bay-k-8644 has been researched along with Heart Failure in 9 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moltzau, LR | 1 |
| Aronsen, JM | 1 |
| Meier, S | 1 |
| Nguyen, CH | 1 |
| Hougen, K | 1 |
| Ørstavik, Ø | 1 |
| Sjaastad, I | 1 |
| Christensen, G | 1 |
| Skomedal, T | 1 |
| Osnes, JB | 1 |
| Levy, FO | 1 |
| Qvigstad, E | 1 |
| Kashihara, T | 1 |
| Nakada, T | 1 |
| Shimojo, H | 1 |
| Horiuchi-Hirose, M | 1 |
| Gomi, S | 1 |
| Shibazaki, T | 1 |
| Sheng, X | 1 |
| Hirose, M | 1 |
| Hongo, M | 1 |
| Yamada, M | 1 |
| Kamp, TJ | 1 |
| He, JQ | 1 |
| Chen, X | 2 |
| Piacentino, V | 3 |
| Furukawa, S | 1 |
| Goldman, B | 1 |
| Margulies, KB | 2 |
| Houser, SR | 3 |
| Zhang, X | 1 |
| Harris, DM | 1 |
| Berretta, RM | 1 |
| Ruf, T | 1 |
| Hebisch, S | 1 |
| Gross, R | 1 |
| Alpert, N | 1 |
| Just, H | 1 |
| Holubarsch, C | 1 |
| Kim, CS | 1 |
| Davidoff, AJ | 1 |
| Maki, TM | 1 |
| Doye, AA | 1 |
| Gwathmey, JK | 1 |
| Gaughan, JP | 1 |
| Colucci, WS | 1 |
| Wright, RF | 1 |
| Braunwald, E | 1 |
1 review available for bay-k-8644 and Heart Failure
| Article | Year |
|---|---|
New positive inotropic agents in the treatment of congestive heart failure. Mechanisms of action and recent clinical developments. 2.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1986 |
8 other studies available for bay-k-8644 and Heart Failure
| Article | Year |
|---|---|
SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2013 |
Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca²⁺ channel activity through phosphatases in heart failure.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2012 |
L-type Ca2+ channels gaining respect in heart failure.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |
L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |
Reduced effects of BAY K 8644 on L-type Ca2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2008 |
Modulation of myocardial economy and efficiency in mammalian failing and non-failing myocardium by calcium channel activation and beta-adrenergic stimulation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1996 |
Intracellular calcium and the relationship to contractility in an avian model of heart failure.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2000 |
L-type Ca(2+) currents overlapping threshold Na(+) currents: could they be responsible for the "slip-mode" phenomenon in cardiac myocytes?
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |