bay-k-8644 has been researched along with Diabetes Mellitus in 2 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Isolated right ventricular myocardial strips were used to generate dose-response curves to isoproterenol, forskolin, and Bay K 8644." | 1.32 | Altered inotropic reactivity in diabetic rabbit right ventricular myocardium. ( Lee, JR; Lin, BK; Reigel, CE; Tenner, TE; Zhang, XJ, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Menhaji-Klotz, E | 1 |
| Price, DA | 1 |
| Lee, JR | 1 |
| Zhang, XJ | 1 |
| Lin, BK | 1 |
| Reigel, CE | 1 |
| Tenner, TE | 1 |
1 review available for bay-k-8644 and Diabetes Mellitus
| Article | Year |
|---|---|
Small molecules that promote regenerative repair for pancreatic and cardiovascular health.
Topics: Cardiovascular Diseases; Cardiovascular System; Diabetes Mellitus; Drug Delivery Systems; Humans; Me | 2015 |
1 other study available for bay-k-8644 and Diabetes Mellitus
| Article | Year |
|---|---|
Altered inotropic reactivity in diabetic rabbit right ventricular myocardium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2004 |