bay-k-8644 has been researched along with Anesthesia in 13 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Hemodynamics and left ventricular pressure-segment length diagrams were recorded after a 10-min equilibration at each dose in the conscious state or during isoflurane or halothane anesthesia (0." | 3.69 | Left ventricular mechanical consequences of dihydropyridine calcium channel modulation in conscious and anesthetized chronically instrumented dogs. ( Hettrick, DA; Pagel, PS; Warltier, DC, 1994) |
| "Clonazepam did not produce anaesthesia, at doses up to 1 g kg-1 or when given with nitrendipine." | 1.28 | Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644. ( Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Taberner, PV, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 7 (53.85) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Badejo, AM | 1 |
| Dhaliwal, JS | 1 |
| Casey, DB | 1 |
| Gallen, TB | 1 |
| Greco, AJ | 1 |
| Kadowitz, PJ | 1 |
| Ma, HJ | 1 |
| Liu, YX | 2 |
| Wang, FW | 3 |
| Wang, LX | 1 |
| He, RR | 3 |
| Wu, YM | 3 |
| Xue, HM | 1 |
| Xiao, L | 2 |
| Wang, R | 2 |
| Pagel, PS | 1 |
| Hettrick, DA | 1 |
| Warltier, DC | 1 |
| Takeuchi, A | 1 |
| Kimura, T | 1 |
| Satoh, S | 2 |
| Venuto, R | 1 |
| Brown, G | 1 |
| Schoenl, M | 1 |
| Losonczy, G | 1 |
| Suzuki, Y | 1 |
| Matsumura, Y | 1 |
| Umekawa, T | 1 |
| Hayashi, K | 1 |
| Takaoka, M | 1 |
| Morimoto, S | 1 |
| Chillon, JM | 1 |
| Gellotte, M | 1 |
| Ferrandon, P | 1 |
| Lartaud, I | 1 |
| Martin, D | 1 |
| Armstrong, JM | 1 |
| Atkinson, J | 1 |
| Hicks, PE | 1 |
| Takahara, A | 1 |
| Suzuki-Kusaba, M | 1 |
| Hisa, H | 1 |
| Adachi, H | 1 |
| Shoji, T | 1 |
| Goto, K | 1 |
| Dolin, SJ | 1 |
| Patch, TL | 1 |
| Rabbani, M | 1 |
| Taberner, PV | 1 |
| Little, HJ | 1 |
| Tolins, M | 1 |
| Weir, EK | 1 |
| Chesler, E | 1 |
| Nelson, DP | 1 |
| From, AH | 1 |
13 other studies available for bay-k-8644 and Anesthesia
| Article | Year |
|---|---|
Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13 | 2008 |
Genistein inhibits carotid sinus baroreceptor activity in anesthetized male rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2005 |
Effect of resveratrol on baroreceptor activity of carotid sinus in anesthetized male rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2007 |
Hydrogen sulfide facilitates carotid sinus baroreceptor activity in anesthetized male rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2007 |
Left ventricular mechanical consequences of dihydropyridine calcium channel modulation in conscious and anesthetized chronically instrumented dogs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Effects of nifedipine and Bay-K-8644 on the release of catecholamines from the dog adrenal gland in response to splanchnic nerve stimulation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Enhanced vascular effects of the Ca(2+) channel agonist Bay K 8644 in pregnant rabbits.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |
Effects of endothelin-1 on antidiuresis and norepinephrine overflow induced by stimulation of renal nerves in anesthetized dogs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Haemodynamic effects of the calcium facilitator Bay K-8644 in rats following vascular calcium overload.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Effects of a novel Ca2+ entry blocker, CD-349, and TMB-8 on renal vasoconstriction induced by angiotensin II and vasopressin in dogs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Comparison of the effects of endothelin and Bay k 8644 on cardiohemodynamics in anesthetized pigs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Pulmonary vascular tone is increased by a voltage-dependent calcium channel potentiator.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1986 |