bay-k-8644 has been researched along with Dystonia in 7 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Systemic administration of the L-type calcium channel agonists +/-Bay K 8644 or FPL 64176 causes a characteristic pattern of motor dysfunction in normal C57BL/6J mice that resembles generalized dystonia." | 3.70 | Calcium channel agonists and dystonia in the mouse. ( Drew, T; Hess, EJ; Ho, T; Jinnah, HA; Rothstein, JD; Sepkuty, JP; Yitta, S, 2000) |
| "AMPA receptor agonists induced dystonia, and AMPA receptor antagonists reduced the dystonia induced by glutamate receptor agonists." | 1.38 | Selective and sustained α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor activation in cerebellum induces dystonia in mice. ( Fan, X; Hess, EJ; Hughes, KE; Jinnah, HA, 2012) |
| "Nimodipine was more potent in this respect and did not cause any behavioral side effects." | 1.29 | Antidystonic effects of L-type Ca2+ channel antagonists in a hamster model of idiopathic dystonia. ( Löscher, W; Richter, A, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fan, X | 2 |
| Hughes, KE | 1 |
| Jinnah, HA | 4 |
| Hess, EJ | 4 |
| Saika, E | 1 |
| Miyamoto, Y | 1 |
| Hibi, Y | 1 |
| Muramatsu, S | 1 |
| Nabeshima, T | 1 |
| Nitta, A | 1 |
| Kasim, S | 2 |
| Blake, BL | 1 |
| Chartoff, E | 1 |
| Egami, K | 1 |
| Breese, GR | 1 |
| Richter, A | 1 |
| Löscher, W | 1 |
| Campbell, DB | 1 |
| Sepkuty, JP | 1 |
| Ho, T | 1 |
| Yitta, S | 1 |
| Drew, T | 1 |
| Rothstein, JD | 1 |
7 other studies available for bay-k-8644 and Dystonia
| Article | Year |
|---|---|
Selective and sustained α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor activation in cerebellum induces dystonia in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2012 |
[JSNP Excellent Presentation Award for AsCNP 2011: role of a novel molecule "shati" in animal model of dystonia].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2012 |
Pharmacologic thresholds for self-injurious behavior in a genetic mouse model of Lesch-Nyhan disease.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |
The role of dopamine receptors in the neurobehavioral syndrome provoked by activation of L-type calcium channels in rodents.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2006 |
Antidystonic effects of L-type Ca2+ channel antagonists in a hamster model of idiopathic dystonia.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1996 |
L-type calcium channels contribute to the tottering mouse dystonic episodes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Calcium channel agonists and dystonia in the mouse.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2000 |