bay-k-8644 and Aging
bay-k-8644 has been researched along with Aging in 24 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " Using this system, we have previously shown that (a) complete removal of the hippocampus blocks acquisition of the conditioned response; (b) a calcium-dependent postsynaptic afterhyperpolarization is reduced in pyramidal cells recorded intracellularly in hippocampal slices taken from conditioned rabbits; and (c) nimodipine, a 1,4-dihydropyridine calcium-channel antagonist, facilitates acquisition of the conditioned response in aging rabbits." | 7.68 | Nimodipine enhances spontaneous activity of hippocampal pyramidal neurons in aging rabbits at a dose that facilitates associative learning. ( Deyo, RA; Disterhoft, JF; Thompson, LT, 1990) |
| "To study the effects of melatonin (Mel) on cortical intrasynaptosomal calcium concentration in old mice and on [Ca2+]i elevation induced by Bay-K-8644, KCl, and sodium l-glutamate in isolated brain cells of neonatal mouse, and to determine the antiaging mechanism of Mel." | 3.70 | Inhibitory effects of melatonin on free intracellular calcium in mouse brain cells. ( Zhang, JT; Zhang, QZ, 1999) |
| " Using this system, we have previously shown that (a) complete removal of the hippocampus blocks acquisition of the conditioned response; (b) a calcium-dependent postsynaptic afterhyperpolarization is reduced in pyramidal cells recorded intracellularly in hippocampal slices taken from conditioned rabbits; and (c) nimodipine, a 1,4-dihydropyridine calcium-channel antagonist, facilitates acquisition of the conditioned response in aging rabbits." | 3.68 | Nimodipine enhances spontaneous activity of hippocampal pyramidal neurons in aging rabbits at a dose that facilitates associative learning. ( Deyo, RA; Disterhoft, JF; Thompson, LT, 1990) |
| "Larger doses of BAY K 8644 produced arrhythmias only in 12 months old rats, which was not totally abolished by nitroglycerine pretreatment." | 1.28 | Enhancement in myocardial inotropic response to BAY K 8644 with advancing age. ( Khatter, JC; Navaratnam, S, 1992) |
| "1." | 1.28 | Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in alpha-adrenoceptor responsiveness with age and disease in isolated tissues. ( Christ, GJ; Maayani, S; Melman, A; Valcic, M, 1990) |
Research
Studies (24)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.33) | 18.7374 |
| 1990's | 16 (66.67) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 2 (8.33) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Lin, RL | 1 |
| Frazier, HN | 1 |
| Anderson, KL | 1 |
| Case, SL | 1 |
| Ghoweri, AO | 1 |
| Thibault, O | 2 |
| Fukuda, T | 1 |
| Kuroda, T | 1 |
| Kono, M | 1 |
| Miyamoto, T | 1 |
| Tanaka, M | 1 |
| Matsui, T | 1 |
| Lu, CB | 1 |
| Hamilton, JB | 1 |
| Powell, AD | 1 |
| Toescu, EC | 1 |
| Vreugdenhil, M | 1 |
| Mulderry, PK | 1 |
| Van Overloop, B | 1 |
| Stoclet, JC | 1 |
| Gairard, A | 1 |
| Matsubara, H | 1 |
| Suzuki, J | 1 |
| Inada, M | 1 |
| Kanai, AJ | 1 |
| Mesaros, S | 1 |
| Finkel, MS | 1 |
| Oddis, CV | 1 |
| Birder, LA | 1 |
| Malinski, T | 1 |
| Qin, ZL | 1 |
| Nishimura, H | 1 |
| Hui, C | 1 |
| Goto, A | 1 |
| Yamada, K | 1 |
| Yagi, N | 1 |
| Nagoshi, H | 1 |
| Sasabe, M | 1 |
| Omata, M | 1 |
| Sugimoto, T | 1 |
| Zhang, QZ | 1 |
| Zhang, JT | 1 |
| Ren, J | 1 |
| Jefferson, L | 1 |
| Sowers, JR | 1 |
| Brown, RA | 1 |
| Gomez, JP | 1 |
| Ghisdal, P | 1 |
| Morel, N | 1 |
| Hadley, R | 1 |
| Landfield, PW | 1 |
| Anyukhovsky, EP | 1 |
| Sosunov, EA | 1 |
| Plotnikov, A | 1 |
| Gainullin, RZ | 1 |
| Jhang, JS | 1 |
| Marboe, CC | 1 |
| Rosen, MR | 1 |
| Sakai, M | 1 |
| Danziger, RS | 1 |
| Xiao, RP | 1 |
| Spurgeon, HA | 1 |
| Lakatta, EG | 1 |
| Khatter, JC | 2 |
| Navaratnam, S | 2 |
| Ruch, S | 1 |
| Kennedy, RH | 1 |
| Seifen, E | 1 |
| Christ, GJ | 1 |
| Maayani, S | 1 |
| Valcic, M | 1 |
| Melman, A | 1 |
| Thompson, LT | 1 |
| Deyo, RA | 1 |
| Disterhoft, JF | 1 |
| Sorimachi, M | 1 |
| Yamagami, K | 1 |
| Morita, Y | 1 |
| Kuramoto, K | 1 |
| Wright, G | 1 |
| Martínez-Serrano, A | 1 |
| Bogónez, E | 1 |
| Vitórica, J | 1 |
| Satrústegui, J | 1 |
| Wanstall, JC | 1 |
| O'Donnell, SR | 1 |
Other Studies
24 other studies available for bay-k-8644 and Aging
| Article | Year |
|---|---|
Sensitivity of the S1 neuronal calcium network to insulin and Bay-K 8644 in vivo: Relationship to gait, motivation, and aging processes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2022 |
Attenuation of L-type Ca²⁺ channel expression and vasomotor response in the aorta with age in both Wistar-Kyoto and spontaneously hypertensive rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2014 |
Effect of ageing on CA3 interneuron sAHP and gamma oscillations is activity-dependent.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2011 |
Synergistic regulation of vasoactive intestinal polypeptide expression by cyclic AMP and calcium in newborn but not adult rat sensory neurons in culture.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifl | 1993 |
Age, endothelium and aortic reactivity to calcium in Wistar rat.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Shaker-related potassium channel, Kv1.4, mRNA regulation in cultured rat heart myocytes and differential expression of Kv1.4 and Kv1.5 genes in myocardial development and hypertrophy.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Beta-adrenergic regulation of constitutive nitric oxide synthase in cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifl | 1997 |
Ca2+ signaling in fowl aortic smooth muscle increases during maturation but is impaired in neointimal plaques.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1998 |
Relations of vascular calcium channels with blood pressure and endothelium in hypertension and with aging.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Inhibitory effects of melatonin on free intracellular calcium in mouse brain cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Influence of age on contractile response to insulin-like growth factor 1 in ventricular myocytes from spontaneously hypertensive rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Changes of the potassium currents in rat aortic smooth muscle cells during postnatal development.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2000 |
Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2001 |
Cellular electrophysiologic properties of old canine atria provide a substrate for arrhythmogenesis.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |
Contractile response of individual cardiac myocytes to norepinephrine declines with senescence.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Enhancement in myocardial inotropic response to BAY K 8644 with advancing age.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Aging: inotropic effects of Bay K-8644 and nifedipine on rat cardiac muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Increase in number of myocardial [3H]BAY K 8644 binding sites during adult maturation of rat.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in alpha-adrenoceptor responsiveness with age and disease in isolated tissues.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Nimodipine enhances spontaneous activity of hippocampal pyramidal neurons in aging rabbits at a dose that facilitates associative learning.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
GABA inhibits the rise in cytosolic free calcium concentration in depolarized immature cerebellar Purkinje cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Use-dependent decline in rat aorta sensitivity to contraction by potassium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Reduction of K+-stimulated 45Ca2+ influx in synaptosomes with age involves inactivating and noninactivating calcium channels and is correlated with temporal modifications in protein dephosphorylation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1989 |
Age influences responses of rat isolated aorta and pulmonary artery to the calcium channel agonist, Bay K 8664, and to potassium and calcium.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1989 |