bay-11-7082 and Abdominal-Neoplasms

bay-11-7082 has been researched along with Abdominal-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for bay-11-7082 and Abdominal-Neoplasms

Article	Year
Nuclear factor kappaB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis. Cancer research, 2002, Dec-01, Volume: 62, Issue:23 The transcription factor nuclear factor kappaB (NFkappaB) is constitutively active in many types of cancercells and regulates the expression of several antiapoptotic genes. Previous studies demonstrated a role for the inhibition of NFkappaB in cancer therapyusing a transgenic approach in mice. We found that NFkappaB was transiently activated much greater than background constitutive levels during colon cancer cell readhesion, which rendered the readhering colon cancer cells exquisitely susceptible to apoptosis in the presence of soluble NFkappaB inhibitors. These compounds greatly reduced colon cancer cell implantation in an in vivo seeding model of metastasis. The ability of soluble NFkappaB inhibitors to significantly induce apoptosis of readherent colon cancer cells makes them prospective candidates for preventing colon cancer metastasis. Topics: Abdominal Neoplasms; Animals; Anti-Infective Agents; Antineoplastic Agents; Apoptosis; Cell Adhesion; Colonic Neoplasms; Female; Humans; Mice; Mice, Nude; Neoplasm Seeding; Neoplasm Transplantation; NF-kappa B; Nitriles; Organic Chemicals; Sulfones; Transplantation, Heterologous; Tumor Cells, Cultured	2002

Article

Year

Nuclear factor kappaB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis.

Cancer research, 2002, Dec-01, Volume: 62, Issue:23

The transcription factor nuclear factor kappaB (NFkappaB) is constitutively active in many types of cancercells and regulates the expression of several antiapoptotic genes. Previous studies demonstrated a role for the inhibition of NFkappaB in cancer therapyusing a transgenic approach in mice. We found that NFkappaB was transiently activated much greater than background constitutive levels during colon cancer cell readhesion, which rendered the readhering colon cancer cells exquisitely susceptible to apoptosis in the presence of soluble NFkappaB inhibitors. These compounds greatly reduced colon cancer cell implantation in an in vivo seeding model of metastasis. The ability of soluble NFkappaB inhibitors to significantly induce apoptosis of readherent colon cancer cells makes them prospective candidates for preventing colon cancer metastasis.

Topics: Abdominal Neoplasms; Animals; Anti-Infective Agents; Antineoplastic Agents; Apoptosis; Cell Adhesion; Colonic Neoplasms; Female; Humans; Mice; Mice, Nude; Neoplasm Seeding; Neoplasm Transplantation; NF-kappa B; Nitriles; Organic Chemicals; Sulfones; Transplantation, Heterologous; Tumor Cells, Cultured

2002