bay-k-8644 has been researched along with Muscle Relaxation in 42 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The influence of deuterium oxide (D2O) on calcium-dependent vascular smooth muscle contraction was investigated." | 3.68 | Deuterium oxide reduces agonist and depolarization-induced contraction of rat aortic rings. ( Liepins, A; McWilliam, TM; Rankin, AJ, 1990) |
| "Fraxinellone and verapamil were more potent and effective in producing relaxation in 60 mmol/l than in 15 mmol/l K(+)-induced contraction." | 1.28 | Vasorelaxing effect in rat thoracic aorta caused by fraxinellone and dictamine isolated from the Chinese herb Dictamnus dasycarpus Turcz: comparison with cromakalim and Ca2+ channel blockers. ( Huang, TF; Ko, FN; Su, MJ; Teng, CM; Wang, ML; Wu, TS; Yu, SM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (23.81) | 18.7374 |
| 1990's | 24 (57.14) | 18.2507 |
| 2000's | 5 (11.90) | 29.6817 |
| 2010's | 3 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Muneer, A | 1 |
| Cellek, S | 1 |
| Ralph, DJ | 1 |
| Minhas, S | 1 |
| Lai, HH | 1 |
| Smith, CP | 1 |
| Munoz, A | 1 |
| Boone, TB | 1 |
| Szigeti, GP | 1 |
| Somogyi, GT | 1 |
| Chang, GJ | 1 |
| Lin, TP | 1 |
| Ko, YS | 1 |
| Lin, MS | 1 |
| Lee, SY | 2 |
| Lee, MY | 3 |
| Park, SH | 2 |
| Kim, TH | 1 |
| Moon, YT | 1 |
| Han, JH | 1 |
| Myung, SC | 3 |
| Fernandes, VS | 1 |
| Barahona, MV | 1 |
| Recio, P | 1 |
| Martínez-Sáenz, A | 1 |
| Ribeiro, AS | 1 |
| Contreras, C | 1 |
| Martínez, AC | 1 |
| Bustamante, S | 2 |
| Carballido, J | 1 |
| García-Sacristán, A | 1 |
| Prieto, D | 1 |
| Hernández, M | 1 |
| Keum, EM | 1 |
| Park, SY | 1 |
| Kim, SC | 2 |
| Yum, SH | 1 |
| Hirota, K | 2 |
| Zsigmond, EK | 2 |
| Matsuki, A | 2 |
| Rabito, SF | 2 |
| Okamura, H | 1 |
| Fujitani, B | 1 |
| Furukawa, K | 1 |
| Une, T | 1 |
| Nukuda, T | 1 |
| Komiya, M | 1 |
| Kurokawa, M | 1 |
| Vannier, C | 1 |
| Croxton, TL | 1 |
| Farley, LS | 1 |
| Hirshman, CA | 1 |
| Lau, WA | 1 |
| Ventura, S | 1 |
| Jiang, Q | 1 |
| Pennefather, JN | 1 |
| Nelson, MT | 1 |
| Cheng, H | 1 |
| Rubart, M | 1 |
| Santana, LF | 1 |
| Bonev, AD | 1 |
| Knot, HJ | 1 |
| Lederer, WJ | 1 |
| Kanda, M | 1 |
| Shirahase, H | 1 |
| Kurahashi, K | 1 |
| Wada, K | 1 |
| Nakamura, S | 1 |
| Matsui, H | 1 |
| Fukata, F | 1 |
| Morales, MA | 1 |
| Silva, A | 1 |
| Brito, G | 1 |
| Ponce, H | 1 |
| Paeile, C | 1 |
| Ratz, PH | 1 |
| Callahan, PE | 1 |
| Lattanzio, FA | 1 |
| Rodriguez, J | 1 |
| Garcia de Boto, MJ | 1 |
| Hidalgo, A | 1 |
| Liu, YA | 1 |
| Ostlund, E | 1 |
| Fried, G | 1 |
| Omote, M | 1 |
| Mizusawa, H | 1 |
| Sato, T | 1 |
| Lovren, F | 1 |
| O'Neill, SK | 1 |
| Bieger, D | 3 |
| Igbal, N | 1 |
| Knaus, EE | 1 |
| Triggle, CR | 4 |
| Ma, L | 1 |
| Robinson, CP | 1 |
| Thadani, U | 1 |
| Patterson, E | 1 |
| Fusi, F | 1 |
| Valoti, M | 1 |
| Petkov, GV | 1 |
| Boev, KK | 1 |
| Sgaragli, GP | 1 |
| Bell, KL | 1 |
| Kemp, BK | 1 |
| McPherson, GA | 1 |
| Hodgson, WC | 1 |
| Yang, X | 1 |
| Henson, OW | 1 |
| Bollen, BA | 1 |
| McKlveen, RE | 1 |
| Stevenson, JA | 1 |
| Yu, SM | 1 |
| Ko, FN | 1 |
| Su, MJ | 1 |
| Wu, TS | 1 |
| Wang, ML | 1 |
| Huang, TF | 1 |
| Teng, CM | 1 |
| O'Neill, S | 1 |
| Golenhofen, K | 1 |
| Finger, K | 1 |
| Förster, B | 1 |
| Mandrek, K | 1 |
| Noack, T | 1 |
| Dainty, IA | 1 |
| Bigaud, M | 1 |
| McGrath, JC | 1 |
| Spedding, M | 1 |
| McWilliam, TM | 1 |
| Liepins, A | 1 |
| Rankin, AJ | 1 |
| Adeagbo, AS | 1 |
| Dube, GP | 1 |
| Baik, YH | 1 |
| Vaghy, PL | 1 |
| Schwartz, A | 2 |
| Rubanyi, GM | 1 |
| Vanhoutte, PM | 1 |
| Matsuo, K | 2 |
| Uchida, S | 1 |
| Ebeigbe, AB | 1 |
| Aloamaka, CP | 1 |
| Kullak, A | 1 |
| Donoso, MV | 1 |
| Huidobro-Toro, JP | 1 |
| Uchida, MK | 1 |
| Godfraind, T | 1 |
| Fontaine, J | 1 |
| Lebrun, P | 1 |
| Katsoulis, S | 1 |
| Conlon, JM | 1 |
| Douglas, SA | 1 |
| Bowmer, CJ | 1 |
| Yates, MS | 1 |
1 review available for bay-k-8644 and Muscle Relaxation
| Article | Year |
|---|---|
Calcium channels in smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1988 |
41 other studies available for bay-k-8644 and Muscle Relaxation
| Article | Year |
|---|---|
The investigation of putative agents, using an in vitro model, to prevent cavernosal smooth muscle dysfunction during low-flow priapism.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2008 |
Activation of cholinergic receptors blocks non-adrenergic non-cholinergic contractions in the rat urinary bladder.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2008 |
Endothelium-dependent and -independent vasorelaxation induced by CIJ-3-2F, a novel benzyl-furoquinoline with antiarrhythmic action, in rat aorta.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2010 |
NS-398 (a selective cyclooxygenase-2 inhibitor) decreases agonist-induced contraction of the human ureter via calcium channel inhibition.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2010 |
Mechanisms involved in testosterone-induced relaxation to the pig urinary bladder neck.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2012 |
Vasomotor action of insulin on the rabbit normal cavernous smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2006 |
Contractile changes of the clitoral cavernous smooth muscle in female rabbits with experimentally induced overactive bladder.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2008 |
Ketamine inhibits contractile responses of intestinal smooth muscle by decreasing the influx of calcium through the L-type calcium channel.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Pharmacologic properties of a novel Ca2+ entry blocker, AJ-2615, in vitro.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Inhibition of dihydropyridine-sensitive calcium entry in hypoxic relaxation of airway smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Endothelin-induced facilitation of sympathetic neurotransmission to the rat vas deferens: effects of suramin.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Relaxation of arterial smooth muscle by calcium sparks.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Effects of the novel water-soluble calcium antagonist (+/-)-3-(4-allyl-1-piperazinyl)-2,2-dimethylpropyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate dihydrochloride on the responses of isolated canine arteries.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Vasorelaxant effect of the analgesic clonixin on rat aorta.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Ketamine relaxes rabbit femoral arteries by reducing [Ca2+]i and phospholipase C activity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Mechanisms involved in the relaxant effect of estrogens on rat aorta strips.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1996 |
Endothelin-induced contractions in human placental blood vessels are enhanced in intrauterine growth retardation, and modulated by agents that regulate levels of intracellular calcium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Rhythmic relaxations of active tension in the rabbit large arteries induced by a combination of cyclopiazonic acid and Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1996 |
Relaxant effect of ketamine and its isomers on histamine-induced contraction of tracheal smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1996 |
Nitric oxide, a possible mediator of 1,4-dihydropyridine-induced photorelaxation of vascular smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1996 |
Effect of 17-beta estradiol in the rabbit: endothelium-dependent and -independent mechanisms of vascular relaxation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Myorelaxant activity of 2-t-butyl-4-methoxyphenol (BHA) in guinea pig gastric fundus.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1998 |
The smooth muscle relaxant effects of venom from the inland taipan (Oxyuranus microlepidotus).
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Smooth muscle in the annulus fibrosus of the tympanic membrane: physiological effects on sound transmission in the gerbil.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |
Halothane relaxes preconstricted small and medium isolated porcine coronary artery segments more than isoflurane.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Vasorelaxing effect in rat thoracic aorta caused by fraxinellone and dictamine isolated from the Chinese herb Dictamnus dasycarpus Turcz: comparison with cromakalim and Ca2+ channel blockers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Role of guanylate cyclase activation in the smooth muscle actions of dihydropyridines.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Light-induced relaxation of smooth muscle after treatment with BAY K 8644 is related to release of nitric oxide.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Interactions of palmitoyl carnitine with the endothelium in rat aorta.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Can dihydropyridines enhance photorelaxation of smooth muscle by calcium-independent mechanisms?
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Deuterium oxide reduces agonist and depolarization-induced contraction of rat aortic rings.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Effects of some inorganic divalent cations and protein kinase C inhibitors on endothelium-dependent relaxation in rat isolated aorta and mesenteric arteries.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5 | 1991 |
Nitrendipine potentiates Bay k 8644-induced contraction of isolated porcine coronary artery: evidence for functionally distinct dihydropyridine receptor subtypes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1985 |
The calcium agonists Bay K 8644 and (+)202,791 stimulate the release of endothelial relaxing factor from canine femoral arteries.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1985 |
[Synergism of the calcium reversal phenomenon of potassium depolarizing in the rat uterine muscle by Bay k-8644, a calcium agonist].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1985 |
Role of endothelium in magnesium-induced relaxation of rat aorta.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Extracellular calcium dependence of the neurotensin-induced relaxation of intestinal smooth muscles: studies with calcium channel blockers and BAY K-8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Opposite effects of Bay k 8644 and nicardipine on the inhibitory effect of Ca2+ on rat myometrium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Pharmacological analysis of the effects of Bay K 8644 and organic calcium antagonists on the mouse isolated distal colon.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1988 |
Calcitonin gene-related peptides relax guinea pig and rat gastric smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1989 |
Vascular smooth muscle function in rats with acute renal failure.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1989 |