Page last updated: 2024-10-23

bay-k-8644 and Hypertension

bay-k-8644 has been researched along with Hypertension in 52 studies

3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.

Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Research Excerpts

ExcerptRelevanceReference
"The present study evaluates the response to the L-type voltage gated calcium channel agonist Bay K 8644 in two forms of experimental hypertension (mineralocorticoid- and hypertension induced by the nitric oxide synthase inhibitor N omega-nitro-L-arginine (N-Nitro arginine)) and under conditions of acute stretch."7.69Enhanced vascular responsiveness to Bay K 8644 in mineralocorticoid- and N-nitro arginine-induced hypertension. ( Finta, KM; Lloyd, MC; Storm, DS; Watts, SW; Webb, RC, 1994)
"Propofol acts as an L-type calcium channel (LTCC) antagonist to decrease peripheral resistance and initiate hypotension."5.38Role of L-type calcium channels in altered microvascular responses to propofol in hypertension. ( Brookes, ZL; Brown, NJ; Lawton, BK; Reilly, CS, 2012)
"To clarify whether the Ca2+ uptake function of the sarcoplasmic reticulum (SR) during arterial contraction is altered in hypertension, the effects of cyclopiazonic acid (CPA) and thapsigargin, which inhibit SR Ca2+-ATPase, on the contractile responses to Bay k 8644, an agonist of L-type Ca2+ channels, were compared in endothelium-denuded strips of carotid arteries from 13-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY)."3.71Ca2+ buffering function of the sarcoplasmic reticulum is increased in the carotid artery from spontaneously hypertensive rats. ( Asano, M; Nomura, Y, 2002)
"The present study evaluates the response to the L-type voltage gated calcium channel agonist Bay K 8644 in two forms of experimental hypertension (mineralocorticoid- and hypertension induced by the nitric oxide synthase inhibitor N omega-nitro-L-arginine (N-Nitro arginine)) and under conditions of acute stretch."3.69Enhanced vascular responsiveness to Bay K 8644 in mineralocorticoid- and N-nitro arginine-induced hypertension. ( Finta, KM; Lloyd, MC; Storm, DS; Watts, SW; Webb, RC, 1994)
"Propofol acts as an L-type calcium channel (LTCC) antagonist to decrease peripheral resistance and initiate hypotension."1.38Role of L-type calcium channels in altered microvascular responses to propofol in hypertension. ( Brookes, ZL; Brown, NJ; Lawton, BK; Reilly, CS, 2012)
"Bezafibrate treatment lowered blood pressure, free fatty acids, and triglycerides in the fructose-fed group, suggesting that lipid abnormalities play a role in the elevation of blood pressure in the fructose-induced hypertensive rat."1.30Bezafibrate, an anti-hypertriglyceridemic drug, attenuates vascular hyperresponsiveness and elevated blood pressure in fructose-induced hypertensive rats. ( Richey, JM; Si, X; Webb, RC, 1999)
"Treatment with ramipril reduced blood pressure and force development in response to Bay K8644 in adult SHRSP, although not to levels of WKY rats, whereas WKY rats were unaffected by treatment."1.29Angiotensin-converting enzyme inhibition during development alters calcium regulation in adult hypertensive rats. ( Traub, O; Webb, RC, 1993)
"Hydralazine treatment and sodium deprivation did not significantly modify the pressure-independence of renin release by LH rat kidneys."1.29Pressure control of renal renin release in Lyon hypertensive rats. ( Bertolino, S; Medeiros, IA; Sassard, J; Zhang, BL, 1994)
"Nifedipine was less efficacious in relaxing the contractile response to Bay k 8644 compared to the contractile response to K+ in SHRs femoral arteries."1.27Contractile effects of Bay k 8644, a dihydropyridine calcium agonist, on isolated femoral arteries from spontaneously hypertensive rats. ( Aoki, K; Asano, M; Matsuda, T, 1986)

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-19909 (17.31)18.7374
1990's34 (65.38)18.2507
2000's5 (9.62)29.6817
2010's3 (5.77)24.3611
2020's1 (1.92)2.80

Authors

AuthorsStudies
Vo, D1
Matowe, WC1
Ramesh, M1
Iqbal, N1
Wolowyk, MW1
Howlett, SE1
Knaus, EE1
Lin, YK1
Chen, YJ1
Li, JY1
Chen, YL1
He, D1
Zuo, R1
Xiao, MJ1
Xu, DP1
Zheng, CY1
Wang, W1
He, RR1
Chen, Y1
Lloyd, EE1
Crossland, RF1
Phillips, SC1
Marrelli, SP1
Reddy, AK1
Taffet, GE1
Hartley, CJ1
Bryan, RM1
Grześk, G1
Wiciński, M1
Malinowski, B1
Grześk, E1
Manysiak, S1
Odrowąż-Sypniewska, G1
Darvish, N1
Bierwagen, M1
Lawton, BK1
Brown, NJ1
Reilly, CS1
Brookes, ZL1
David, FL1
Montezano, AC1
Rebouças, NA1
Nigro, D1
Fortes, ZB1
Carvalho, MH1
Tostes, RC3
Garthoff, B1
Kazda, S1
Luckhaus, G1
Asano, M6
Nomura, Y4
Ito, K1
Uyama, Y1
Imaizumi, Y1
Watanabe, M1
Traub, O2
Webb, RC8
Lal, KJ1
Dakshinamurti, K1
Wilde, DW2
Furspan, PB1
Szocik, JF1
Medeiros, IA1
Zhang, BL1
Bertolino, S1
Sassard, J1
Watts, SW2
Finta, KM1
Lloyd, MC1
Storm, DS3
Hérembert, T1
Zhu, DL1
Marche, P1
Ribeiro, MO1
Antunes, E1
Muscará, MN1
De Nucci, G1
Zatz, R1
Mertens, MJ1
Pfaffendorf, M2
Van Zwieten, PA2
Huguet, F1
Brisac, AM2
Dubar, M1
Ingrand, P1
Piriou, A1
Hui, C2
Goto, A2
Yamada, K2
Yagi, N2
Nagoshi, H2
Sasabe, M2
Omata, M2
Hernández, MC1
Salaices, M2
Ponte, A1
Alonso, MJ1
Sánchez-Ferrer, CF1
Marín, J2
Beenen, OH1
Tsuda, K2
Tsuda, S2
Nishio, I1
Masuyama, Y2
Goldstein, M2
Bendhack, LM1
McConnell, BK1
Moravec, CS1
Morano, I1
Bond, M1
Le Roy, AL1
Messer-Létienne, I1
Bernard, N1
Benzoni, D1
Ren, J3
Brown, RA3
Sugimoto, T1
Jefferson, L2
Sudan, N1
Lloyd, TC1
Manso, AM1
Encabo, A1
Ferrer, M1
Balfagón, G1
Si, X1
Richey, JM1
Sowers, JR1
Chi, DH1
Mukundan, H1
Kanagy, NL1
Kamata, K1
Miyata, N1
Kasuya, Y1
Boonen, HC1
De Mey, JG1
Jubelin, BC1
Kannan, MS1
Turla, MB1
Todd, KM1
Bruner, CA1
Yu, Z1
McNeill, JH1
Takeshita, H1
Nishikibe, M1
Yano, M1
Ikemoto, F1
Docherty, JR2
Warnock, P2
Aoki, K2
Matsuda, T1
Steele, TH2
Challoner-Hue, L1
Lacolley, P1
Laurent, S1
Tsoucaris-Kupfer, D1
Legrand, M1
Schmitt, H1
Bolzon, BJ1
Cheung, DW1

Reviews

2 reviews available for bay-k-8644 and Hypertension

ArticleYear
Calcium handling by vascular myocytes in hypertension.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1997, Volume: 30, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1997
Calcium entry modulation and renal hemodynamics in the hypertensive kidney.
    American journal of nephrology, 1987, Volume: 7 Suppl 1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1987

Other Studies

50 other studies available for bay-k-8644 and Hypertension

ArticleYear
Syntheses, calcium channel agonist-antagonist modulation activities, and voltage-clamp studies of isopropyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-pyridinylpyridine-5-carboxylate racemates and enantiomers.
    Journal of medicinal chemistry, 1995, Jul-21, Volume: 38, Issue:15

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1995
Salvianolic acid A from Danhong Injection induces vasorelaxation by Regulating L-type calcium channel in isolated mouse arteries.
    Journal of ethnopharmacology, 2022, Oct-05, Volume: 296

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2022
Disruption of K(2P)6.1 produces vascular dysfunction and hypertension in mice.
    Hypertension (Dallas, Tex. : 1979), 2011, Volume: 58, Issue:4

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Pyridinecarboxylic acid, 1,4-d

2011
Calcium blockers inhibit cyclosporine A-induced hyperreactivity of vascular smooth muscle cells.
    Molecular medicine reports, 2012, Volume: 5, Issue:6

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2012
Role of L-type calcium channels in altered microvascular responses to propofol in hypertension.
    British journal of anaesthesia, 2012, Volume: 108, Issue:6

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2012
Gender differences in vascular expression of endothelin and ET(A)/ET(B) receptors, but not in calcium handling mechanisms, in deoxycorticosterone acetate-salt hypertension.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2002, Volume: 35, Issue:9

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2002
'Calcium agonist' in salt-dependent hypertension: hints at calcium-mediated blood pressure increase.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1984, Volume: 2, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1984
Increased function of voltage-dependent Ca++ channels and Ca(++)-activated K+ channels in resting state of femoral arteries from spontaneously hypertensive rats at prehypertensive stage.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1995
Angiotensin-converting enzyme inhibition during development alters calcium regulation in adult hypertensive rats.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1993
Calcium channels in vitamin B6 deficiency-induced hypertension.
    Journal of hypertension, 1993, Volume: 11, Issue:12

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1993
Calcium current in smooth muscle cells from normotensive and genetically hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 1994, Volume: 24, Issue:6

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1994
Pressure control of renal renin release in Lyon hypertensive rats.
    Journal of hypertension, 1994, Volume: 12, Issue:8

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1994
Effects of ramipril on contractile oscillations in arteries from genetically hypertensive rats.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 1994, Volume: 16, Issue:6

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1994
Enhanced vascular responsiveness to Bay K 8644 in mineralocorticoid- and N-nitro arginine-induced hypertension.
    Blood pressure, 1994, Volume: 3, Issue:5

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1994
Mechanism of action of the inhibitory effect of nifedipine on the growth of cultured aortic cells from spontaneously hypertensive and normotensive rats.
    British journal of pharmacology, 1995, Volume: 114, Issue:8

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1995
Nifedipine prevents renal injury in rats with chronic nitric oxide inhibition.
    Hypertension (Dallas, Tex. : 1979), 1995, Volume: 26, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Pyridinecarboxylic acid, 1,4-d

1995
Sensitivity of cardiac tissues with moderate and advanced hypertrophy to calcium ions.
    General pharmacology, 1995, Volume: 26, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1995
Endothelin modulates dihydropyridine receptor decreased binding in hippocampal slices from normotensive and spontaneously hypertensive rats.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1993, Volume: 11, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1993
Modulation of vascular calcium channel activity in response to acute volume expansion in rats.
    Life sciences, 1996, Volume: 58, Issue:4

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1996
Effects of Bay K 8644 in aorta from spontaneously hypertensive and Wistar Kyoto rats of different ages.
    Journal of autonomic pharmacology, 1995, Volume: 15, Issue:4

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1995
Contractile responses to various inotropic agents in isolated hearts obtained from hypertensive diabetic rats.
    Blood pressure, 1995, Volume: 4, Issue:6

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1995
Synergistic effects of Bay K 8644 and bradykinin on norepinephrine release in the hypothalamus of spontaneously hypertensive rats.
    Clinical and experimental pharmacology & physiology. Supplement, 1995, Volume: 22, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1995
Troponin I phosphorylation in spontaneously hypertensive rat heart: effect of beta-adrenergic stimulation.
    The American journal of physiology, 1997, Volume: 273, Issue:3 Pt 2

    Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifl

1997
Effects of L-type calcium channel activation on renal vascular resistances in the Lyon hypertensive rat.
    Journal of cardiovascular pharmacology, 1999, Volume: 33, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1999
Hypertension augments ethanol-induced depression of cell shortening and intracellular Ca(2+) transients in adult rat ventricular myocytes.
    Biochemical and biophysical research communications, 1999, Jul-22, Volume: 261, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1999
Relations of vascular calcium channels with blood pressure and endothelium in hypertension and with aging.
    Japanese heart journal, 1999, Volume: 40, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1999
Acetaldehyde depresses myocardial contraction and cardiac myocyte shortening in spontaneously hypertensive rats: role of intracellular Ca2+.
    Cellular and molecular biology (Noisy-le-Grand, France), 1999, Volume: 45, Issue:4

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1999
Changes of cardiac calcium homeostasis in spontaneously hypertensive rats.
    Journal of autonomic pharmacology, 1999, Volume: 19, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1999
Bezafibrate, an anti-hypertriglyceridemic drug, attenuates vascular hyperresponsiveness and elevated blood pressure in fructose-induced hypertensive rats.
    Canadian journal of physiology and pharmacology, 1999, Volume: 77, Issue:10

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1999
Influence of age on contractile response to insulin-like growth factor 1 in ventricular myocytes from spontaneously hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 1999, Volume: 34, Issue:6

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1999
Intracellular calcium stores and oscillatory contractions in arteries from genetically hypertensive rats.
    Hypertension research : official journal of the Japanese Society of Hypertension, 1996, Volume: 19, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1996
Calcium buffering of resting, voltage-dependent Ca2+ influx by sarcoplasmic reticulum in femoral arteries from spontaneously hypertensive rats at prehypertensive stage.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2001, Volume: 24, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2001
Ca2+ influx mediates enhanced alpha2-adrenergic contraction in aortas from rats treated with NOS inhibitor.
    American journal of physiology. Heart and circulatory physiology, 2001, Volume: 281, Issue:5

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2001
Ca2+ buffering function of the sarcoplasmic reticulum is increased in the carotid artery from spontaneously hypertensive rats.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2002, Volume: 25, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2002
Increased Ca2+ buffering function of sarcoplasmic reticulum in small mesenteric arteries from spontaneously hypertensive rats.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2002, Volume: 25, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2002
Effects of endothelin on the portal vein from spontaneously hypertensive and Wistar Kyoto rats.
    General pharmacology, 1990, Volume: 21, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1990
Increased calcium sensitivity in isolated resistance arteries from spontaneously hypertensive rats: effects of dihydropyridines.
    European journal of pharmacology, 1990, Apr-25, Volume: 179, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1990
Neurons from neonatal hypertensive rats exhibit abnormal membrane properties in vitro.
    The American journal of physiology, 1990, Volume: 259, Issue:3 Pt 1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1990
Calcium and contractile responses to phorbol esters and the calcium channel agonist, Bay K 8644, in arteries from hypertensive rats.
    American journal of hypertension, 1990, Volume: 3, Issue:8 Pt 2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1990
Increased vascular reactivity to Bay K 8644 in genetic hypertension.
    Pharmacology, 1990, Volume: 41, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1990
Altered inotropic responses in diabetic cardiomyopathy and hypertensive-diabetic cardiomyopathy.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1991
Effects of Bay K 8644, a Ca2+ channel agonist, on [3H]norepinephrine release in hypothalamus of spontaneously hypertensive rats.
    European journal of pharmacology, 1991, Feb-26, Volume: 194, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1991
Coronary vascular response to endothelin in isolated perfused hearts of spontaneously hypertensive rats.
    Clinical and experimental pharmacology & physiology, 1991, Volume: 18, Issue:9

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1991
An investigation of alpha-adrenoceptor responsiveness in the vas deferens of spontaneously hypertensive rats.
    British journal of pharmacology, 1985, Volume: 86, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1985
Effects of Bay K 8644 and nifedipine on femoral arteries of spontaneously hypertensive rats.
    British journal of pharmacology, 1986, Volume: 88, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1986
Contractile effects of Bay k 8644, a dihydropyridine calcium agonist, on isolated femoral arteries from spontaneously hypertensive rats.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1986
Reduced alpha 1-adrenoreceptor mediated responsiveness in vas deferens from spontaneously hypertensive rats.
    Journal of autonomic pharmacology, 1986, Volume: 6, Issue:4

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1986
Exaggerated Dahl salt-sensitive kidney response to calcium channel agonist isomer of Bay k 8644, but not to calcium channel antagonist isomer of Bay k 8644.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1986, Volume: 4, Issue:5

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1986
[Central control of the baroreflex response to phenylephrine by dihydropyridines in the anesthetized rat].
    Archives des maladies du coeur et des vaisseaux, 1988, Volume: 81 Spec No

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1988
Isolation and characterization of single vascular smooth muscle cells from spontaneously hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 1989, Volume: 14, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1989