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bay-k-8644 and Autoimmune Diabetes

bay-k-8644 has been researched along with Autoimmune Diabetes in 3 studies

3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.

Research Excerpts

ExcerptRelevanceReference
"Serum from patients with IDDM increased L-type calcium channel activity of insulin-producing cells and of GH3 cells derived from a pituitary tumor."1.29Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes. ( Ammälä, C; Bokvist, K; Dypbukt, J; Hallberg, A; Juntti-Berggren, L; Larsson, O; Nicotera, P; Orrenius, S; Rorsman, P; Wåhlander, K, 1993)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jackson, MW2
Gordon, TP2
Wan, EC1
Juntti-Berggren, L1
Larsson, O1
Rorsman, P1
Ammälä, C1
Bokvist, K1
Wåhlander, K1
Nicotera, P1
Dypbukt, J1
Orrenius, S1
Hallberg, A1

Other Studies

3 other studies available for bay-k-8644 and Autoimmune Diabetes

ArticleYear
A novel impedance-based cellular assay for the detection of anti-calcium channel autoantibodies in type 1 diabetes.
    Journal of immunological methods, 2010, Sep-30, Volume: 361, Issue:1-2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2010
Autoantibody-mediated bladder dysfunction in type 1 diabetes.
    Scandinavian journal of immunology, 2007, Volume: 65, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2007
Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes.
    Science (New York, N.Y.), 1993, Jul-02, Volume: 261, Issue:5117

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1993