bay-k-8644 has been researched along with Arrhythmias, Cardiac in 14 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cardiac arrhythmias associated with intracellular calcium inhomeostasis are refractory to antiarrhythmic therapy." | 1.46 | Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions. ( Chu, YP; Ding, YS; Huang, SH; Huo, Y; Ren, L; Wang, P; Wei, XH; Wu, L; Yang, QM; Yang, W; Yu, SD, 2017) |
| "Effects of verapamil on arrhythmias induced by Bay K8644 (a calcium channel agonist) were also determined." | 1.39 | Anti-arrhythmic effect of verapamil is accompanied by preservation of cx43 protein in rat heart. ( Chen, M; Pei, JM; Wang, QL; Wu, Q; Zhang, SM; Zhou, P, 2013) |
| "The results showed that the arrhythmia score was significantly higher in the SGIR group as compared with the NC and NCEA groups." | 1.35 | Antiarrhythmic effect of acupuncture pretreatment in rats subjected to simulative global ischemia and reperfusion--involvement of adenylate cyclase, protein kinase A, and L-type Ca2+ channel. ( Cui, H; Fu, W; Gao, J; Lu, B; Wang, H; Wang, Y; Yu, X; Yu, Y; Zhang, L, 2008) |
| "Low flow induced arrhythmias, which were potentiated by NE, but not by 10(-6)mol/l U50,488H." | 1.30 | Anti-arrhythmic effect of kappa-opioid receptor stimulation in the perfused rat heart: involvement of a cAMP-dependent pathway. ( Pei, JM; Wang, HX; Wong, TM; Yu, XC, 1999) |
| "Larger doses of BAY K 8644 produced arrhythmias only in 12 months old rats, which was not totally abolished by nitroglycerine pretreatment." | 1.28 | Enhancement in myocardial inotropic response to BAY K 8644 with advancing age. ( Khatter, JC; Navaratnam, S, 1992) |
| "The similarity of mechanisms of arrhythmias induced by ischemia using the presented model is discussed." | 1.28 | [Changes in balance of ionic currents of cardiac cells as one of the mechanisms of arrhythmia]. ( Burnashev, NA; Dzheniuari, K; Fledervish, IA; Iuriavichius, I; Ridl, Zh; Rozenshtraukh, LV; Siuĭ, Ch; Undrovinas, AI; Zablotskaĭte, D, 1990) |
| "Since EADs underlie some types of arrhythmias, arrhythmias caused by ET-1 are at least partly attributable to the direct actions of the agent on myocardial cells." | 1.28 | Electrophysiological effects of endothelin-1 on canine myocardial cells. ( Koike, H; Miyake, S; Yorikane, R, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wei, XH | 1 |
| Yu, SD | 1 |
| Ren, L | 1 |
| Huang, SH | 1 |
| Yang, QM | 1 |
| Wang, P | 1 |
| Chu, YP | 1 |
| Yang, W | 1 |
| Ding, YS | 1 |
| Huo, Y | 1 |
| Wu, L | 1 |
| Zhou, P | 1 |
| Zhang, SM | 1 |
| Wang, QL | 1 |
| Wu, Q | 1 |
| Chen, M | 1 |
| Pei, JM | 2 |
| Horváth, B | 1 |
| Hegyi, B | 1 |
| Kistamás, K | 1 |
| Váczi, K | 1 |
| Bányász, T | 1 |
| Magyar, J | 1 |
| Szentandrássy, N | 1 |
| Nánási, PP | 1 |
| Gao, J | 1 |
| Zhang, L | 1 |
| Wang, Y | 1 |
| Lu, B | 1 |
| Cui, H | 1 |
| Fu, W | 1 |
| Wang, H | 1 |
| Yu, Y | 1 |
| Yu, X | 1 |
| Jonsson, MK | 1 |
| Vos, MA | 1 |
| Mirams, GR | 1 |
| Duker, G | 1 |
| Sartipy, P | 1 |
| de Boer, TP | 1 |
| van Veen, TA | 1 |
| de Diego, C | 1 |
| Pai, RK | 1 |
| Dave, AS | 1 |
| Lynch, A | 1 |
| Thu, M | 1 |
| Chen, F | 1 |
| Xie, LH | 1 |
| Weiss, JN | 1 |
| Valderrábano, M | 1 |
| Song, Y | 1 |
| Belardinelli, L | 1 |
| Zeng, J | 1 |
| Rudy, Y | 1 |
| Yu, XC | 1 |
| Wang, HX | 1 |
| Wong, TM | 1 |
| Tweedie, D | 1 |
| Harding, SE | 1 |
| MacLeod, KT | 1 |
| Khatter, JC | 1 |
| Navaratnam, S | 1 |
| Undrovinas, AI | 1 |
| Burnashev, NA | 1 |
| Fledervish, IA | 1 |
| Dzheniuari, K | 1 |
| Iuriavichius, I | 1 |
| Ridl, Zh | 1 |
| Zablotskaĭte, D | 1 |
| Siuĭ, Ch | 1 |
| Rozenshtraukh, LV | 1 |
| Yorikane, R | 1 |
| Koike, H | 1 |
| Miyake, S | 1 |
| January, CT | 1 |
| Riddle, JM | 1 |
14 other studies available for bay-k-8644 and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2017 |
Anti-arrhythmic effect of verapamil is accompanied by preservation of cx43 protein in rat heart.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2013 |
Cytosolic calcium changes affect the incidence of early afterdepolarizations in canine ventricular myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2015 |
Antiarrhythmic effect of acupuncture pretreatment in rats subjected to simulative global ischemia and reperfusion--involvement of adenylate cyclase, protein kinase A, and L-type Ca2+ channel.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2008 |
Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2012 |
Spatially discordant alternans in cardiomyocyte monolayers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2008 |
ATP promotes development of afterdepolarizations and triggered activity in cardiac myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Anti-arrhythmic effect of kappa-opioid receptor stimulation in the perfused rat heart: involvement of a cAMP-dependent pathway.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Sarcoplasmic reticulum Ca content, sarcolemmal Ca influx and the genesis of arrhythmias in isolated guinea-pig cardiomyocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2000 |
Enhancement in myocardial inotropic response to BAY K 8644 with advancing age.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
[Changes in balance of ionic currents of cardiac cells as one of the mechanisms of arrhythmia].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Electrophysiological effects of endothelin-1 on canine myocardial cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ current.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1989 |