bay-k-8644 has been researched along with Colonic Neoplasms in 1 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with verapamil completely abolished both calcium channel agonist-induced influx of calcium and apoptosis in these cells." | 1.35 | Verapamil inhibits L-type calcium channel mediated apoptosis in human colon cancer cells. ( Jeppsson, B; Liu, Q; Melander, A; Thorlacius, H; Wang, Y; Zawadzki, A, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zawadzki, A | 1 |
| Liu, Q | 1 |
| Wang, Y | 1 |
| Melander, A | 1 |
| Jeppsson, B | 1 |
| Thorlacius, H | 1 |
1 other study available for bay-k-8644 and Colonic Neoplasms
| Article | Year |
|---|---|
Verapamil inhibits L-type calcium channel mediated apoptosis in human colon cancer cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2008 |