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bay-k-8644 and Aging

bay-k-8644 has been researched along with Aging in 24 studies

3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" Using this system, we have previously shown that (a) complete removal of the hippocampus blocks acquisition of the conditioned response; (b) a calcium-dependent postsynaptic afterhyperpolarization is reduced in pyramidal cells recorded intracellularly in hippocampal slices taken from conditioned rabbits; and (c) nimodipine, a 1,4-dihydropyridine calcium-channel antagonist, facilitates acquisition of the conditioned response in aging rabbits."7.68Nimodipine enhances spontaneous activity of hippocampal pyramidal neurons in aging rabbits at a dose that facilitates associative learning. ( Deyo, RA; Disterhoft, JF; Thompson, LT, 1990)
"To study the effects of melatonin (Mel) on cortical intrasynaptosomal calcium concentration in old mice and on [Ca2+]i elevation induced by Bay-K-8644, KCl, and sodium l-glutamate in isolated brain cells of neonatal mouse, and to determine the antiaging mechanism of Mel."3.70Inhibitory effects of melatonin on free intracellular calcium in mouse brain cells. ( Zhang, JT; Zhang, QZ, 1999)
" Using this system, we have previously shown that (a) complete removal of the hippocampus blocks acquisition of the conditioned response; (b) a calcium-dependent postsynaptic afterhyperpolarization is reduced in pyramidal cells recorded intracellularly in hippocampal slices taken from conditioned rabbits; and (c) nimodipine, a 1,4-dihydropyridine calcium-channel antagonist, facilitates acquisition of the conditioned response in aging rabbits."3.68Nimodipine enhances spontaneous activity of hippocampal pyramidal neurons in aging rabbits at a dose that facilitates associative learning. ( Deyo, RA; Disterhoft, JF; Thompson, LT, 1990)
"Larger doses of BAY K 8644 produced arrhythmias only in 12 months old rats, which was not totally abolished by nitroglycerine pretreatment."1.28Enhancement in myocardial inotropic response to BAY K 8644 with advancing age. ( Khatter, JC; Navaratnam, S, 1992)
"1."1.28Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in alpha-adrenoceptor responsiveness with age and disease in isolated tissues. ( Christ, GJ; Maayani, S; Melman, A; Valcic, M, 1990)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.33)18.7374
1990's16 (66.67)18.2507
2000's3 (12.50)29.6817
2010's2 (8.33)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Lin, RL1
Frazier, HN1
Anderson, KL1
Case, SL1
Ghoweri, AO1
Thibault, O2
Fukuda, T1
Kuroda, T1
Kono, M1
Miyamoto, T1
Tanaka, M1
Matsui, T1
Lu, CB1
Hamilton, JB1
Powell, AD1
Toescu, EC1
Vreugdenhil, M1
Mulderry, PK1
Van Overloop, B1
Stoclet, JC1
Gairard, A1
Matsubara, H1
Suzuki, J1
Inada, M1
Kanai, AJ1
Mesaros, S1
Finkel, MS1
Oddis, CV1
Birder, LA1
Malinski, T1
Qin, ZL1
Nishimura, H1
Hui, C1
Goto, A1
Yamada, K1
Yagi, N1
Nagoshi, H1
Sasabe, M1
Omata, M1
Sugimoto, T1
Zhang, QZ1
Zhang, JT1
Ren, J1
Jefferson, L1
Sowers, JR1
Brown, RA1
Gomez, JP1
Ghisdal, P1
Morel, N1
Hadley, R1
Landfield, PW1
Anyukhovsky, EP1
Sosunov, EA1
Plotnikov, A1
Gainullin, RZ1
Jhang, JS1
Marboe, CC1
Rosen, MR1
Sakai, M1
Danziger, RS1
Xiao, RP1
Spurgeon, HA1
Lakatta, EG1
Khatter, JC2
Navaratnam, S2
Ruch, S1
Kennedy, RH1
Seifen, E1
Christ, GJ1
Maayani, S1
Valcic, M1
Melman, A1
Thompson, LT1
Deyo, RA1
Disterhoft, JF1
Sorimachi, M1
Yamagami, K1
Morita, Y1
Kuramoto, K1
Wright, G1
Martínez-Serrano, A1
Bogónez, E1
Vitórica, J1
Satrústegui, J1
Wanstall, JC1
O'Donnell, SR1

Other Studies

24 other studies available for bay-k-8644 and Aging

ArticleYear
Sensitivity of the S1 neuronal calcium network to insulin and Bay-K 8644 in vivo: Relationship to gait, motivation, and aging processes.
    Aging cell, 2022, Volume: 21, Issue:7

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2022
Attenuation of L-type Ca²⁺ channel expression and vasomotor response in the aorta with age in both Wistar-Kyoto and spontaneously hypertensive rats.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2014
Effect of ageing on CA3 interneuron sAHP and gamma oscillations is activity-dependent.
    Neurobiology of aging, 2011, Volume: 32, Issue:5

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2011
Synergistic regulation of vasoactive intestinal polypeptide expression by cyclic AMP and calcium in newborn but not adult rat sensory neurons in culture.
    Neuroscience, 1993, Volume: 53, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifl

1993
Age, endothelium and aortic reactivity to calcium in Wistar rat.
    Life sciences, 1993, Volume: 53, Issue:10

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1993
Shaker-related potassium channel, Kv1.4, mRNA regulation in cultured rat heart myocytes and differential expression of Kv1.4 and Kv1.5 genes in myocardial development and hypertrophy.
    The Journal of clinical investigation, 1993, Volume: 92, Issue:4

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1993
Beta-adrenergic regulation of constitutive nitric oxide synthase in cardiac myocytes.
    The American journal of physiology, 1997, Volume: 273, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifl

1997
Ca2+ signaling in fowl aortic smooth muscle increases during maturation but is impaired in neointimal plaques.
    The Journal of experimental biology, 1998, Volume: 201, Issue:Pt 11

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1998
Relations of vascular calcium channels with blood pressure and endothelium in hypertension and with aging.
    Japanese heart journal, 1999, Volume: 40, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1999
Inhibitory effects of melatonin on free intracellular calcium in mouse brain cells.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1999, Volume: 20, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1999
Influence of age on contractile response to insulin-like growth factor 1 in ventricular myocytes from spontaneously hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 1999, Volume: 34, Issue:6

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1999
Changes of the potassium currents in rat aortic smooth muscle cells during postnatal development.
    Pflugers Archiv : European journal of physiology, 2000, Volume: 441, Issue:2-3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2000
Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Dec-15, Volume: 21, Issue:24

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2001
Cellular electrophysiologic properties of old canine atria provide a substrate for arrhythmogenesis.
    Cardiovascular research, 2002, Volume: 54, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

2002
Contractile response of individual cardiac myocytes to norepinephrine declines with senescence.
    The American journal of physiology, 1992, Volume: 262, Issue:1 Pt 2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1992
Enhancement in myocardial inotropic response to BAY K 8644 with advancing age.
    European journal of pharmacology, 1992, Jun-17, Volume: 216, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1992
Aging: inotropic effects of Bay K-8644 and nifedipine on rat cardiac muscle.
    European journal of pharmacology, 1992, Jun-17, Volume: 216, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1992
Increase in number of myocardial [3H]BAY K 8644 binding sites during adult maturation of rat.
    Canadian journal of physiology and pharmacology, 1990, Volume: 68, Issue:7

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1990
Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in alpha-adrenoceptor responsiveness with age and disease in isolated tissues.
    British journal of pharmacology, 1990, Volume: 101, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1990
Nimodipine enhances spontaneous activity of hippocampal pyramidal neurons in aging rabbits at a dose that facilitates associative learning.
    Brain research, 1990, Dec-03, Volume: 535, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1990
GABA inhibits the rise in cytosolic free calcium concentration in depolarized immature cerebellar Purkinje cells.
    Neuroscience letters, 1991, Jan-28, Volume: 122, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1991
Use-dependent decline in rat aorta sensitivity to contraction by potassium.
    Canadian journal of physiology and pharmacology, 1991, Volume: 69, Issue:7

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1991
Reduction of K+-stimulated 45Ca2+ influx in synaptosomes with age involves inactivating and noninactivating calcium channels and is correlated with temporal modifications in protein dephosphorylation.
    Journal of neurochemistry, 1989, Volume: 52, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1989
Age influences responses of rat isolated aorta and pulmonary artery to the calcium channel agonist, Bay K 8664, and to potassium and calcium.
    Journal of cardiovascular pharmacology, 1989, Volume: 13, Issue:5

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1989