bay-k-8644 has been researched along with Coronary Disease in 9 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonazepam and PK 11209 were both inactive in this regard." | 1.28 | Interactions between peripheral-type benzodiazepine receptor ligands and an activator of voltage-operated calcium channels. ( Abraham, S; Bolger, GT; Oz, N; Weissman, BA, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (55.56) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sargent, CA | 1 |
| Vesterqvist, O | 1 |
| McCullough, JR | 1 |
| Ogletree, ML | 1 |
| Grover, GJ | 2 |
| Bolger, GT | 1 |
| Abraham, S | 1 |
| Oz, N | 1 |
| Weissman, BA | 1 |
| Billman, GE | 1 |
| McIlroy, B | 1 |
| Johnson, JD | 1 |
| Maruyama, T | 1 |
| Cascio, WE | 1 |
| Knisley, SB | 1 |
| Buchanan, J | 1 |
| Gettes, LS | 1 |
| Nayler, WG | 1 |
| Dillon, JS | 1 |
| Elz, JS | 1 |
| McKelvie, M | 1 |
| Thuillez, C | 1 |
| Berdeaux, A | 1 |
| Duhaze, P | 1 |
| Bonhenry, C | 1 |
| Giudicelli, JF | 1 |
| Kabell, G | 1 |
| van Amsterdam, FT | 1 |
| Punt, NC | 1 |
| Haas, M | 1 |
| van Amsterdam-Magnoni, MS | 1 |
| Zaagsma, J | 1 |
| Parham, CS | 1 |
| Sleph, PG | 1 |
| Moreland, S | 1 |
9 other studies available for bay-k-8644 and Coronary Disease
| Article | Year |
|---|---|
Effect of the phospholipase A2 inhibitors quinacrine and 7,7-dimethyleicosadienoic acid in isolated globally ischemic rat hearts.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Interactions between peripheral-type benzodiazepine receptor ligands and an activator of voltage-operated calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Elevated myocardial calcium and its role in sudden cardiac death.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Effects of ryanodine and BAY K 8644 on membrane properties and conduction during simulated ischemia.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
An effect of ischemia on myocardial dihydropyridine binding sites.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1985 |
Comparison of the effects of Bay K 8644 and aortic constriction on regional myocardial blood flow and function in canine nonischemic and ischemic myocardium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1988 |
Modulation of conduction slowing in ischemic rabbit myocardium by calcium-channel activation and blockade.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1988 |
Stereoisomers of BAY K 8644 show opposite activities in the normal and ischaemic rat heart. A comparison with nifedipine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1989 |
Anti-ischemic and vasorelaxant effects of the new benzazepine calcium channel blocker SQ 31,765.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1989 |