bay-k-8644 has been researched along with Disease Models, Animal in 37 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
Excerpt | Relevance | Reference |
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" Ranolazine is an antianginal agent shown to exert an antiarrhythmic effect in experimental models of long QT syndrome." | 3.74 | Cellular basis for the electrocardiographic and arrhythmic manifestations of Timothy syndrome: effects of ranolazine. ( Antzelevitch, C; Belardinelli, L; Glass, A; Goodrow, RJ; Sicouri, S; Timothy, KW; Zygmunt, AC, 2007) |
" Localized inflammation was induced via injection of inflammatory agents lambda-carrageenan (CA) or histamine into rat hindpaws, alone or in conjunction with pharmacological agents, resulting in a spatially and temporally defined inflammatory reaction." | 3.74 | Acute exposure to a moderate strength static magnetic field reduces edema formation in rats. ( Morris, CE; Skalak, TC, 2008) |
"We report the effects of two new dihydropyridine derivatives, isradipine (4-(4'-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedic arboxylic acid methylisopropylester) and niguldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride), and of dantrolene (1-[(5-[p-nitrophenyl]furfurylidene)-amino]hydantoin sodium, an inhibitor of Ca2+ release from intracellular stores) on the protective efficacy of antiepileptic drugs against maximal electroshock-induced seizures." | 3.69 | Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice. ( Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1997) |
"We measured left ventricular monophasic action potentials in normal dogs and dogs with left ventricular hypertrophy before and after administration of the calcium agonist BAY K 8644 and the potassium channel blocker cesium." | 3.68 | Canine left ventricular hypertrophy predisposes to ventricular tachycardia induction by phase 2 early afterdepolarizations after administration of BAY K 8644. ( Ayers, GM; Ben-David, J; Pride, HP; Zipes, DP, 1992) |
"Cardiac arrhythmias associated with intracellular calcium inhomeostasis are refractory to antiarrhythmic therapy." | 1.46 | Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions. ( Chu, YP; Ding, YS; Huang, SH; Huo, Y; Ren, L; Wang, P; Wei, XH; Wu, L; Yang, QM; Yang, W; Yu, SD, 2017) |
"Effects of verapamil on arrhythmias induced by Bay K8644 (a calcium channel agonist) were also determined." | 1.39 | Anti-arrhythmic effect of verapamil is accompanied by preservation of cx43 protein in rat heart. ( Chen, M; Pei, JM; Wang, QL; Wu, Q; Zhang, SM; Zhou, P, 2013) |
"The results showed that the arrhythmia score was significantly higher in the SGIR group as compared with the NC and NCEA groups." | 1.35 | Antiarrhythmic effect of acupuncture pretreatment in rats subjected to simulative global ischemia and reperfusion--involvement of adenylate cyclase, protein kinase A, and L-type Ca2+ channel. ( Cui, H; Fu, W; Gao, J; Lu, B; Wang, H; Wang, Y; Yu, X; Yu, Y; Zhang, L, 2008) |
" The dose-response curve of insulin secretion showed a markedly reduced maximum response, but almost normal glucose sensitivity in NSY islets." | 1.31 | Insulin secretion to glucose as well as nonglucose stimuli is impaired in spontaneously diabetic Nagoya-Shibata-Yasuda mice. ( Babaya, N; Hamada, Y; Ikegami, H; Kawaguchi, Y; Nojima, K; Ogihara, T; Shibata, M; Ueda, H; Yamada, K; Yamato, E, 2001) |
"The ventricular arrhythmia torsade de pointes (TdP) occurs after QT interval prolongation and is associated with sudden cardiac death." | 1.30 | Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits. ( Anderson, ME; Mazur, A; Roden, DM, 1999) |
"Treatment with ramipril reduced blood pressure and force development in response to Bay K8644 in adult SHRSP, although not to levels of WKY rats, whereas WKY rats were unaffected by treatment." | 1.29 | Angiotensin-converting enzyme inhibition during development alters calcium regulation in adult hypertensive rats. ( Traub, O; Webb, RC, 1993) |
"Septic shock is characterized by a decreased vascular tone and a depressed myocardial function." | 1.28 | Administration of the calcium agonist BAY K 8644 in endotoxic shock. ( Cosyns, B; Moulart, D; Preiser, JC; Vincent, JL, 1991) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (5.41) | 18.7374 |
1990's | 8 (21.62) | 18.2507 |
2000's | 16 (43.24) | 29.6817 |
2010's | 9 (24.32) | 24.3611 |
2020's | 2 (5.41) | 2.80 |
Authors | Studies |
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Solinski, HJ | 1 |
Dranchak, P | 1 |
Oliphant, E | 1 |
Gu, X | 1 |
Earnest, TW | 1 |
Braisted, J | 1 |
Inglese, J | 1 |
Hoon, MA | 1 |
Abrams, RPM | 1 |
Yasgar, A | 1 |
Teramoto, T | 1 |
Lee, MH | 1 |
Dorjsuren, D | 1 |
Eastman, RT | 1 |
Malik, N | 1 |
Zakharov, AV | 1 |
Li, W | 1 |
Bachani, M | 1 |
Brimacombe, K | 1 |
Steiner, JP | 1 |
Hall, MD | 1 |
Balasubramanian, A | 1 |
Jadhav, A | 1 |
Padmanabhan, R | 1 |
Simeonov, A | 1 |
Nath, A | 1 |
Sestito, LF | 1 |
To, KHT | 1 |
Cribb, MT | 1 |
Archer, PA | 1 |
Thomas, SN | 1 |
Dixon, JB | 1 |
Wei, XH | 1 |
Yu, SD | 1 |
Ren, L | 1 |
Huang, SH | 1 |
Yang, QM | 1 |
Wang, P | 1 |
Chu, YP | 1 |
Yang, W | 1 |
Ding, YS | 1 |
Huo, Y | 1 |
Wu, L | 1 |
Fan, J | 1 |
Fan, W | 1 |
Lei, J | 1 |
Zhou, Y | 1 |
Xu, H | 1 |
Kapoor, I | 1 |
Zhu, G | 1 |
Wang, J | 1 |
Bai, Y | 1 |
Jones, PP | 1 |
Guo, J | 1 |
Zhong, X | 1 |
Clark, RB | 1 |
Zhou, Q | 1 |
Wang, R | 1 |
Vallmitjana, A | 1 |
Benitez, R | 1 |
Hove-Madsen, L | 1 |
Semeniuk, L | 1 |
Guo, A | 1 |
Song, LS | 1 |
Duff, HJ | 1 |
Chen, SR | 1 |
Zhou, P | 1 |
Zhang, SM | 1 |
Wang, QL | 1 |
Wu, Q | 1 |
Chen, M | 1 |
Pei, JM | 1 |
Gao, J | 1 |
Zhang, L | 1 |
Wang, Y | 1 |
Lu, B | 1 |
Cui, H | 1 |
Fu, W | 1 |
Wang, H | 1 |
Yu, Y | 1 |
Yu, X | 1 |
Turner, CP | 1 |
Debenedetto, D | 1 |
Liu, C | 1 |
Kamata, K | 1 |
Ozawa, Y | 1 |
Kobayashi, T | 1 |
Matsumoto, T | 1 |
Borbouse, L | 1 |
Dick, GM | 1 |
Asano, S | 1 |
Bender, SB | 1 |
Dincer, UD | 1 |
Payne, GA | 1 |
Neeb, ZP | 1 |
Bratz, IN | 1 |
Sturek, M | 1 |
Tune, JD | 1 |
Lloyd, EE | 1 |
Crossland, RF | 1 |
Phillips, SC | 1 |
Marrelli, SP | 1 |
Reddy, AK | 1 |
Taffet, GE | 1 |
Hartley, CJ | 1 |
Bryan, RM | 1 |
Devine, DP | 2 |
Lü, N | 1 |
Cheng, LZ | 1 |
Zhang, YQ | 1 |
Lü, BC | 1 |
Li, YQ | 1 |
Zhao, ZQ | 1 |
Saika, E | 1 |
Miyamoto, Y | 1 |
Hibi, Y | 1 |
Muramatsu, S | 1 |
Nabeshima, T | 1 |
Nitta, A | 1 |
Unlu, A | 1 |
Hariharan, N | 1 |
Iskandar, BJ | 1 |
Yaris, E | 1 |
Kesim, M | 1 |
Kadioglu, M | 1 |
Kalyoncu, NI | 1 |
Ulku, C | 1 |
Ozyavuz, R | 1 |
Forrest, A | 1 |
Molleman, A | 1 |
Parsons, M | 1 |
Kasim, S | 1 |
Blake, BL | 2 |
Fan, X | 1 |
Chartoff, E | 1 |
Egami, K | 2 |
Breese, GR | 2 |
Hess, EJ | 1 |
Jinnah, HA | 2 |
Muehlmann, AM | 1 |
Sicouri, S | 1 |
Timothy, KW | 1 |
Zygmunt, AC | 1 |
Glass, A | 1 |
Goodrow, RJ | 1 |
Belardinelli, L | 1 |
Antzelevitch, C | 1 |
Morris, CE | 1 |
Skalak, TC | 1 |
Traub, O | 1 |
Webb, RC | 1 |
Ito, A | 1 |
Shimokawa, H | 2 |
Nakaike, R | 1 |
Fukai, T | 1 |
Sakata, M | 1 |
Takayanagi, T | 1 |
Egashira, K | 2 |
Takeshita, A | 2 |
Borowicz, KK | 1 |
Gasior, M | 1 |
Kleinrok, Z | 1 |
Czuczwar, SJ | 1 |
Hui, C | 1 |
Goto, A | 1 |
Yamada, K | 2 |
Yagi, N | 1 |
Nagoshi, H | 1 |
Sasabe, M | 1 |
Omata, M | 1 |
Sugimoto, T | 1 |
Mazur, A | 1 |
Roden, DM | 1 |
Anderson, ME | 1 |
Kuga, T | 1 |
Hirakawa, Y | 1 |
Kadokami, Y | 1 |
Arai, Y | 1 |
Fukumoto, Y | 1 |
Kuwata, K | 1 |
Kozai, T | 1 |
Zavecz, JH | 1 |
Bueno, O | 1 |
Maloney, RE | 1 |
O'Donnell, JM | 1 |
Roerig, SC | 1 |
Battarbee, HD | 1 |
Kim, CS | 1 |
Davidoff, AJ | 1 |
Maki, TM | 1 |
Doye, AA | 1 |
Gwathmey, JK | 1 |
Hamada, Y | 1 |
Ikegami, H | 1 |
Ueda, H | 1 |
Kawaguchi, Y | 1 |
Yamato, E | 1 |
Nojima, K | 1 |
Babaya, N | 1 |
Shibata, M | 1 |
Ogihara, T | 1 |
Sadeghi, A | 1 |
Doyle, AD | 1 |
Johnson, BD | 1 |
Ben-David, J | 1 |
Zipes, DP | 1 |
Ayers, GM | 1 |
Pride, HP | 1 |
Preiser, JC | 1 |
Moulart, D | 1 |
Cosyns, B | 1 |
Vincent, JL | 1 |
Belis, JA | 1 |
Curley, RM | 1 |
Wagner, CH | 1 |
Murty, VN | 1 |
Winter, SJ | 1 |
Rohner, TJ | 1 |
Pellegrini-Giampietro, DE | 1 |
Bacciottini, L | 1 |
Carlà, V | 1 |
Moroni, F | 1 |
Undrovinas, AI | 1 |
January, C | 1 |
Iuriavichus, I | 1 |
Riddle, J | 1 |
Zablotskaĭte, D | 1 |
37 other studies available for bay-k-8644 and Disease Models, Animal
Article | Year |
---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Lymphatic-draining nanoparticles deliver Bay K8644 payload to lymphatic vessels and enhance their pumping function.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2023 |
Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2017 |
Galectin-1 attenuates cardiomyocyte hypertrophy through splice-variant specific modulation of Ca
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2019 |
Phospholamban knockout breaks arrhythmogenic Ca²⁺ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2013 |
Anti-arrhythmic effect of verapamil is accompanied by preservation of cx43 protein in rat heart.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2013 |
Antiarrhythmic effect of acupuncture pretreatment in rats subjected to simulative global ischemia and reperfusion--involvement of adenylate cyclase, protein kinase A, and L-type Ca2+ channel.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2008 |
NMDAR blockade-induced neonatal brain injury: Reversal by the calcium channel agonist BayK 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2009 |
Effect of N-epsilon-(carboxymethyl)lysine on coronary vasoconstriction in isolated perfused hearts from control and streptozotocin-induced diabetic rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2009 |
Impaired function of coronary BK(Ca) channels in metabolic syndrome.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 2-Chloroadenosine; 3-Pyridinecar | 2009 |
Disruption of K(2P)6.1 produces vascular dysfunction and hypertension in mice.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Pyridinecarboxylic acid, 1,4-d | 2011 |
Animal models of self-injurious behaviour: an overview.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2012 |
Involvement of ryanodine receptors in tetanic sciatic stimulation-induced long-term potentiation of spinal dorsal horn and persistent pain in rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2012 |
[JSNP Excellent Presentation Award for AsCNP 2011: role of a novel molecule "shati" in animal model of dystonia].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2012 |
Spinal cord regeneration induced by a voltage-gated calcium channel agonist.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |
The effects of paroxetine on rat isolated vas deferens.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2003 |
The responses to manipulation of extracellular and intracellular calcium are altered in the streptozotocin-diabetic rat colon and ileum.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2005 |
The role of dopamine receptors in the neurobehavioral syndrome provoked by activation of L-type calcium channels in rodents.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2006 |
Nifedipine suppresses self-injurious behaviors in animals.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2007 |
Cellular basis for the electrocardiographic and arrhythmic manifestations of Timothy syndrome: effects of ranolazine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2007 |
Acute exposure to a moderate strength static magnetic field reduces edema formation in rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2008 |
Angiotensin-converting enzyme inhibition during development alters calcium regulation in adult hypertensive rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Role of protein kinase C-mediated pathway in the pathogenesis of coronary artery spasm in a swine model.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Relations of vascular calcium channels with blood pressure and endothelium in hypertension and with aging.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Increased expression of L-type calcium channels in vascular smooth muscle cells at spastic site in a porcine model of coronary artery spasm.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2000 |
Cardiac excitation-contraction coupling in the portal hypertensive rat.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2000 |
Intracellular calcium and the relationship to contractility in an avian model of heart failure.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2000 |
Insulin secretion to glucose as well as nonglucose stimuli is impaired in spontaneously diabetic Nagoya-Shibata-Yasuda mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2001 |
Regulation of the cardiac L-type Ca2+ channel by the actin-binding proteins alpha-actinin and dystrophin.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |
Canine left ventricular hypertrophy predisposes to ventricular tachycardia induction by phase 2 early afterdepolarizations after administration of BAY K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Administration of the calcium agonist BAY K 8644 in endotoxic shock.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Neurogenic function of the diabetic rat bladder: alteration by calcium channel effectors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Morphine withdrawal in cortical slices: suppression by Ca2+-channel inhibitors of abstinence-induced [3H]-noradrenaline release.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1988 |
[Asymmetrical changes in electrical activity of Purkinje fibers and muscle cells after administration of BAY K 8644. A new model of cardiac arrhythmia].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1989 |