bay-k-8644 has been researched along with Adrenal Cancer in 10 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The uptake and toxicity of cadmium were compared in two rat pheochromocytoma cell lines: PC12 cells, which express voltage-sensitive calcium channels, and PC18 cells, which do not." | 7.69 | Cadmium toxicity in rat pheochromocytoma cells: studies on the mechanism of uptake. ( Hinkle, PM; Osborne, ME, 1994) |
| "The uptake and toxicity of cadmium were compared in two rat pheochromocytoma cell lines: PC12 cells, which express voltage-sensitive calcium channels, and PC18 cells, which do not." | 3.69 | Cadmium toxicity in rat pheochromocytoma cells: studies on the mechanism of uptake. ( Hinkle, PM; Osborne, ME, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (60.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Albus, U | 1 |
| Habermann, E | 1 |
| Ferry, DR | 1 |
| Glossmann, H | 1 |
| Hinkle, PM | 1 |
| Osborne, ME | 1 |
| Schettini, G | 1 |
| Meucci, O | 1 |
| Grimaldi, M | 1 |
| Florio, T | 1 |
| Landolfi, E | 1 |
| Scorziello, A | 1 |
| Ventra, C | 1 |
| Chan, J | 1 |
| Greenberg, DA | 3 |
| Kolchinskaya, LI | 1 |
| Kononenko, NI | 1 |
| Pogorelaya, NC | 1 |
| Carpenter, CL | 2 |
| Cooper, EC | 1 |
| Harris, KM | 1 |
| Kongsamut, S | 1 |
| Miller, RJ | 1 |
| Schmid-Antomarchi, H | 1 |
| Hugues, M | 1 |
| Lazdunski, M | 1 |
| Oldham, SB | 1 |
| Ritchie, T | 1 |
| Noble, EP | 1 |
| Marks, SS | 1 |
| Watson, DL | 1 |
| Messing, RO | 1 |
1 review available for bay-k-8644 and Adrenal Cancer
| Article | Year |
|---|---|
Ethanol exposure alters K+- but not bradykinin-induced dopamine release in PC12 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1989 |
9 other studies available for bay-k-8644 and Adrenal Cancer
| Article | Year |
|---|---|
Novel 1,4-dihydropyridine (Bay K 8644) facilitates calcium-dependent [3H]noradrenaline release from PC 12 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1984 |
Cadmium toxicity in rat pheochromocytoma cells: studies on the mechanism of uptake.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Dihydropyridine modulation of voltage-activated calcium channels in PC12 cells: effect of pertussis toxin pretreatment.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Effects of glucose on calcium channels in neural cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Inhibition by oxytocin of voltage-activated calcium influx in cultured PC12 pheochromocytoma cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Stimulation of calcium uptake in PC12 cells by the dihydropyridine agonist BAY K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1985 |
Protein kinase C mediated regulation of calcium channels in PC-12 pheochromocytoma cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1986 |
Properties of the apamin-sensitive Ca2+-activated K+ channel in PC12 pheochromocytoma cells which hyper-produce the apamin receptor.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1986 |
Comparative effects of chronic exposure to ethanol and calcium channel antagonists on calcium channel antagonist receptors in cultured neural (PC12) cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1989 |