bay-k-8644 has been researched along with Cancer of Prostate in 2 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
Excerpt | Relevance | Reference |
---|---|---|
"Bone metastatic prostate cancer is one of the most common malignancies in developed countries and the second leading cause of cancer-related death in men." | 1.62 | The botanical component p-hydroxycinnamic acid suppresses the growth and bone metastatic activity of human prostate cancer PC-3 cells in vitro. ( Murata, T; Ramos, JW; Yamaguchi, M, 2021) |
"Collectively, in PC3 human prostate cancer cells, BayK 8644 induced a [Ca²⁺]i rise by evoking phospholipase C-independent Ca²⁺ release from the endoplasmic reticulum and Ca²⁺ entry via protein kinase C-sensitive store-operated Ca²⁺ channels (and/or T-type Ca²⁺ channels)." | 1.39 | Effect of BayK 8644 on [Ca²⁺]i and viability in PC3 human prostate cancer cells. ( Chou, CT; Huang, JK; Jan, CR; Lai, ZR; Liang, WZ; Liu, SI, 2013) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (50.00) | 24.3611 |
2020's | 1 (50.00) | 2.80 |
Authors | Studies |
---|---|
Yamaguchi, M | 1 |
Murata, T | 1 |
Ramos, JW | 1 |
Lai, ZR | 1 |
Chou, CT | 1 |
Liu, SI | 1 |
Liang, WZ | 1 |
Huang, JK | 1 |
Jan, CR | 1 |
2 other studies available for bay-k-8644 and Cancer of Prostate
Article | Year |
---|---|
The botanical component p-hydroxycinnamic acid suppresses the growth and bone metastatic activity of human prostate cancer PC-3 cells in vitro.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2021 |
Effect of BayK 8644 on [Ca²⁺]i and viability in PC3 human prostate cancer cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2013 |