bay-k-8644 has been researched along with Pituitary Neoplasms in 33 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serum from patients with IDDM increased L-type calcium channel activity of insulin-producing cells and of GH3 cells derived from a pituitary tumor." | 1.29 | Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes. ( Ammälä, C; Bokvist, K; Dypbukt, J; Hallberg, A; Juntti-Berggren, L; Larsson, O; Nicotera, P; Orrenius, S; Rorsman, P; Wåhlander, K, 1993) |
| "Lidocaine was much less effective in inhibiting secretion induced by 1 microM phorbol 12-myristate 13-acetate (TPA) or 5 microM forskolin." | 1.28 | Lidocaine inhibits prolactin secretion in GH4C1 cells by blocking calcium influx. ( Greer, MA; Sato, N; Wang, X, 1992) |
| "Pretreatment with thapsigargin blocked the ability of TRH to cause a transient increase in both [Ca2+]c and 45Ca2+ efflux." | 1.28 | Thapsigargin, but not caffeine, blocks the ability of thyrotropin-releasing hormone to release Ca2+ from an intracellular store in GH4C1 pituitary cells. ( Dannies, PS; Hanley, MR; Law, GJ; Pachter, JA; Thastrup, O, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (45.45) | 18.7374 |
| 1990's | 17 (51.52) | 18.2507 |
| 2000's | 1 (3.03) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dominguez, B | 1 |
| Felix, R | 1 |
| Monjaraz, E | 1 |
| Enyeart, JJ | 5 |
| Hinkle, PM | 8 |
| Sheppard, KE | 1 |
| Haymes, AA | 2 |
| Juntti-Berggren, L | 1 |
| Larsson, O | 1 |
| Rorsman, P | 1 |
| Ammälä, C | 1 |
| Bokvist, K | 1 |
| Wåhlander, K | 1 |
| Nicotera, P | 1 |
| Dypbukt, J | 1 |
| Orrenius, S | 1 |
| Hallberg, A | 1 |
| Nelson, EJ | 2 |
| Forget, H | 1 |
| Painson, JC | 1 |
| Drews, RT | 1 |
| Lagacé, G | 1 |
| Collu, R | 1 |
| Cataldi, M | 1 |
| Taglialatela, M | 1 |
| Guerriero, S | 1 |
| Amoroso, S | 1 |
| Lombardi, G | 1 |
| di Renzo, G | 1 |
| Annunziato, L | 1 |
| Li, P | 1 |
| Thaw, CN | 1 |
| Sempowski, GD | 1 |
| Gershengorn, MC | 1 |
| Wang, X | 3 |
| Sato, N | 2 |
| Greer, MA | 3 |
| Inukai, T | 1 |
| Shanshala, ED | 1 |
| Duchemin, AM | 1 |
| Enyeart, JA | 1 |
| Biagi, BA | 2 |
| Foster, DN | 1 |
| Mlinar, B | 1 |
| Law, GJ | 1 |
| Pachter, JA | 1 |
| Thastrup, O | 1 |
| Hanley, MR | 1 |
| Dannies, PS | 1 |
| Day, RN | 2 |
| Sheu, SS | 2 |
| Maurer, RA | 1 |
| Heisler, S | 4 |
| Gollasch, M | 1 |
| Haller, H | 1 |
| Schultz, G | 1 |
| Hescheler, J | 2 |
| Scherübl, H | 1 |
| Cronin, MJ | 1 |
| Anderson, JM | 1 |
| Rogol, AD | 1 |
| Koritnik, DR | 1 |
| Thorner, MO | 1 |
| Evans, WS | 1 |
| Aizawa, T | 1 |
| Armstrong, D | 1 |
| Eckert, R | 1 |
| Laverriere, JN | 2 |
| Tixier-Vidal, A | 2 |
| Buisson, N | 2 |
| Morin, A | 1 |
| Martial, JA | 2 |
| Gourdji, D | 2 |
| Wark, JD | 1 |
| Gurtler, V | 1 |
| Yamashita, N | 1 |
| Matsunaga, H | 1 |
| Shibuya, N | 1 |
| Teramoto, A | 1 |
| Takakura, K | 1 |
| Ogata, E | 1 |
| Jackson, AE | 1 |
| Bancroft, C | 1 |
| Richard, JL | 1 |
| Shangold, GA | 1 |
| Kongsamut, S | 1 |
| Miller, RJ | 1 |
33 other studies available for bay-k-8644 and Pituitary Neoplasms
| Article | Year |
|---|---|
Ghrelin and GHRP-6 enhance electrical and secretory activity in GC somatotropes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2007 |
The calcium agonist Bay K 8644 stimulates secretion from a pituitary cell line.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1984 |
Calcium and protein kinase C regulation of the glucocorticoid receptor in mouse corticotrope tumor cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Activation of protein kinase C increases Ca2+ sensitivity of secretory response of GH3 pituitary cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Regulation of L-type voltage-gated calcium channels by epidermal growth factor.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifl | 1993 |
MMQ cells: a model for evaluating the role of G proteins in the modulation of prolactin release.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Protein-tyrosine kinases activate while protein-tyrosine phosphatases inhibit L-type calcium channel activity in pituitary GH3 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1996 |
