bay-k-8644 has been researched along with Atrial Fibrillation in 5 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
Atrial Fibrillation: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Atrial contractile dysfunction after short-term atrial fibrillation is reduced by the calcium antagonist verapamil, which suggests that transsarcolemmal calcium influx contributed to this dysfunction." | 7.69 | Atrial contractile dysfunction after short-term atrial fibrillation is reduced by verapamil but increased by BAY K8644. ( Aksnes, G; Christensen, G; Leistad, E; Verburg, E, 1996) |
| "Atrial contractile dysfunction after short-term atrial fibrillation is reduced by the calcium antagonist verapamil, which suggests that transsarcolemmal calcium influx contributed to this dysfunction." | 3.69 | Atrial contractile dysfunction after short-term atrial fibrillation is reduced by verapamil but increased by BAY K8644. ( Aksnes, G; Christensen, G; Leistad, E; Verburg, E, 1996) |
| "In patients with persistent atrial fibrillation (AF), the atrial myocardium is characterized by a reduced contractile force, by a shortened duration of the action potential and a recently demonstrated reduction of the L-type Ca2+ currents." | 1.31 | L-type calcium currents in atrial myocytes from patients with persistent and non-persistent atrial fibrillation. ( Jüngling, E; Lückhoff, A; Picht, E; Schöndube, F; Skasa, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chahine, M | 1 |
| Qu, Y | 1 |
| Mancarella, S | 1 |
| Boutjdir, M | 1 |
| Leistad, E | 1 |
| Aksnes, G | 1 |
| Verburg, E | 1 |
| Christensen, G | 1 |
| Schotten, U | 1 |
| Ausma, J | 1 |
| Stellbrink, C | 1 |
| Sabatschus, I | 1 |
| Vogel, M | 1 |
| Frechen, D | 1 |
| Schoendube, F | 1 |
| Hanrath, P | 1 |
| Allessie, MA | 1 |
| Skasa, M | 1 |
| Jüngling, E | 1 |
| Picht, E | 1 |
| Schöndube, F | 1 |
| Lückhoff, A | 1 |
| Anyukhovsky, EP | 1 |
| Sosunov, EA | 1 |
| Plotnikov, A | 1 |
| Gainullin, RZ | 1 |
| Jhang, JS | 1 |
| Marboe, CC | 1 |
| Rosen, MR | 1 |
5 other studies available for bay-k-8644 and Atrial Fibrillation
| Article | Year |
|---|---|
Protein kinase C activation inhibits alpha1D L-type Ca channel: a single-channel analysis.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2008 |
Atrial contractile dysfunction after short-term atrial fibrillation is reduced by verapamil but increased by BAY K8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1996 |
Cellular mechanisms of depressed atrial contractility in patients with chronic atrial fibrillation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2001 |
L-type calcium currents in atrial myocytes from patients with persistent and non-persistent atrial fibrillation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2001 |
Cellular electrophysiologic properties of old canine atria provide a substrate for arrhythmogenesis.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |