bay-k-8644 has been researched along with Heart Disease, Ischemic in 7 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Effects of verapamil on arrhythmias induced by Bay K8644 (a calcium channel agonist) were also determined." | 1.39 | Anti-arrhythmic effect of verapamil is accompanied by preservation of cx43 protein in rat heart. ( Chen, M; Pei, JM; Wang, QL; Wu, Q; Zhang, SM; Zhou, P, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (85.71) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, P | 1 |
| Zhang, SM | 1 |
| Wang, QL | 1 |
| Wu, Q | 1 |
| Chen, M | 1 |
| Pei, JM | 1 |
| Guppy, LJ | 2 |
| Littleton, JM | 2 |
| Rump, AF | 1 |
| Rösen, R | 1 |
| Sigmund, B | 1 |
| Fuchs, J | 1 |
| Ratke, R | 1 |
| Klaus, W | 1 |
| Kumar, R | 1 |
| Joyner, RW | 1 |
| Miyawaki, H | 1 |
| Ashraf, M | 1 |
| Smart, SC | 1 |
| Sagar, KB | 1 |
| Warltier, DC | 1 |
7 other studies available for bay-k-8644 and Heart Disease, Ischemic
| Article | Year |
|---|---|
Anti-arrhythmic effect of verapamil is accompanied by preservation of cx43 protein in rat heart.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2013 |
Partial left ventricular ischemia in isolated hearts obtained from ethanol-dependent rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Influence of dihydropyridine-type calcium agonists on hemodynamics and myocardial ischemia in isolated rabbit hearts.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
An experimental model of the production of early after depolarizations by injury current from an ischemic region.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Isoproterenol mimics calcium preconditioning-induced protection against ischemia.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Differential roles of myocardial Ca2+ channels and Na+/Ca2+ exchange in myocardial reperfusion injury in open chest dogs: relative roles during ischemia and reperfusion.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Effect of calcium, Bay K 8644, and reduced perfusion on basic indices of myocardial function in isolated hearts from rats after prolonged exposure to ethanol.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |