bay-44-4400 and Trichuriasis

Current treatments for soil-transmitted helminth infections in humans have low efficacy against. We conducted two phase 2a, dose-ranging, randomized, controlled trials to evaluate the efficacy and safety of emodepside against. A total of 266 persons were enrolled in the. Emodepside showed activity against

Topics: Administration, Oral; Adult; Albendazole; Animals; Antinematodal Agents; Depsipeptides; Dose-Response Relationship, Drug; Feces; Hookworm Infections; Humans; Middle Aged; Soil; Trichuriasis; Trichuris; Young Adult

The efficacy of emodepside plus toltrazuril oral suspension for dogs (Procox®, Bayer) against Trichuris vulpis was evaluated in a controlled, blinded and randomised laboratory study. Twenty naturally infected dogs were included. Dogs in the treatment group received the minimum therapeutic dose of 0.45 mg emodepside and 9 mg toltrazuril per kg body weight, while dogs in the control group were left untreated. Efficacy was calculated based on worm counts after necropsy on Day 7 post treatment. Additionally, all faeces were collected and examined for expelled worms. The treatment was 100 % effective. A total of 233 adult worms (geometric mean 17.0) and 3 immature adult worms were found in the control group at necropsy. Adequacy of infection was demonstrated. The treated group excreted a total of 186 adult worms within 2 days after treatment. Additionally, all dogs were co-infected with Uncinaria stenocephala. Efficacy against this parasite was 99.8 %. No side effects of the treatment were observed. This study demonstrates that in addition to the formerly proven efficacy against Toxocara canis, Ancylostoma caninum and Uncinaria stenocephala, emodepside plus toltrazuril suspension is also effective against T. vulpis and thus represents a convenient treatment option for dogs co-infected with whipworms and coccidia.

Topics: Administration, Oral; Ancylostomatoidea; Animals; Anthelmintics; Coinfection; Depsipeptides; Dogs; Double-Blind Method; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Feces; Parasite Load; Suspensions; Treatment Outcome; Triazines; Trichuriasis; Trichuris

This paper reports on the efficacy of a novel flavoured tablet formulation of emodepside plus praziquantel (Profender tablets for dogs) against mature and immature adult whipworms (Trichuris vulpis) at the proposed minimum dose of 1 mg emodepside and 5 mg praziquantel per kg body weight in dogs. Three randomised, blinded and controlled laboratory studies with naturally or experimentally infected dogs were performed. The first study was conducted as a dose determination study in experimentally infected dogs using three different dose levels, i.e., 0.5x, 1x and 2x the minimum therapeutic dose. Two further studies confirmed the efficacy of emodepside plus praziquantel tablets against mature and immature adult T. vulpis at the recommended minimum dose. In all three studies, the efficacy against mature and immature adult T. vulpis was >99%. No side effects of the treatment were observed. It is concluded that the emodepside plus praziquantel tablet is an effective and safe treatment against mature and immature adult stages of T. vulpis in dogs.

Topics: Administration, Oral; Animals; Anthelmintics; Depsipeptides; Dog Diseases; Dogs; Double-Blind Method; Feces; Parasite Egg Count; Placebos; Praziquantel; Tablets; Treatment Outcome; Trichuriasis; Trichuris