bay-k-8644 has been researched along with Absence Seizure in 21 studies
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A dextromethorphan (3-methoxy-17-methylmorphinan) analog, dimemorfan (3-methyl-N-methylmorphinan) that is not metabolized to dextrorphan [3-hydroxy-17-methylmorphinan, which induces phencyclidine (PCP)-like behavioral effects], attenuates maximal electroshock seizures." | 7.72 | Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice. ( Cha, JY; Jhoo, JH; Jhoo, WK; Kim, HC; Kim, WK; Ko, KH; Lee, PH; Nabeshima, T; Shin, EJ, 2004) |
| "c) potentiated seizures induced in rats by kainic acid (KA) (10 mg/kg, i." | 7.71 | Effects of dextromethorphan on the seizures induced by kainate and the calcium channel agonist BAY k-8644: comparison with the effects of dextrorphan. ( Jhoo, WK; Kang, KS; Kim, HC; Kim, WK; Ko, KH; Shin, CY; Shin, EJ, 2001) |
| "A dextromethorphan (3-methoxy-17-methylmorphinan) analog, dimemorfan (3-methyl-N-methylmorphinan) that is not metabolized to dextrorphan [3-hydroxy-17-methylmorphinan, which induces phencyclidine (PCP)-like behavioral effects], attenuates maximal electroshock seizures." | 3.72 | Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice. ( Cha, JY; Jhoo, JH; Jhoo, WK; Kim, HC; Kim, WK; Ko, KH; Lee, PH; Nabeshima, T; Shin, EJ, 2004) |
| "c) potentiated seizures induced in rats by kainic acid (KA) (10 mg/kg, i." | 3.71 | Effects of dextromethorphan on the seizures induced by kainate and the calcium channel agonist BAY k-8644: comparison with the effects of dextrorphan. ( Jhoo, WK; Kang, KS; Kim, HC; Kim, WK; Ko, KH; Shin, CY; Shin, EJ, 2001) |
| "We report the effects of two new dihydropyridine derivatives, isradipine (4-(4'-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedic arboxylic acid methylisopropylester) and niguldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride), and of dantrolene (1-[(5-[p-nitrophenyl]furfurylidene)-amino]hydantoin sodium, an inhibitor of Ca2+ release from intracellular stores) on the protective efficacy of antiepileptic drugs against maximal electroshock-induced seizures." | 3.69 | Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice. ( Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1997) |
| ") potentiated the anticonvulsant properties of phenytoin, phenobarbital and valproate against audiogenic seizures in DBA/2 mice." | 3.68 | Effects of some calcium antagonists upon the activity of common antiepileptic compounds on sound-induced seizures in DBA/2 mice. ( De Sarro, A; De Sarro, GB; Nistico', G; Trimarchi, GR, 1992) |
| "The effects of chemically and electrically-evoked seizures on [3H]nitrendipine binding to voltage-dependent calcium channels in mouse brain were determined 30 and 60 min following the initiation of convulsions." | 3.67 | The effects of chemically and electrically-induced convulsions on [3H]nitrendipine binding in mouse brain. ( Bolger, GT; Weissman, BA, 1987) |
| "These electrographic seizures and the ensuing hyperoxic episodes are associated with deficits in working memory and motor coordination that were reversible through attenuation of the posttraumatic and postictal (postseizure) hyperoxia, via administration of a vasoconstricting agent, the calcium channel agonist Bay K8644." | 1.72 | Electrographic seizures and brain hyperoxia may be key etiological factors for postconcussive deficits. ( Malik, H; Mychasiuk, R; Teskey, GC; Wolff, MD, 2022) |
| "In models of complex partial seizures like the hippocampal stimulation and the amygdala kindling in rats, flunarizine showed only a moderate activity." | 1.32 | Anticonvulsant profile of flunarizine and relation to Na(+) channel blocking effects. ( De Sarro, G; Fischer, W; Kittner, H; Regenthal, R, 2004) |
| "However, the latencies to convulsions were also increased." | 1.29 | Effects of diltiazem in convulsive states differ from those previously reported for dihydropyridine calcium channel antagonists. ( Little, HJ; Watson, WP, 1994) |
| "2." | 1.28 | Effects of antiepileptic drugs, calcium channel blockers and other compounds on seizures induced by activation of voltage-dependent L calcium channel in DBA/2 mice. ( Ascioti, C; De Sarro, A; De Sarro, G; di Paola, ED; Vidal, MJ, 1992) |
| " All the signs of hyperexcitability in field potentials in the isolated hippocampal slice, caused by ethanol withdrawal, were decreased by the chronic administration of Bay K 8644." | 1.28 | The effects of chronic treatment with the dihydropyridine, Bay K 8644, on hyperexcitability due to ethanol withdrawal, in vivo and in vitro. ( Butterworth, AR; Dolin, SJ; Little, HJ; Patch, TL; Whittington, MA, 1992) |
| "Nimodipine did not affect convulsions elicited by strychnine." | 1.28 | The effects of dihydropyridine calcium channel modulators on pentylenetetrazole convulsions. ( Bolger, GT; O'Neill, SK, 1990) |
| "Clonazepam did not produce anaesthesia, at doses up to 1 g kg-1 or when given with nitrendipine." | 1.28 | Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644. ( Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Taberner, PV, 1991) |
| " Chronic administration of CCI's, previously shown to produce down-regulation of the binding of the CCI [3H]nitrendipine, resulted in augmentation of BAY k 8644-induced seizures." | 1.27 | Induction of seizures in mice by intracerebroventricular administration of the calcium channel agonist BAY k 8644. ( Freed, WJ; Grebb, JA; Shelton, RC, 1987) |
| "In contrast, the severity of seizures produced by N-methyl-dl-aspartate (NMA) was increased by nitrendipine." | 1.27 | Anticonvulsant profile of the dihydropyridine calcium channel antagonists, nitrendipine and nimodipine. ( Dolin, SJ; Halsey, MJ; Hunter, AB; Little, HJ, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (14.29) | 18.7374 |
| 1990's | 12 (57.14) | 18.2507 |
| 2000's | 4 (19.05) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Malik, H | 1 |
| Wolff, MD | 1 |
| Teskey, GC | 1 |
| Mychasiuk, R | 1 |
| Tran, NKC | 1 |
| Jeong, JH | 1 |
| Sharma, N | 1 |
| Nguyen, YND | 1 |
| Tran, HP | 1 |
| Dang, DK | 1 |
| Park, JH | 1 |
| Byun, JK | 1 |
| Jin, D | 1 |
| Xiaoyan, Z | 1 |
| Ko, SK | 1 |
| Nah, SY | 1 |
| Kim, HC | 3 |
| Shin, EJ | 3 |
| Fischer, W | 1 |
| Kittner, H | 1 |
| Regenthal, R | 1 |
| De Sarro, G | 2 |
| Nabeshima, T | 1 |
| Lee, PH | 1 |
| Kim, WK | 2 |
| Ko, KH | 2 |
| Jhoo, JH | 1 |
| Jhoo, WK | 2 |
| Cha, JY | 1 |
| van Luijtelaar, EL | 1 |
| Ates, N | 1 |
| Coenen, AM | 1 |
| Czuczwar, SJ | 3 |
| Gasior, M | 2 |
| Turski, WA | 1 |
| Kleinrok, Z | 3 |
| Watson, WP | 1 |
| Little, HJ | 4 |
| Tusell, JM | 1 |
| Barron, S | 1 |
| Serratosa, J | 1 |
| Borowicz, KK | 2 |
| Campbell, DB | 1 |
| Hess, EJ | 1 |
| Kang, KS | 1 |
| Shin, CY | 1 |
| Zhao, P | 1 |
| Wan, XS | 1 |
| Xu, Q | 1 |
| Ascioti, C | 1 |
| di Paola, ED | 1 |
| Vidal, MJ | 1 |
| De Sarro, A | 2 |
| Whittington, MA | 1 |
| Butterworth, AR | 1 |
| Dolin, SJ | 3 |
| Patch, TL | 2 |
| De Sarro, GB | 1 |
| Trimarchi, GR | 1 |
| Nistico', G | 1 |
| O'Neill, SK | 1 |
| Bolger, GT | 2 |
| Rabbani, M | 1 |
| Taberner, PV | 1 |
| Shelton, RC | 1 |
| Grebb, JA | 1 |
| Freed, WJ | 1 |
| Weissman, BA | 1 |
| Hunter, AB | 1 |
| Halsey, MJ | 1 |
21 other studies available for bay-k-8644 and Absence Seizure
| Article | Year |
|---|---|
Electrographic seizures and brain hyperoxia may be key etiological factors for postconcussive deficits.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2022 |
Ginsenoside Re blocks Bay k-8644-induced neurotoxicity via attenuating mitochondrial dysfunction and PKCĪ“ activation in the hippocampus of mice: Involvement of antioxidant potential.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2023 |
Anticonvulsant profile of flunarizine and relation to Na(+) channel blocking effects.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2004 |
Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2004 |
Role of L-type calcium channel modulation in nonconvulsive epilepsy in rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Influence of a Ca2+ channel agonist, Bay k-8644, on the anticonvulsant activity of NMDA and non-NMDA receptor antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Effects of diltiazem in convulsive states differ from those previously reported for dihydropyridine calcium channel antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Anticonvulsant activity of calmodulin antagonist W-7 in convulsions induced by lindane and BayK-8644: effects in c-fos expression.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1994 |
Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
L-type calcium channels contribute to the tottering mouse dystonic episodes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Effects of dextromethorphan on the seizures induced by kainate and the calcium channel agonist BAY k-8644: comparison with the effects of dextrorphan.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2001 |
Behavior and activities in the central nervous system after activation of L-type calcium channels in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Niguldipine impairs the protective activity of carbamazepine and phenobarbital in amygdala-kindled seizures in rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |
Effects of antiepileptic drugs, calcium channel blockers and other compounds on seizures induced by activation of voltage-dependent L calcium channel in DBA/2 mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
The effects of chronic treatment with the dihydropyridine, Bay K 8644, on hyperexcitability due to ethanol withdrawal, in vivo and in vitro.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Effects of some calcium antagonists upon the activity of common antiepileptic compounds on sound-induced seizures in DBA/2 mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
The effects of dihydropyridine calcium channel modulators on pentylenetetrazole convulsions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Induction of seizures in mice by intracerebroventricular administration of the calcium channel agonist BAY k 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
The effects of chemically and electrically-induced convulsions on [3H]nitrendipine binding in mouse brain.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Anticonvulsant profile of the dihydropyridine calcium channel antagonists, nitrendipine and nimodipine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1988 |