bay-41-8543 has been researched along with Cardiomegaly* in 1 studies
1 other study(ies) available for bay-41-8543 and Cardiomegaly
| Article | Year |
|---|---|
Acute stimulation of the soluble guanylate cyclase does not impact on left ventricular capacitance in normal and hypertrophied porcine hearts in vivo.
Experimental data indicate that stimulation of the nitric oxide-soluble guanylate cyclase(sGC)-cGMP-PKG pathway can increase left ventricular (LV) capacitance via phosphorylation of the myofilamental protein titin. We aimed to test whether acute pharmacological sGC stimulation with BAY 41-8543 would increase LV capacitance via titin phosphorylation in healthy and deoxycorticosteroneacetate (DOCA)-induced hypertensive pigs. Nine healthy Landrace pigs and 7 pigs with DOCA-induced hypertension and LV concentric hypertrophy were acutely instrumented to measure LV end-diastolic pressure-volume relationships (EDPVRs) at baseline and during intravenous infusion of BAY 41-8543 (1 and 3 μg·kg Topics: Animals; Blood Pressure; Cardiomegaly; Connectin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Desoxycorticosterone Acetate; Female; Heart Ventricles; Morpholines; Nitroglycerin; Pyrimidines; Soluble Guanylyl Cyclase; Swine; Vascular Capacitance; Vasodilator Agents; Ventricular Function, Left | 2018 |