bay-k-8644 has been researched along with Alloxan Diabetes in 27 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study was undertaken to compare the cardiomyopathies induced by experimental diabetes mellitus and chronic isoproterenol (ISO) pretreatment on inotropic reactivity of right ventricular strips from rats." | 7.68 | Pharmacological study of isoproterenol and diabetic cardiomyopathies in rat right ventricular strips. ( Gunasekaran, S; Tenner, TE; Young, JA, 1993) |
| "The present study was undertaken to compare the cardiomyopathies induced by experimental diabetes mellitus and chronic isoproterenol (ISO) pretreatment on inotropic reactivity of right ventricular strips from rats." | 3.68 | Pharmacological study of isoproterenol and diabetic cardiomyopathies in rat right ventricular strips. ( Gunasekaran, S; Tenner, TE; Young, JA, 1993) |
| " The dose-response curves for high K(+), ACh, and ET-1 were shifted to the left, so that at some lower doses of these agents the increased perfusion pressure was greater in coronary arteries obtained from diabetic rats than in those from control rats." | 1.35 | Effect of long-term streptozotocin-induced diabetes on coronary vasoconstriction in isolated perfused rat heart. ( Kamata, K; Kobayashi, T; Matsumoto, T; Ozawa, Y, 2008) |
| " The dose-response curve of insulin secretion showed a markedly reduced maximum response, but almost normal glucose sensitivity in NSY islets." | 1.31 | Insulin secretion to glucose as well as nonglucose stimuli is impaired in spontaneously diabetic Nagoya-Shibata-Yasuda mice. ( Babaya, N; Hamada, Y; Ikegami, H; Kawaguchi, Y; Nojima, K; Ogihara, T; Shibata, M; Ueda, H; Yamada, K; Yamato, E, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.11) | 18.7374 |
| 1990's | 17 (62.96) | 18.2507 |
| 2000's | 7 (25.93) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kamata, K | 4 |
| Ozawa, Y | 2 |
| Kobayashi, T | 2 |
| Matsumoto, T | 2 |
| Nakahara, T | 1 |
| Mitani, A | 1 |
| Kubota, Y | 1 |
| Maruko, T | 1 |
| Sakamoto, K | 1 |
| Tanaka, Y | 1 |
| Koike, K | 1 |
| Shigenobu, K | 1 |
| Ishii, K | 1 |
| Forrest, A | 1 |
| Molleman, A | 1 |
| Parsons, M | 1 |
| Roth, DM | 1 |
| Foster, KA | 1 |
| Lefer, AM | 1 |
| Sakai, Y | 2 |
| Inazu, M | 2 |
| Shamoto, A | 1 |
| Zhu, B | 1 |
| Homma, I | 2 |
| Abebe, W | 1 |
| Harris, KH | 1 |
| MacLeod, KM | 1 |
| Tesfamariam, B | 1 |
| Cohen, RA | 1 |
| Gunasekaran, S | 1 |
| Young, JA | 1 |
| Tenner, TE | 1 |
| Beenen, OH | 1 |
| Pfaffendorf, M | 1 |
| van Zwieten, PA | 2 |
| Carmines, PK | 1 |
| Ohishi, K | 1 |
| Ikenaga, H | 1 |
| Yoo, HJ | 1 |
| Kozaki, K | 1 |
| Akishita, M | 1 |
| Watanabe, M | 1 |
| Eto, M | 2 |
| Nagano, K | 1 |
| Sudo, N | 1 |
| Hashimoto, M | 1 |
| Kim, S | 1 |
| Yoshizumi, M | 1 |
| Toba, K | 1 |
| Ouchi, Y | 1 |
| Kawasaki, H | 1 |
| Gohshi, A | 1 |
| Honda, K | 1 |
| Tominaga, K | 1 |
| Takano, Y | 1 |
| Motoya, T | 1 |
| Yamada, K | 2 |
| Kamiya, H | 1 |
| Ungvari, Z | 1 |
| Pacher, P | 1 |
| Kecskemeti, V | 1 |
| Papp, G | 1 |
| Szollár, L | 1 |
| Koller, A | 1 |
| Wang, R | 1 |
| Wu, Y | 1 |
| Tang, G | 1 |
| Wu, L | 1 |
| Hanna, ST | 1 |
| Iwashima, Y | 1 |
| Abiko, A | 1 |
| Ushikubi, F | 1 |
| Hata, A | 1 |
| Kaku, K | 1 |
| Sano, H | 1 |
| Hamada, Y | 1 |
| Ikegami, H | 1 |
| Ueda, H | 1 |
| Kawaguchi, Y | 1 |
| Yamato, E | 1 |
| Nojima, K | 1 |
| Babaya, N | 1 |
| Shibata, M | 1 |
| Ogihara, T | 1 |
| Heijnis, JB | 1 |
| Belis, JA | 2 |
| Curley, RM | 2 |
| Murty, VN | 2 |
| Wagner, CH | 2 |
| Winter, SJ | 2 |
| Rohner, TJ | 2 |
| White, RE | 1 |
| Carrier, GO | 1 |
| Abiru, T | 1 |
| Miyata, N | 2 |
| Kasuya, Y | 2 |
| Yu, Z | 1 |
| McNeill, JH | 2 |
| Agrawal, DK | 1 |
27 other studies available for bay-k-8644 and Alloxan Diabetes
| Article | Year |
|---|---|
Effect of long-term streptozotocin-induced diabetes on coronary vasoconstriction in isolated perfused rat heart.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2008 |
Effect of N-epsilon-(carboxymethyl)lysine on coronary vasoconstriction in isolated perfused hearts from control and streptozotocin-induced diabetic rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2009 |
MaxiK channel-triggered negative feedback system is preserved in the urinary bladder smooth muscle from streptozotocin-induced diabetic rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2004 |
The responses to manipulation of extracellular and intracellular calcium are altered in the streptozotocin-diabetic rat colon and ileum.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2005 |
Coronary vascular responsiveness to non-eicosanoid vasoconstrictors in the perfused diabetic rat heart.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1984 |
Contractile hyperreactivity and alteration of PKC activity in gastric fundus smooth muscle of diabetic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5 | 1994 |
Role of extracellular Ca2+ in the selective enhancement of contractile responses of arteries from diabetic rats to noradrenaline.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Enhanced adrenergic neurotransmission in diabetic rabbit carotid artery.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Pharmacological study of isoproterenol and diabetic cardiomyopathies in rat right ventricular strips.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Contractile responses to various inotropic agents in isolated hearts obtained from hypertensive diabetic rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Functional impairment of renal afferent arteriolar voltage-gated calcium channels in rats with diabetes mellitus.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1996 |
Augmented Ca2+ influx is involved in the mechanism of enhanced proliferation of cultured vascular smooth muscle cells from spontaneously diabetic Goto-Kakizaki rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
[Pharmacological studies on alterations in contractile reactivity in aortas isolated from experimental diabetic rats].
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Pyridinecarboxylic acid, 1,4-d | 1997 |
Changes in adrenocorticotropic hormone (ACTH) release from the cultured anterior pituitary cells of streptozotocin-induced diabetic rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1998 |
Increased myogenic tone in skeletal muscle arterioles of diabetic rats. Possible role of increased activity of smooth muscle Ca2+ channels and protein kinase C.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Altered L-type Ca(2+) channel currents in vascular smooth muscle cells from experimental diabetic rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2000 |
Downregulation of the voltage-dependent calcium channel (VDCC) beta-subunit mRNAs in pancreatic islets of type 2 diabetic rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2001 |
Insulin secretion to glucose as well as nonglucose stimuli is impaired in spontaneously diabetic Nagoya-Shibata-Yasuda mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2001 |
Enhanced inotropic responsiveness to alpha 1-adrenoceptor stimulation in isolated working hearts from diabetic rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Calcium channel agonist/antagonist effects on cholinergic stimulation of the diabetic rat bladder.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Vascular contraction induced by activation of membrane calcium ion channels is enhanced in streptozotocin-diabetes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Differences in vascular responses to vasoactive agents of basilar artery and aorta from rabbits with alloxan-induced diabetes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Altered inotropic responses in diabetic cardiomyopathy and hypertensive-diabetic cardiomyopathy.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Neurogenic function of the diabetic rat bladder: alteration by calcium channel effectors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Contractile responses and calcium mobilization in renal arteries of diabetic rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Vascular responses to agonists in rat mesenteric artery from diabetic rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Mechanisms of increased responses of the aorta to alpha-adrenoceptor agonists in streptozotocin-induced diabetic rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1988 |