Characterization of the calcium response to thyrotropin-releasing hormone (TRH) in cells transfected with TRH receptor complementary DNA: importance of voltage-sensitive calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Lidocaine inhibits prolactin secretion in GH4C1 cells by blocking calcium influx.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Alpha-adrenergic inhibition of thyrotropin-releasing hormone-induced prolactin secretion in GH4C1 cells is associated with a depressed rise in intracellular Ca2+.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Measurement of intracellular cadmium with fluorescent dyes. Further evidence for the role of calcium channels in cadmium uptake.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Ca2+ channel modulation and kinase-C activation in a pituitary cell line: induction of immediate early genes and inhibition of proliferation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Thapsigargin, but not caffeine, blocks the ability of thyrotropin-releasing hormone to release Ca2+ from an intracellular store in GH4C1 pituitary cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Blockade of low and high threshold Ca2+ channels by diphenylbutylpiperidine antipsychotics linked to inhibition of prolactin gene expression.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Chloride channel blockers inhibit ACTH secretion from mouse pituitary tumor cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Thyrotropin-releasing hormone induces opposite effects on Ca2+ channel currents in pituitary cells by two pathways.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Steady-state currents through voltage-dependent, dihydropyridine-sensitive Ca2+ channels in GH3 pituitary cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Medium hyperosmolarity depresses thyrotropin-releasing hormone-induced Ca2+ influx and prolactin secretion in GH4C1 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Calcium channel agonist BAY k8644 enhances anterior pituitary secretion in rat and monkey.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1985 |
Stimulation of adrenocorticotropin secretion from AtT-20 cells by the calcium channel activator, BAY-K-8644, and its inhibition by somatostatin and carbachol.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1985 |
Interaction of dihydropyridine Ca2+ agonist Bay K 8644 with normal and transformed pituitary cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1986 |
BAY-K-8644-stimulated cyclic GMP synthesis in mouse pituitary tumor cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1986 |
Calmodulin antagonists inhibit dihydropyridine calcium channel activator (BAY-K-8644) induced cGMP synthesis in pituitary tumor cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1986 |
Dihydropyridine modulators of voltage-sensitive Ca2+ channels specifically regulate prolactin production by GH4C1 pituitary tumor cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Voltage-activated calcium channels that must be phosphorylated to respond to membrane depolarization.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Preferential role of calcium in the regulation of prolactin gene transcription by thyrotropin-releasing hormone in GH3 pituitary cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1988 |
Vitamin D-induction of secretory responses in rat pituitary tumour (GH4C1) cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1988 |
Two types of calcium channels and hormone release in human pituitary tumor cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1988 |
Prolactin synthesis in cultured pituitary cells is chloride-dependent.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1988 |
Proximal upstream flanking sequences direct calcium regulation of the rat prolactin gene.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1988 |
Thyroliberin and dihydropyridines modulate prolactin gene expression through interacting pathways in GH3 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1989 |
Characterization of voltage-sensitive calcium channels in a clonal pituitary cell line.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1985 |