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2003 |
Nifedipine suppresses self-injurious behaviors in animals.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2007 |
L, P-/Q- and T-type Ca2+ channels in smooth muscle cells from human umbilical artery.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2007 |
The role of Akt-GSK-3beta signaling and synaptic strength in phencyclidine-induced neurodegeneration.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2008 |
Binding properties of a novel calcium channel activating dihydropyridine in monolayer cultures of beating myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1984 |
Effects of nifedipine and Bay K 8644 on myotropic responses in aortic rings of pregnant rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Low Ba2+ and Ca2+ induce a sustained high probability of repolarization openings of L-type Ca2+ channels in hippocampal neurons: physiological implications.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Effect of Ca2+ agonist Bay K 8644 in human placental arteries.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
A role for extracellular calcium in the regulation of placental lactogen release by angiotensin-II and dopamine in human term trophoblastic cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Endothelin-induced contractions in human placental blood vessels are enhanced in intrauterine growth retardation, and modulated by agents that regulate levels of intracellular calcium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Effect of the Ca(2+)-channel agonist Bay K 8644 on the contractile responses in human placental veins.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1996 |
Human fetal membranes inhibit calcium L-channel activated uterine contractions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1996 |
Effects of dihydropyridines on aldosterone secretion in adrenal capsule preparations from pregnant rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Aspects of calcium transport by the ovine placenta: studies based on the interplacentomal region of the chorion.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Mechanism of the negative inotropic effect of midazolam and diazepam in cultured foetal mouse cardiac myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
External alkalinization decreases intracellular Ca++ and spontaneous contractions in pregnant rat myometrium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
A role for L-type calcium channels in developmental regulation of transmitter phenotype in primary sensory neurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1998 |
Complex influence of the L-type calcium-channel agonist BayK8644(+/-) on N-methyl-D-aspartate responses and neuronal survival.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Unitary current analysis of L-type Ca2+ channels in human fetal ventricular myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Functional alteration of dihydropyridine-sensitive Ca(2+) channels in the adrenal glomerulosa of pregnant rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2000 |
Gestational changes in uterine L-type calcium channel function and expression in guinea pig.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2000 |
Abnormality of calcium channel inhibitor released from fetal membranes in preterm labor.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2001 |
Calcium channels contribute to the decrease in blood pressure of pregnant rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |
Enhanced vascular effects of the Ca(2+) channel agonist Bay K 8644 in pregnant rabbits.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |
Polyamine effects on human myometrial contractility.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |
Effects of endothelins, Bay K 8644 and other oxytocics in non-pregnant and late pregnant rat isolated uterus.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Modulation of depolarization stimulated 45Ca2+ uptake in cultured neuronal cells by calcium channel activators and antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1986 |
Responses of arterial smooth muscle from normotensive and pre-eclamptic subjects to the calcium channel agonist, Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Inhibition of the oxygen-induced contraction of the isolated human umbilical artery by indomethacin, flurbiprofen, aspirin and drugs modifying Ca2+ disposition.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1988 |
Dihydropyridine receptors in the pregnant human uterus in vitro.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1989 |