bay-k-8644 has been researched along with Cirrhoses, Experimental Liver in 3 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pressor dose-response curves to endothelin 1 (0." | 1.29 | Vascular hyporesponsiveness to endothelin 1 in rats with cirrhosis. ( Cailmail, S; Gaudin, C; Hartleb, M; Lebrec, D; Moreau, R, 1994) |
| "Thus, pressor dose-response curves to vasoconstrictors [phenylephrine (an alpha 1-agonist, 0." | 1.29 | Lack of vascular hyporesponsiveness to the L-type calcium channel activator, Bay K 8644, in rats with cirrhosis. ( Gaudin, C; Hartleb, M; Lebrec, D; Moreau, R, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hartleb, M | 2 |
| Moreau, R | 3 |
| Cailmail, S | 2 |
| Gaudin, C | 2 |
| Lebrec, D | 3 |
| Oberti, F | 1 |
| Lahaye, P | 1 |
| Gadano, A | 1 |
| Sogni, P | 1 |
| Cales, P | 1 |
3 other studies available for bay-k-8644 and Cirrhoses, Experimental Liver
| Article | Year |
|---|---|
Vascular hyporesponsiveness to endothelin 1 in rats with cirrhosis.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Lack of vascular hyporesponsiveness to the L-type calcium channel activator, Bay K 8644, in rats with cirrhosis.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
In vitro and in vivo vascular responses to the L-type calcium channel activator, Bay K 8644, in rats with cirrhosis.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1998 |