Page last updated: 2024-10-23

bay-k-8644 and Cancer of Prostate

bay-k-8644 has been researched along with Cancer of Prostate in 2 studies

3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.

Research Excerpts

ExcerptRelevanceReference
"Bone metastatic prostate cancer is one of the most common malignancies in developed countries and the second leading cause of cancer-related death in men."1.62The botanical component p-hydroxycinnamic acid suppresses the growth and bone metastatic activity of human prostate cancer PC-3 cells in vitro. ( Murata, T; Ramos, JW; Yamaguchi, M, 2021)
"Collectively, in PC3 human prostate cancer cells, BayK 8644 induced a [Ca²⁺]i rise by evoking phospholipase C-independent Ca²⁺ release from the endoplasmic reticulum and Ca²⁺ entry via protein kinase C-sensitive store-operated Ca²⁺ channels (and/or T-type Ca²⁺ channels)."1.39Effect of BayK 8644 on [Ca²⁺]i and viability in PC3 human prostate cancer cells. ( Chou, CT; Huang, JK; Jan, CR; Lai, ZR; Liang, WZ; Liu, SI, 2013)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's1 (50.00)2.80

Authors

AuthorsStudies
Yamaguchi, M1
Murata, T1
Ramos, JW1
Lai, ZR1
Chou, CT1
Liu, SI1
Liang, WZ1
Huang, JK1
Jan, CR1

Other Studies

2 other studies available for bay-k-8644 and Cancer of Prostate

ArticleYear
The botanical component p-hydroxycinnamic acid suppresses the growth and bone metastatic activity of human prostate cancer PC-3 cells in vitro.
    Journal of cancer research and clinical oncology, 2021, Volume: 147, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2021
Effect of BayK 8644 on [Ca²⁺]i and viability in PC3 human prostate cancer cells.
    The Chinese journal of physiology, 2013, Dec-31, Volume: 56, Issue:6

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2013