bay-k-8644 has been researched along with Cardiac Failure in 9 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moltzau, LR | 1 |
| Aronsen, JM | 1 |
| Meier, S | 1 |
| Nguyen, CH | 1 |
| Hougen, K | 1 |
| Ørstavik, Ø | 1 |
| Sjaastad, I | 1 |
| Christensen, G | 1 |
| Skomedal, T | 1 |
| Osnes, JB | 1 |
| Levy, FO | 1 |
| Qvigstad, E | 1 |
| Kashihara, T | 1 |
| Nakada, T | 1 |
| Shimojo, H | 1 |
| Horiuchi-Hirose, M | 1 |
| Gomi, S | 1 |
| Shibazaki, T | 1 |
| Sheng, X | 1 |
| Hirose, M | 1 |
| Hongo, M | 1 |
| Yamada, M | 1 |
| Kamp, TJ | 1 |
| He, JQ | 1 |
| Chen, X | 2 |
| Piacentino, V | 3 |
| Furukawa, S | 1 |
| Goldman, B | 1 |
| Margulies, KB | 2 |
| Houser, SR | 3 |
| Zhang, X | 1 |
| Harris, DM | 1 |
| Berretta, RM | 1 |
| Ruf, T | 1 |
| Hebisch, S | 1 |
| Gross, R | 1 |
| Alpert, N | 1 |
| Just, H | 1 |
| Holubarsch, C | 1 |
| Kim, CS | 1 |
| Davidoff, AJ | 1 |
| Maki, TM | 1 |
| Doye, AA | 1 |
| Gwathmey, JK | 1 |
| Gaughan, JP | 1 |
| Colucci, WS | 1 |
| Wright, RF | 1 |
| Braunwald, E | 1 |
1 review available for bay-k-8644 and Cardiac Failure
| Article | Year |
|---|---|
New positive inotropic agents in the treatment of congestive heart failure. Mechanisms of action and recent clinical developments. 2.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1986 |
8 other studies available for bay-k-8644 and Cardiac Failure
| Article | Year |
|---|---|
SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2013 |
Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca²⁺ channel activity through phosphatases in heart failure.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2012 |
L-type Ca2+ channels gaining respect in heart failure.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |
L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |
Reduced effects of BAY K 8644 on L-type Ca2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2008 |
Modulation of myocardial economy and efficiency in mammalian failing and non-failing myocardium by calcium channel activation and beta-adrenergic stimulation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1996 |
Intracellular calcium and the relationship to contractility in an avian model of heart failure.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2000 |
L-type Ca(2+) currents overlapping threshold Na(+) currents: could they be responsible for the "slip-mode" phenomenon in cardiac myocytes?
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |