bay-k-8644 has been researched along with Blood Pressure, Low in 4 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nifedipine and CGP 28392 treatment of nonpregnant and pregnant animals, respectively, did not modify the response of aortic rings to KCl." | 1.31 | Calcium channels contribute to the decrease in blood pressure of pregnant rats. ( Brochu, M; Cadorette, C; Poterek, M; Simaan, M; St-Louis, J, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, LX | 1 |
| Zhang, SQ | 1 |
| Cao, YX | 1 |
| Watanabe, TX | 1 |
| Itahara, Y | 1 |
| Kuroda, H | 1 |
| Chen, YN | 1 |
| Kimura, T | 1 |
| Sakakibara, S | 1 |
| Tuncok, Y | 1 |
| Apaydin, S | 1 |
| Gelal, A | 1 |
| Ates, M | 1 |
| Guven, H | 1 |
| Simaan, M | 1 |
| Cadorette, C | 1 |
| Poterek, M | 1 |
| St-Louis, J | 1 |
| Brochu, M | 1 |
4 other studies available for bay-k-8644 and Blood Pressure, Low
| Article | Year |
|---|---|
Vasodilation and hypotension of CZ454, an analogue of lacidipine through inhibiting extracellular calcium influx.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Pyridinecarboxylic acid, 1,4-d | 2012 |
Smooth muscle relaxing and hypotensive activities of synthetic calciseptine and the homologous snake venom peptide FS2.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
The effects of 4-aminopyridine and Bay K 8644 on verapamil-induced cardiovascular toxicity in anesthetized rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1998 |
Calcium channels contribute to the decrease in blood pressure of pregnant rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |