bay-k-8644 has been researched along with Ache in 8 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of the calcium channel antagonists diltiazem, nifedipine and verapamil and the calcium channel agonist, BAY K 8644, on offensive and defensive aggression and defeat-induced opioid analgesia were examined in male mice in resident-intruder interactions." | 3.67 | Aggression and defeat-induced opioid analgesia displayed by mice are modified by calcium channel antagonists and agonists. ( Kavaliers, M, 1987) |
| "7 nmol), the log dose-response relationship being shifted to left by pretreatment with 5 mg/kg i." | 1.29 | Calcium channel modulators modify K opioid-induced inhibition of C-fiber-evoked spinal reflexes in rat. ( Contreras, E; Hernández, A; Paeile, C; Pelissier, T; Pérez, H; Quijada, L; Soto-Moyano, R, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baraldi, PG | 1 |
| Preti, D | 1 |
| Materazzi, S | 1 |
| Geppetti, P | 1 |
| Lü, N | 1 |
| Cheng, LZ | 1 |
| Zhang, YQ | 1 |
| Lü, BC | 1 |
| Li, YQ | 1 |
| Zhao, ZQ | 1 |
| Hagiwara, K | 1 |
| Nakagawasai, O | 1 |
| Murata, A | 1 |
| Yamadera, F | 1 |
| Miyoshi, I | 1 |
| Tan-No, K | 1 |
| Tadano, T | 1 |
| Yanagisawa, T | 1 |
| Iijima, T | 1 |
| Murakami, M | 1 |
| Hernández, A | 1 |
| Contreras, E | 1 |
| Paeile, C | 1 |
| Pérez, H | 1 |
| Pelissier, T | 1 |
| Quijada, L | 1 |
| Soto-Moyano, R | 1 |
| Morisset, V | 1 |
| Nagy, F | 1 |
| Horváth, G | 1 |
| Brodacz, B | 1 |
| Holzer-Petsche, U | 1 |
| Kavaliers, M | 2 |
1 review available for bay-k-8644 and Ache
| Article | Year |
|---|---|
Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Asthma; Humans; Ion Channel Gating; Neurons; Pain; Pe | 2010 |
7 other studies available for bay-k-8644 and Ache
| Article | Year |
|---|---|
Involvement of ryanodine receptors in tetanic sciatic stimulation-induced long-term potentiation of spinal dorsal horn and persistent pain in rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2012 |
Analgesic action of loperamide, an opioid agonist, and its blocking action on voltage-dependent Ca2+ channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2003 |
Calcium channel modulators modify K opioid-induced inhibition of C-fiber-evoked spinal reflexes in rat.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1993 |
Ionic basis for plateau potentials in deep dorsal horn neurons of the rat spinal cord.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Role of calcium channels in the spinal transmission of nociceptive information from the mesentery.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2001 |
Aggression and defeat-induced opioid analgesia displayed by mice are modified by calcium channel antagonists and agonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Stimulatory influences of calcium channel antagonists on stress-induced opioid analgesia and locomotor activity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |