bay-k-8644 has been researched along with Arrhythmia in 14 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cardiac arrhythmias associated with intracellular calcium inhomeostasis are refractory to antiarrhythmic therapy." | 1.46 | Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions. ( Chu, YP; Ding, YS; Huang, SH; Huo, Y; Ren, L; Wang, P; Wei, XH; Wu, L; Yang, QM; Yang, W; Yu, SD, 2017) |
| "Effects of verapamil on arrhythmias induced by Bay K8644 (a calcium channel agonist) were also determined." | 1.39 | Anti-arrhythmic effect of verapamil is accompanied by preservation of cx43 protein in rat heart. ( Chen, M; Pei, JM; Wang, QL; Wu, Q; Zhang, SM; Zhou, P, 2013) |
| "The results showed that the arrhythmia score was significantly higher in the SGIR group as compared with the NC and NCEA groups." | 1.35 | Antiarrhythmic effect of acupuncture pretreatment in rats subjected to simulative global ischemia and reperfusion--involvement of adenylate cyclase, protein kinase A, and L-type Ca2+ channel. ( Cui, H; Fu, W; Gao, J; Lu, B; Wang, H; Wang, Y; Yu, X; Yu, Y; Zhang, L, 2008) |
| "Low flow induced arrhythmias, which were potentiated by NE, but not by 10(-6)mol/l U50,488H." | 1.30 | Anti-arrhythmic effect of kappa-opioid receptor stimulation in the perfused rat heart: involvement of a cAMP-dependent pathway. ( Pei, JM; Wang, HX; Wong, TM; Yu, XC, 1999) |
| "Larger doses of BAY K 8644 produced arrhythmias only in 12 months old rats, which was not totally abolished by nitroglycerine pretreatment." | 1.28 | Enhancement in myocardial inotropic response to BAY K 8644 with advancing age. ( Khatter, JC; Navaratnam, S, 1992) |
| "The similarity of mechanisms of arrhythmias induced by ischemia using the presented model is discussed." | 1.28 | [Changes in balance of ionic currents of cardiac cells as one of the mechanisms of arrhythmia]. ( Burnashev, NA; Dzheniuari, K; Fledervish, IA; Iuriavichius, I; Ridl, Zh; Rozenshtraukh, LV; Siuĭ, Ch; Undrovinas, AI; Zablotskaĭte, D, 1990) |
| "Since EADs underlie some types of arrhythmias, arrhythmias caused by ET-1 are at least partly attributable to the direct actions of the agent on myocardial cells." | 1.28 | Electrophysiological effects of endothelin-1 on canine myocardial cells. ( Koike, H; Miyake, S; Yorikane, R, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wei, XH | 1 |
| Yu, SD | 1 |
| Ren, L | 1 |
| Huang, SH | 1 |
| Yang, QM | 1 |
| Wang, P | 1 |
| Chu, YP | 1 |
| Yang, W | 1 |
| Ding, YS | 1 |
| Huo, Y | 1 |
| Wu, L | 1 |
| Zhou, P | 1 |
| Zhang, SM | 1 |
| Wang, QL | 1 |
| Wu, Q | 1 |
| Chen, M | 1 |
| Pei, JM | 2 |
| Horváth, B | 1 |
| Hegyi, B | 1 |
| Kistamás, K | 1 |
| Váczi, K | 1 |
| Bányász, T | 1 |
| Magyar, J | 1 |
| Szentandrássy, N | 1 |
| Nánási, PP | 1 |
| Gao, J | 1 |
| Zhang, L | 1 |
| Wang, Y | 1 |
| Lu, B | 1 |
| Cui, H | 1 |
| Fu, W | 1 |
| Wang, H | 1 |
| Yu, Y | 1 |
| Yu, X | 1 |
| Jonsson, MK | 1 |
| Vos, MA | 1 |
| Mirams, GR | 1 |
| Duker, G | 1 |
| Sartipy, P | 1 |
| de Boer, TP | 1 |
| van Veen, TA | 1 |
| de Diego, C | 1 |
| Pai, RK | 1 |
| Dave, AS | 1 |
| Lynch, A | 1 |
| Thu, M | 1 |
| Chen, F | 1 |
| Xie, LH | 1 |
| Weiss, JN | 1 |
| Valderrábano, M | 1 |
| Song, Y | 1 |
| Belardinelli, L | 1 |
| Zeng, J | 1 |
| Rudy, Y | 1 |
| Yu, XC | 1 |
| Wang, HX | 1 |
| Wong, TM | 1 |
| Tweedie, D | 1 |
| Harding, SE | 1 |
| MacLeod, KT | 1 |
| Khatter, JC | 1 |
| Navaratnam, S | 1 |
| Undrovinas, AI | 1 |
| Burnashev, NA | 1 |
| Fledervish, IA | 1 |
| Dzheniuari, K | 1 |
| Iuriavichius, I | 1 |
| Ridl, Zh | 1 |
| Zablotskaĭte, D | 1 |
| Siuĭ, Ch | 1 |
| Rozenshtraukh, LV | 1 |
| Yorikane, R | 1 |
| Koike, H | 1 |
| Miyake, S | 1 |
| January, CT | 1 |
| Riddle, JM | 1 |
14 other studies available for bay-k-8644 and Arrhythmia
| Article | Year |
|---|---|
Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2017 |
Anti-arrhythmic effect of verapamil is accompanied by preservation of cx43 protein in rat heart.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2013 |
Cytosolic calcium changes affect the incidence of early afterdepolarizations in canine ventricular myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2015 |
Antiarrhythmic effect of acupuncture pretreatment in rats subjected to simulative global ischemia and reperfusion--involvement of adenylate cyclase, protein kinase A, and L-type Ca2+ channel.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2008 |
Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2012 |
Spatially discordant alternans in cardiomyocyte monolayers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2008 |
ATP promotes development of afterdepolarizations and triggered activity in cardiac myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Anti-arrhythmic effect of kappa-opioid receptor stimulation in the perfused rat heart: involvement of a cAMP-dependent pathway.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Sarcoplasmic reticulum Ca content, sarcolemmal Ca influx and the genesis of arrhythmias in isolated guinea-pig cardiomyocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2000 |
Enhancement in myocardial inotropic response to BAY K 8644 with advancing age.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
[Changes in balance of ionic currents of cardiac cells as one of the mechanisms of arrhythmia].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Electrophysiological effects of endothelin-1 on canine myocardial cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ current.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1989 |