bay h 4502 has been researched along with Nail Fungus in 24 studies
bifonazole : A racemate comprising equimolar amounts of R- and S-bifonazole. It is a broad spectrum antifungal drug used for the treatment of fungal skin and nail infections.
1-[biphenyl-4-yl(phenyl)methyl]imidazole : A member of the class of imidazoles carrying an alpha-(biphenyl-4-yl)benzyl substituent at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to verify efficacy and tolerability of sequential therapy with 40% urea paste followed by 1% bifonazole urea in mild to moderate distal subungual onychomycosis of the toenails." | 9.22 | Evaluation of efficacy and tolerability of four weeks bifonazole treatment after nail ablation with 40% urea in mild to moderate distal subungual onychomycosis. ( Alessandrini, A; Bruni, F; Piraccini, BM; Starace, M, 2016) |
| "A parallel-group double-blind study was carried out which compared the efficacy of chemical avulsion of affected nail by urea 40% and bifonazole 1% cream alone with that of the same local therapy combined with short-term oral griseofulvin in onychomycosis." | 9.08 | Treatment of onychomycosis: a randomized, double-blind comparison study with topical bifonazole-urea ointment alone and in combination with short-duration oral griseofulvin. ( Bergman, R; Bitterman, O; Cohen, A; Friedman-Birnbaum, R; Shemer, A; Stettendorf, S, 1997) |
| "The rate of success in treating onychomycosis with 40% urea ointment containing 1% bifonazole, with and without oral griseofulvin, was evaluated." | 9.07 | [Treatment of onychomycosis using 40% urea with 1% bifonazole]. ( Bergman, R; Cohen, A; Friedman-Birnbaum, R; Shemer, A, 1992) |
| "We report a case of proximal fold cellulitis in both big toes, associated with a bilateral proximal onychomycosis and an intertrigo of the fourth space due to Fusarium solani." | 7.73 | [Bilateral proximal cellulitis and onychomycosis in both big toes due to Fusarium solani]. ( Sellart-Altisent, M; Torres-Rodríguez, JM, 2006) |
| "In the present study, we investigated the effects of bifonazole/urea ointment, a novel topical drug for the treatment of onychomycosis, on the ultrastructure of normal and fungus-infected human toenails by scanning electron microscopy." | 7.68 | Ultrastructural changes in onychomycosis during the treatment with bifonazole/urea ointment. ( Fritsch, H; Hegemann, L; Stettendorf, S, 1992) |
| "A clinical trial has been conducted to assess the efficacy of 1% bifonazole and 40% urea ointment for 2 weeks followed by 1% bifonazole cream for one month in the topical treatment of onychomycosis." | 7.68 | Treatment of onychomycosis with a bifonazole-urea combination. ( Hardjoko, FS; Singgih, I; Susilo, J; Widyanto, S, 1990) |
| " The number of patients with at least one adverse event was twice as high in the bifonazole-urea group in comparison to the 40% urea ointment with plastic dressing group." | 6.78 | Efficacy, safety and tolerability of an optimized avulsion technique with onyster® (40% urea ointment with plastic dressing) ointment compared to bifonazole-urea ointment for removal of the clinically infected nail in toenail onychomycosis: a randomized e ( Baran, R; Bulai-Livideanu, C; Coubetergues, H; Lahfa, M; Ortonne, JP; Paul, C; Piraccini, BM; Richert, B; Sibaud, V; Szepietowski, JC; Tosti, A; Voisard, JJ, 2013) |
| "Onychomycosis is a common fungal infection most often affecting the toenails." | 6.78 | Efficacy of 4 weeks topical bifonazole treatment for onychomycosis after nail ablation with 40% urea: a double-blind, randomized, placebo-controlled multicenter study. ( Delcker, A; Hay, R; Kurka, P; Merk, HF; Querner, S; Tietz, HJ, 2013) |
| "These results suggest that the topical treatment of onychomycosis by occlusive dressing is a useful method for those patients who have difficulties in or do not wish to be treated with oral antifungal agents." | 6.69 | [Topical treatment of onychomycosis by occlusive dressing using bifonazole cream containing 40% urea]. ( Higashi, N; Kasai, T; Kitamura, K; Komatsuzaki, H; Nakashima, Y; Nishimoto, K; Ogawa, H; Oka, K; Takiuchi, I; Tsuboi, R; Unno, K, 1998) |
| "The aim of this study was to verify efficacy and tolerability of sequential therapy with 40% urea paste followed by 1% bifonazole urea in mild to moderate distal subungual onychomycosis of the toenails." | 5.22 | Evaluation of efficacy and tolerability of four weeks bifonazole treatment after nail ablation with 40% urea in mild to moderate distal subungual onychomycosis. ( Alessandrini, A; Bruni, F; Piraccini, BM; Starace, M, 2016) |
| "A parallel-group double-blind study was carried out which compared the efficacy of chemical avulsion of affected nail by urea 40% and bifonazole 1% cream alone with that of the same local therapy combined with short-term oral griseofulvin in onychomycosis." | 5.08 | Treatment of onychomycosis: a randomized, double-blind comparison study with topical bifonazole-urea ointment alone and in combination with short-duration oral griseofulvin. ( Bergman, R; Bitterman, O; Cohen, A; Friedman-Birnbaum, R; Shemer, A; Stettendorf, S, 1997) |
| "The rate of success in treating onychomycosis with 40% urea ointment containing 1% bifonazole, with and without oral griseofulvin, was evaluated." | 5.07 | [Treatment of onychomycosis using 40% urea with 1% bifonazole]. ( Bergman, R; Cohen, A; Friedman-Birnbaum, R; Shemer, A, 1992) |
| "We report a case of proximal fold cellulitis in both big toes, associated with a bilateral proximal onychomycosis and an intertrigo of the fourth space due to Fusarium solani." | 3.73 | [Bilateral proximal cellulitis and onychomycosis in both big toes due to Fusarium solani]. ( Sellart-Altisent, M; Torres-Rodríguez, JM, 2006) |
| "A new formulation was used as a nail lacquer containing 40% urea in a film-forming solution in 10 patients presenting with onychomycosis." | 3.71 | Chemical avulsion with urea nail lacquer. ( Baran, R; Tosti, A, 2002) |
| "In the present study, we investigated the effects of bifonazole/urea ointment, a novel topical drug for the treatment of onychomycosis, on the ultrastructure of normal and fungus-infected human toenails by scanning electron microscopy." | 3.68 | Ultrastructural changes in onychomycosis during the treatment with bifonazole/urea ointment. ( Fritsch, H; Hegemann, L; Stettendorf, S, 1992) |
| "A clinical trial has been conducted to assess the efficacy of 1% bifonazole and 40% urea ointment for 2 weeks followed by 1% bifonazole cream for one month in the topical treatment of onychomycosis." | 3.68 | Treatment of onychomycosis with a bifonazole-urea combination. ( Hardjoko, FS; Singgih, I; Susilo, J; Widyanto, S, 1990) |
| " In our investigations into the treatment of onychomycosis we studied the use of bifonazole (1%)-urea ointment and the therapeutic possibilities in connection with its application." | 3.67 | Non-traumatic removal of the nail and simultaneous treatment of onychomycosis. ( Nolting, S, 1984) |
| " Study B: More subjects adhered to amorolfine dosage (81." | 2.84 | Patient-reported outcomes from two randomised studies comparing once-weekly application of amorolfine 5% nail lacquer to other methods of topical treatment in distal and lateral subungual onychomycosis. ( Sarkany, M; Schaller, M; Sigurgeirsson, B, 2017) |
| " The number of patients with at least one adverse event was twice as high in the bifonazole-urea group in comparison to the 40% urea ointment with plastic dressing group." | 2.78 | Efficacy, safety and tolerability of an optimized avulsion technique with onyster® (40% urea ointment with plastic dressing) ointment compared to bifonazole-urea ointment for removal of the clinically infected nail in toenail onychomycosis: a randomized e ( Baran, R; Bulai-Livideanu, C; Coubetergues, H; Lahfa, M; Ortonne, JP; Paul, C; Piraccini, BM; Richert, B; Sibaud, V; Szepietowski, JC; Tosti, A; Voisard, JJ, 2013) |
| "Onychomycosis is a common fungal infection most often affecting the toenails." | 2.78 | Efficacy of 4 weeks topical bifonazole treatment for onychomycosis after nail ablation with 40% urea: a double-blind, randomized, placebo-controlled multicenter study. ( Delcker, A; Hay, R; Kurka, P; Merk, HF; Querner, S; Tietz, HJ, 2013) |
| "These results suggest that the topical treatment of onychomycosis by occlusive dressing is a useful method for those patients who have difficulties in or do not wish to be treated with oral antifungal agents." | 2.69 | [Topical treatment of onychomycosis by occlusive dressing using bifonazole cream containing 40% urea]. ( Higashi, N; Kasai, T; Kitamura, K; Komatsuzaki, H; Nakashima, Y; Nishimoto, K; Ogawa, H; Oka, K; Takiuchi, I; Tsuboi, R; Unno, K, 1998) |
| "Onychomycosis is a rare nail disorder in early childhood, while onychomadesis is a periodic idiopathic, non-inflammatory disease that affects the nail matrix and is common in children especially in those who suffer from viral infections." | 1.46 | Onychomycosis secondary to onychomadesis: an underdiagnosed manifestation. ( Chen, Z; De Hoog, GS; Feng, P; Huang, H; Lai, W; Li, M; Lu, C; Wei, L; Xue, R; Yin, S, 2017) |
| "The successful treatment of onychomycosis requires special knowledge of the various clinical presentations, of the differential diagnosis and of recent advances in medical mycology." | 1.32 | [Onychomycosis]. ( Reinel, D, 2004) |
| "Therapy for onychomycosis is difficult because a complete cure requires long-term treatment." | 1.31 | Experimental tinea unguium model to assess topical antifungal agents using the infected human nail with dermatophyte in vitro. ( Ito, T; Majima, T; Nakashima, T; Nozawa, A, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.67) | 18.7374 |
| 1990's | 6 (25.00) | 18.2507 |
| 2000's | 6 (25.00) | 29.6817 |
| 2010's | 8 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schaller, M | 2 |
| Sigurgeirsson, B | 1 |
| Sarkany, M | 1 |
| Lahfa, M | 1 |
| Bulai-Livideanu, C | 1 |
| Baran, R | 2 |
| Ortonne, JP | 1 |
| Richert, B | 1 |
| Tosti, A | 2 |
| Piraccini, BM | 2 |
| Szepietowski, JC | 1 |
| Sibaud, V | 1 |
| Coubetergues, H | 1 |
| Voisard, JJ | 1 |
| Paul, C | 1 |
| Tietz, HJ | 1 |
| Hay, R | 1 |
| Querner, S | 1 |
| Delcker, A | 1 |
| Kurka, P | 1 |
| Merk, HF | 1 |
| Aspiroz, C | 1 |
| Fortuño-Cebamanos, B | 1 |
| Rezusta, A | 1 |
| Gilaberte, Y | 1 |
| Bruni, F | 1 |
| Alessandrini, A | 1 |
| Starace, M | 1 |
| Li, M | 1 |
| Chen, Z | 2 |
| Yin, S | 1 |
| Xue, R | 1 |
| Huang, H | 1 |
| Wei, L | 1 |
| Lu, C | 1 |
| De Hoog, GS | 1 |
| Lai, W | 1 |
| Feng, P | 1 |
| Eichenfield, LF | 1 |
| Friedlander, SF | 1 |
| Carrillo-Muñoz, AJ | 1 |
| Quindós, G | 1 |
| Del Valle, O | 1 |
| Santos, P | 1 |
| Giusiano, G | 1 |
| Guardia, C | 1 |
| Eraso, E | 1 |
| Ezkurra, PA | 1 |
| Tur-Tur, C | 1 |
| Hernández-Molina, JM | 1 |
| Borelli, C | 1 |
| Berger, U | 1 |
| Walker, B | 1 |
| Schmidt, S | 1 |
| Weindl, G | 1 |
| Jäckel, A | 1 |
| Arabatzis, M | 1 |
| Nakashima, T | 1 |
| Nozawa, A | 1 |
| Ito, T | 1 |
| Majima, T | 1 |
| Reinel, D | 1 |
| Torres-Rodríguez, JM | 1 |
| Sellart-Altisent, M | 1 |
| Nolting, S | 2 |
| Bonifaz, A | 1 |
| Guzmán, A | 1 |
| Garcia, C | 1 |
| Sosa, J | 1 |
| Saúl, A | 1 |
| Friedman-Birnbaum, R | 2 |
| Cohen, A | 2 |
| Shemer, A | 2 |
| Bitterman, O | 1 |
| Bergman, R | 2 |
| Stettendorf, S | 2 |
| Tsuboi, R | 1 |
| Unno, K | 1 |
| Komatsuzaki, H | 1 |
| Ogawa, H | 1 |
| Kasai, T | 1 |
| Oka, K | 1 |
| Takiuchi, I | 1 |
| Kitamura, K | 1 |
| Higashi, N | 1 |
| Nakashima, Y | 1 |
| Nishimoto, K | 1 |
| Fritsch, H | 1 |
| Hegemann, L | 1 |
| Hardjoko, FS | 1 |
| Widyanto, S | 1 |
| Singgih, I | 1 |
| Susilo, J | 1 |
| Roberts, DT | 2 |
| Hay, RJ | 2 |
| Doherty, VR | 2 |
| Richardson, MD | 2 |
| Clayton, YM | 1 |
| Midgley, G | 1 |
1 review available for bay h 4502 and Nail Fungus
| Article | Year |
|---|---|
Pediatric Onychomycosis: The Emerging Role of Topical Therapy.
Topics: Administration, Topical; Adult; Age Factors; Antifungal Agents; Child; Ciclopirox; Family; Humans; I | 2017 |
9 trials available for bay h 4502 and Nail Fungus
| Article | Year |
|---|---|
Patient-reported outcomes from two randomised studies comparing once-weekly application of amorolfine 5% nail lacquer to other methods of topical treatment in distal and lateral subungual onychomycosis.
Topics: Administration, Topical; Adult; Aged; Antifungal Agents; Ciclopirox; Drug Administration Schedule; F | 2017 |
Efficacy, safety and tolerability of an optimized avulsion technique with onyster® (40% urea ointment with plastic dressing) ointment compared to bifonazole-urea ointment for removal of the clinically infected nail in toenail onychomycosis: a randomized e
Topics: Administration, Topical; Adult; Aged; Antifungal Agents; Female; Foot Dermatoses; Humans; Imidazoles | 2013 |
Efficacy of 4 weeks topical bifonazole treatment for onychomycosis after nail ablation with 40% urea: a double-blind, randomized, placebo-controlled multicenter study.
Topics: Ablation Techniques; Administration, Topical; Adult; Aged; Aged, 80 and over; Antifungal Agents; Dou | 2013 |
Evaluation of efficacy and tolerability of four weeks bifonazole treatment after nail ablation with 40% urea in mild to moderate distal subungual onychomycosis.
Topics: Adult; Aged; Antifungal Agents; Drug Administration Schedule; Drug Therapy, Combination; Female; Hum | 2016 |
Efficacy and safety of bifonazole urea in the two-phase treatment of onychomycosis.
Topics: Administration, Topical; Adolescent; Adult; Aged; Antifungal Agents; Child; Child, Preschool; Combin | 1995 |
Treatment of onychomycosis: a randomized, double-blind comparison study with topical bifonazole-urea ointment alone and in combination with short-duration oral griseofulvin.
Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Aged; Antifungal Agents; Double-Bl | 1997 |
[Topical treatment of onychomycosis by occlusive dressing using bifonazole cream containing 40% urea].
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antifungal Agents; Candidiasis; Female; Hum | 1998 |
[Treatment of onychomycosis using 40% urea with 1% bifonazole].
Topics: Administration, Oral; Adult; Antifungal Agents; Drug Therapy, Combination; Female; Griseofulvin; Hum | 1992 |
The topical treatment of onychomycosis using a new combined urea/imidazole preparation.
Topics: Administration, Topical; Adult; Aged; Antifungal Agents; Clinical Trials as Topic; Drug Combinations | 1988 |
14 other studies available for bay h 4502 and Nail Fungus
| Article | Year |
|---|---|
Photodynamic therapy with methyl-aminolevulinate can be useful in the management of Scytalidium infections.
Topics: Aminolevulinic Acid; Antifungal Agents; Aspergillosis; Coinfection; Combined Modality Therapy; Femal | 2013 |
Onychomycosis secondary to onychomadesis: an underdiagnosed manifestation.
Topics: Administration, Topical; Antifungal Agents; Candida; Candida glabrata; Candida tropicalis; Child; Ch | 2017 |
In vitro antifungal activity of sertaconazole nitrate against recent isolates of onychomycosis causative agents.
Topics: Antifungal Agents; Arthrodermataceae; Ciclopirox; Dose-Response Relationship, Drug; Fluconazole; Fun | 2008 |
Chemical avulsion with urea nail lacquer.
Topics: Administration, Cutaneous; Adult; Aged; Antifungal Agents; Cohort Studies; Female; Foot Dermatoses; | 2002 |
Susceptibility testing of amorolfine, bifonazole and ciclopiroxolamine against Trichophyton rubrum in an in vitro model of dermatophyte nail infection.
Topics: Administration, Topical; Antifungal Agents; Ciclopirox; Humans; Imidazoles; Microbial Sensitivity Te | 2009 |
Hypothyroidism-related onycholysis with Aureobasidium pullulans colonization successfully treated with antifungal therapy.
Topics: Adult; Antifungal Agents; Ascomycota; Female; Hand Dermatoses; Humans; Hypothyroidism; Imidazoles; I | 2012 |
Experimental tinea unguium model to assess topical antifungal agents using the infected human nail with dermatophyte in vitro.
Topics: Adult; Antifungal Agents; Female; Humans; Imidazoles; Male; Middle Aged; Morpholines; Nails; Naphtha | 2002 |
[Onychomycosis].
Topics: Antifungal Agents; Ciclopirox; Debridement; Diagnosis, Differential; Drug Therapy, Combination; Fluc | 2004 |
[Bilateral proximal cellulitis and onychomycosis in both big toes due to Fusarium solani].
Topics: Antifungal Agents; Cellulitis; Ciclopirox; Diabetes Mellitus, Type 2; Disease Susceptibility; Drug R | 2006 |
Non-traumatic removal of the nail and simultaneous treatment of onychomycosis.
Topics: Antifungal Agents; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Imidazoles; Male; N | 1984 |
Ultrastructural changes in onychomycosis during the treatment with bifonazole/urea ointment.
Topics: Administration, Topical; Antifungal Agents; Drug Combinations; Foot Dermatoses; Humans; Imidazoles; | 1992 |
Treatment of onychomycosis with a bifonazole-urea combination.
Topics: Administration, Topical; Adolescent; Adult; Antifungal Agents; Child; Drug Therapy, Combination; Fem | 1990 |
[Onychomycoses and their successful therapy].
Topics: Administration, Topical; Antifungal Agents; Drug Therapy, Combination; Foot Dermatoses; Hand Dermato | 1989 |
Topical treatment of onychomycosis using bifonazole 1% urea/40% paste.
Topics: Administration, Topical; Antifungal Agents; Humans; Imidazoles; Ointments; Onychomycosis; Urea | 1988 |